One of the most significant games of Week 13 — and arguably one of the key matchups in the entire College Football Playoff landscape — is set to kick off Saturday afternoon in Eugene. #15 USC is heading to Autzen Stadium to take on #7 Oregon in a contest filled with postseason implications, offensive talent, top-tier quarterback performances, and two programs eager to remain relevant in the national discussion. 

Even though both teams come in with top-15 rankings and offenses that can score against anyone, oddsmakers have set a surprisingly high line. Our #15 USC vs. #7 Oregon picks look to take advantage of just that.

#15 USC vs. #7 Oregon Predictions for College Football Week 13, Saturday, 11/22

With USC receiving nearly double digits, the pressing question is: is Oregon genuinely that much superior, or is the line a product of perception rather than reality? When examining the statistics, it’s clear that Oregon should be the favorite.

The Ducks have shown greater consistency, they have the home advantage, and Dan Lanning’s defense stands out as one of the most formidable units in the Big Ten this season. However, nearly a double-digit spread? That’s where the value sharply shifts in favor of USC, at least, according to our #15 USC vs. #7 Oregon predictions.

 

 

 

#15 USC vs. #7 Oregon Spread Pick: Trojans +9.5 (+105 at Rebet)

This game is expected to be a close contest — not one where a team runs away with a significant lead. For a variety of reasons, USC +9.5 represents an excessive margin. Lincoln Riley’s offense retains its signature explosiveness. USC comes into this matchup averaging 38.2 points per game and is generating big plays at a top-10 national level.

Jayden Maiava has emerged as one of the premier deep ball throwers in the nation, completing almost 60% of his passes that travel 15 or more yards downfield. The receiving duo of Makai Lemon and Ja’Kobi Lane is a dangerous combination that Oregon’s secondary — impressive as it is — has not encountered many equivalents to this season.

USC also demonstrates a strong ability to minimize negative plays. Even with a somewhat unstable offensive line, Riley’s strategy operates swiftly and inventively enough to shield Maiava from pressure.

The Trojans utilize the quick passing game on 33% of their dropbacks, ranking among the highest in the nation, and Maiava has performed remarkably well under pressure, experiencing one of the lowest sack rates in the Big Ten.

When you combine this with USC’s surprisingly effective running game — particularly with the emergence of RB King Miller — the Trojans are likely to consistently achieve first downs and maintain their rhythm. This is crucial for backdoor opportunities, especially in a matchup where the underdog is given nearly a 10-point advantage.

Oregon has moved away from the frenetic, 85-snaps-per-game pace of the Chip Kelly era. Under Lanning and OC Will Stein, the Ducks now exhibit a balanced and patient approach, relying on an elite rushing offense (ranked No. 1 nationally in EPA per rush) and effective intermediate passing from QB Dante Moore.

This more measured tempo naturally reduces the likelihood of blowouts. While USC’s run defense has shown inconsistency, the Trojans have made notable strides under DC D’Anton Lynn.

Their front seven still allows too many early-down lanes, but they excel in tackling at the second level and limit yards after contact more effectively than their reputation would imply. Oregon is bound to score — but if those drives consume 5–7 minutes each, covering a large spread becomes increasingly challenging.

Oregon is likely to win, but USC will keep the score within a touchdown. Our #15 USC vs. #7 Oregon predictions believe that this betting line is simply too high given how closely matched these teams are in terms of explosiveness, efficiency, and quarterback performance.

 

 

 

How To Watch #15 USC vs. #7 Oregon College Football Week 13

  • Date: Saturday, November 22, 2025
  • Time: 3:30 p.m. ET
  • Location: Autzen Stadium — Eugene, OR
  • TV: CBS

#15 USC vs. #7 Oregon Odds, Spreads, Total & Betting Lines

Rebet has unveiled the most recent #15 USC vs. #7 Oregon odds for the matchup set for Saturday afternoon. This comes after our earlier discussions about our #15 USC vs. #7 Oregon predictions:

  • Money Line (ML): Trojans +302 | Ducks -350
  • Spread: Trojans +9.5 (+105) | Ducks -9.5 (-115)
  • Over/Under (O/U): 59.5 (O: -109 | U: -104)

 

 

 

#15 USC vs. #7 Oregon Injury Report & Latest News

USC Injury Report

  • W. Jordan (RB) – Doubtful, Ankle
  • A. Beavers Jr. (LB) – Questionable, Undisclosed
  • P. Brown (CB) – Questionable, Undisclosed
  • J. Jarrett (DL) – Questionable, Undisclosed
  • J. Reed (OG) – Questionable, Undisclosed
  • H. Dalton III (RB) – Questionable, Undisclosed
  • C. Chittenden (K) – Questionable, Undisclosed
  • E. Sanders (RB) – Out, Knee
  • C. Johnson (CB) – Out, Knee

Oregon Injury Report

  • G. Wilson (OG) – Questionable, Undisclosed
  • D. Riggs (RB) – Questionable, Undisclosed
  • J. Ressler (WR) – Questionable, Undisclosed
  • D. Moore (WR) – Questionable, Knee
  • J. Limar (RB) – Questionable, Undisclosed
  • S. Laulea (CB) – Questionable, Undisclosed
  • D. Gresham (WR) – Questionable, Undisclosed
  • G. Bryant Jr. (WR) – Questionable, Ankle
  • T. Gray (DL) – Questionable, Undisclosed
  • K. Kasper (WR) – Out, Undisclosed
  • M. Hughes (RB) – Out, Redshirt
  • B. Boulton (OG) – Out, Undisclosed
  • E. Stewart (WR) – Out, Knee
  • T. McNutt (CB) – Out, Leg

 

 

 

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