Technically, the MLB season tees off tonight with the standalone matchup on Netflix last night, but tomorrow, it’s time for the first actual slate of the 2026 season! It’s headlined by another primetime game on NBC/Peacock. It’s also a divisional rivalry that we get to enjoy, so we’re here to add to it with our best Diamondbacks vs. Dodgers predictions for MLB Opening Day.

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🔥 Diamondbacks vs. Dodgers Predictions for MLB Opening Day

Despite these two teams being the representatives for the NL in each of the past three World Series, it’s safe to say that things are looking far more optimistic in LA than in Arizona. Quite a bit has changed since the DBacks lost the Fall Classic, including the Dodgers winning each of the past two.

Of course, that will have plenty of Diamondbacks vs. Dodgers predictions simply picking LA to start out 1-0, but we need more than just that! We’re going to see the back-to-back defending champs start the season without Blake Snell, but they would have had Yoshinobu Yamamoto starting on MLB Opening Day, anyway.

Arizona is countering with Zach Gallen, given the Merrill Kelly injury, so at least there are no concerns in terms of wondering until the last minute who will be toeing the rubber. As for when these NFC West foes met last season, it was actually much more even than many fans would guess - LA narrowly won the season series with a 7-6 record.

From a betting perspective, however, Arizona was actually 9-4 in terms of covering the run line! Speaking of trends, we also saw games between these two teams go 8-3-2 in favor of the under. With the standard markets out of the way, let’s see where we want to put the focus of our Diamondbacks vs. Dodgers predictions to lock in some MLB expert picks.

🏅 Diamondbacks vs. Dodgers Best Bet: Yamamoto Over 5.5 K’s (Use Kalshi To Make Picks On Anything)

The Dodgers made some splashes this offseason - shocking! This time, the big acquisitions were Kyle Tucker and Edwin Diaz, and while they re-signed Enrique Hernandez, he’s going to be starting the season on the IL. Despite the name drops, our Diamondbacks vs. Dodgers predictions are still focused on a guy we came to love trusting last season.

Many times, it was with an outs prop, but we’re going to stick with K’s this time around. That may surprise some fans who remember the Arizona lineup last season. We say that because that was not where they struggled most, thanks to not striking out a ton. However, Yamamoto is one guy who was able to crack the code.

He was the starter for four different Diamondbacks vs. Dodgers predictions last season, and in each of the most recent three, he hit over this line by throwing 7, 9, and 10 K’s. There’s no doubt that Nolan Arenado will help boost this DBacks lineup, but that’s still just one hitter - Corbin Carroll struck out far too much last year.

Arizona can certainly make this a competitive game, but we’re still on Yoshinobu Yamamoto over 5.5 strikeouts (submit a trade with Kalshi prediction market) as the best bet from our Diamondbacks vs. Dodgers predictions.
 

 

 

👀 How To Watch Diamondbacks vs. Dodgers MLB Opening Day

The first iteration of this NL West clash this season is at the home of the back-to-back defending champs and the featured matchup of the slate, so here’s how to watch Diamondbacks vs. Dodgers MLB Opening Day:

  • Where: Dodger Stadium in Los Angeles, CA
  • When: 8:30 PM ET on 3/26
  • Watch on TV: NBC
  • Where to stream: Peacock

🔢 Diamondbacks vs. Dodgers Odds, Spreads, Total & Betting Lines

As you’d expect with the World Series favorites at their home stadium, LA is the clear favorite according to the latest Diamondbacks vs. Dodgers odds for MLB Opening Day:

 

 

⚾ Diamondbacks vs. Dodgers Injury Report & Starting Pitchers

We mentioned the key Diamondbacks vs. Dodgers injury in LA already - Enrique Hernandez - so let’s finish off their side of things. You’ll see more on their report, but as for noteworthy players, the other would be Tommy Edman.

Regarding Diamondbacks vs. Dodgers injuries in Arizona, we also already noted Merrill Kelly, and other key names would be Lourdes Gurriel, Jr., and Corbin Burnes. Monitor it all with our Fantasy Alarm MLB injury report, and speaking of pitchers, here are the Diamondbacks vs. Dodgers starters for MLB Opening Day:

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