CFB DFS Picks, Projections, Lineups & Stacks For 11/22: Week 13 Playbook

The 2025 college football season rolls on this Saturday, November 22nd, with a full Week 13 slate of games. Let’s dive into the top CFB DFS Picks as you build lineups on DraftKings and FanDuel. In this article, we’ll discuss the best plays at each position with CFB DFS projections factored in. 

As you read over our Week 13 CFB DFS Picks, take advantage of Fantasy Alarm’s College Football DFS Ownership Projections for both DK and FD. Plus, you can use our Weekly Player Projections and CFB DFS Lineup Generator. 

CFB DFS Picks, Daily Fantasy Playbook & Schedule: Saturday, November 22nd

Before we discuss top CFB DFS picks this week, let’s take a look at the slate. DraftKings has a 12-game main afternoon slate on Saturday. Meanwhile, FanDuel has a 14-game slate that includes 4 night games and 2 different afternoon matchups. For the write-ups, we’ll focus on top players and value CFB picks for games on both slates. However, check out our specific DraftKings and FanDuel core plays below. Here’s a look at the Week 13 CFB DFS schedule with betting lines and odds: 

DraftKings Main Slate: 

• 12 pm ET – Missouri at Oklahoma (-6.5) – 42.5 O/U
• 12 pm ET – Louisville at SMU (-3) – 51.5 O/U
• 12 pm ET – Miami FL (-18.5) at Virginia Tech – 49.5 O/U
• 12 pm ET – Rutgers at Ohio State (-32.5) – 55.5 O/U
• 1 pm ET – Baylor at Arizona (-7) – 62.5 O/U
• 3 pm ET – UConn (-7) at FAU – 64.5 O/U (DK Only)
• 3:30 pm ET – Arkansas at Texas (-8.5) – 57.5 O/U
• 3:30 pm ET – Kentucky at Vanderbilt (-8.5) – 54.5 O/U
• 3:30 pm ET – Duke (-7) at North Carolina – 51.5 O/U (DK Only)
• 3:30 pm ET – USC at Oregon (-10) – 59.5 O/U
• 4 pm ET – TCU at Houston (-1.5) – 55.5 O/U (DK Only)
• 4 pm ET – Kansas State at Utah (-17.5) – 51.5 O/U (DK Only)

FanDuel Only Games: 

• 3:30 pm ET – Syracuse at Notre Dame (-36.5) – 50.5 O/U
• 4 pm ET – Michigan (-14.5) at Maryland – 46.5 O/U
• 7 pm ET – Pittsburgh at Georgia Tech (-2.5) – 61.5 O/U
• 7 pm ET – Nebraska at Penn State (-8.5) – 45.5 O/U
• 7:30 pm ET – Tennessee (-4) at Florida – 57.5 O/U
• 8 pm ET – BYU (-2.5) at Cincinnati – 55.5 O/U

CFB DFS Lineups: Top Plays

Arch Manning, QB, Texas 

DK: $9,000 | FD: $11,200

One of the highest game totals on the slate features Texas as a two-score favorite at home vs. Arkansas. The Longhorns’ offense will be looking to bounce back after being held to 10 points at Georgia last week. That’s especially true for Arch Manning and the passing game in a much easier matchup. Arkansas ranks 108th in the country in passing yards allowed per game, and the secondary has allowed 17 pass TDs over 10 games. The Razorbacks are also giving up 35.7 PPG in conference play. Manning just recently threw for 300+ yards and 3 TDs in back-to-back games, and he can get back to that top-level production. 

Bo Jackson, RB, Ohio State 

DK: $6,600 | FD: $8,800

Ohio State should win big as a massive home favorite vs. Rutgers this week. Normally, that would make us shy away from the Buckeyes’ stars in the blowout scenario. However, Bo Jackson should still get his yards and produce before resting. Rutgers ranks 125th in the sport in rushing yards allowed per game while giving up 6.55 yards per carry (136th). The matchup doesn’t get much better than this. Over the past 7 games, Jackson is averaging 14.6 touches and 87.3 total yards per game as Ohio State’s lead back. CJ Donaldson missed the last game; he could be out or limited again this week, which should keep Jackson in a bigger role. He had 112 yards and a TD on 17 carries last week with Donaldson out. 

Makai Lemon, WR, USC 

DK: $7,600 | FD: $10,600

There aren’t many expensive WRs worth rostering this week, but Makai Lemon tops the list if you want to pay up. The Trojans’ stud wideout has gone off for 161 and 153 receiving yards in the past two games, with 10+ catches in both. He’s averaging 109 yards per game this season and has 10 TDs across 10 games. The USC vs. Oregon matchup projects to be a higher-scoring one with potent offenses on both sides. The Trojans should be throwing a ton while likely trailing on the road. Expect another high-volume performance from Lemon.

CFB DFS Lineups: Value Plays

Miller Moss, QB, Louisville

DK: $5,300 | FD: $8,600

We have two cheap quarterbacks to strongly consider as your Super-Flex this week. Kyron Drones usually provides a safe floor with his rushing, but Miami FL boasts a tough defense. Miller Moss gets the slight nod because of his very favorable matchup. SMU is 135th in the country in passing yards allowed per game (298.6), and the defense has given up 19 pass TDs in 10 games. Louisville likes to lean on the run, but that will be a problem this week as SMU has a top-10 rush defense. So, Miller should be busy passing-wise to rack up yards. He’s coming off a couple of down games, but a return to 25 DK points is certainly possible here. 

Kedrick Reescano, RB, Arizona 

DK: $4,200 | FD: $6,600

The Arizona backfield has been tough to figure out. It looked like Kedrick Reescano was taking over the lead back role, then he had just 5 carries in back-to-back games. Well, Reescano is back on our radar after putting up 94 yards and a TD on 13 carries last week. His rushing volume has fluctuated, but he does have double-digit carries in 3 of the last 5 games. Plus, it appears he’s the lead ball-carrier over Ismail Mahdi. Now, Reescano gets to face a bad Baylor run defense that’s allowing 197.8 rush yards per game (119th in FBS) and 23 rush TDs on the year (124th). 

Kendrick Law, WR, Kentucky 

DK: $4,600 | FD: $6,500

Kendrick Law started the season slow, but he’s picked up the production lately. Kentucky’s top receiver has 17 DK points or more in 4 of his last 6 games. He’s also had 6+ receptions in 4 of the last 6 as well, highlighted by last week’s 11 catches and 124 yards. Law is the clear favorite target for QB Cutter Boley, and the pair can connect often this week. Vanderbilt is giving up 282.3 passing yards per game in conference play (126th in FBS). The matchup is a good one, and UK should be throwing more while trailing on the road here. Plus, Vandy has a strong rush defense, which should force the Wildcats to the air more often. Law can provide a solid floor at some cheap prices. 

Core CFB DFS Lineup Picks: QBs, RBs & WRs