MLB Home Run Picks Today: Best HR Predictions for April 16th, 2026
Yesterday afternoon and last night saw some of the midweek series wrap up, and while that means a lighter day on the diamond today, we’ve got featured matchups on ESPN and MLB Network, not to mention the majority of the slate teeing off in the afternoon! Let’s make that even more exciting with our best MLB home run picks for today!
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⚾ Top MLB Home Run Picks for Today
One of the most exciting things across all sports, not just baseball, is seeing a hitter absolutely smack the laces off a ball. Whether it’s a walk-off homer, lead-off shot, or otherwise, who doesn’t want the top MLB home run picks?
They’re an awesome way for some big payouts with your MLB expert picks, and while we’re going to break down some prime spots for today, we know some fans just want our targets. So, here’s the quick hit of our best MLB home run predictions today:
- Rafael Devers: +324 at Novig Sportsbook
- William Contreras: +600 at DraftKings Sportsbook
- Mickey Moniak: +450 at DraftKings Sportsbook
🔥 Best Matchups for Home Runs Today, 4/16: Ballpark Factors & Weather Impact
So, why are we targeting those guys? As with anything, there are all kinds of variables to consider, from starting pitchers, bullpens, and what often flies under the radar, which is having the latest
MLB weather report. Along with overall ballpark factors, let’s break down our best MLB home run picks for today!
Rafael Devers (+324)
Leading things off is Rafael Devers in the early Giants vs. Reds matchup. He may not be the leadoff man, but this can still cash in the first inning with Willy Adames and Luis Arraez both having great ability to get on base. This is also the first of our best MLB home run picks today, with the game being in Cincinnati.
Despite Coors Field in Colorado being the best for runs overall, it’s actually the Great American Ball Park that ranks #1 for pure home runs. Devers will also be facing Chase Burns for the Reds, who has allowed two homers to lefties this early into the season. Consider Adames as well, but grab Rafael Devers home run (+324 at Novig) for our top MLB home run picks.
William Contreras (+600)
We’re going to go from one hitter-friendly ballpark to another one in Milwaukee. The Brewers finally snapped their six-game skid last night, and whether they start a win streak or not, we’ve got at least a homer coming from Contreras. After all, when Patrick Corbin is on the mound, we love making MLB home run picks!
The lefty was a favorite target for us as a Washington National, and that continues as a Toronto Blue Jay. Interestingly enough, Contreras homered against the Nats in Milwaukee’s last series, and so far in this one, he’s had two hits in both games. He’s had a hit in all 10 games this month (14 in total), so with how he’s seeing the ball right now, we’re adding to our best MLB home run picks today with a William Contreras home run (+600 at DraftKings).
Mickey Moniak (+450)
We mentioned Coors Field, so why not get the Colorado Rockies in here? Ok, they’re not at home tonight, but they do get to face Houston’s Ryan Weiss. In other words, this is a bullpen game for the Astros, who haven’t been great overall. Even without that factor, this would be part of our MLB home run picks.
Houston’s struggles have largely been due to their bullpen ERA being the second-worst in baseball thus far. Before the game even gets that far, Weiss has allowed a home run in each of his last two outings, and keep in mind, he’s pitching hardly two innings! So, let’s keep adding to our top MLB home run picks today with a Mickey Moniak home run (+450 at DraftKings).
🚀 Longshot Home Run Picks Today
In fact, let’s take things a step further. Getting some sweet plus-money on the guys above is awesome, but let’s add to them with our best MLB home run longshot pick for today.
The Orioles vs. Guardians series is the only new one starting today, and there could be some serious fireworks with how these teams have been hitting overs. We saw Jeremiah Jackson go yard for the O’s yesterday, so let’s get another Baltimore guy into our MLB home run picks with Taylor Ward.
💲 Today’s Best MLB Home Run Parlay
- Devers, Contreras, Moniak: +15069 at DraftKings, so a $10 bet pays $1,516.90!
Of course, you’re already getting some juicy payouts just taking these guys individually, but if you want even more skin in the game with a fun play, why not? No matter how you end up taking advantage of our top MLB home run predictions for today, grab some sign-up bonuses along the way using the links that you’ve seen above!
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