The College Football Playoff sees a well-known matchup as #20 Tulane returns to Oxford to take on #6 Ole Miss in the opening round. These two teams faced each other earlier this season, and the outcome was clear: Ole Miss overwhelmed Tulane 45–10 in a game that was essentially decided by halftime.

Now, with even more at stake this go around, the rematch adds more excitement following Lane Kiffin’s exit. That said, there remains a significant talent disparity that strongly favors the Rebels, which our #20 Tulane vs. #6 Ole Miss picks below will highlight.

#20 Tulane vs. #6 Ole Miss Predictions for the CFB Playoffs, Saturday, 12/20

Tulane should be acknowledged for bouncing back from that early-season defeat and successfully navigating through the American to secure a playoff position. However, entering Vaught-Hemingway Stadium against a top-tier SEC team in the playoffs is a completely different challenge. Even with coaching changes on the Ole Miss side, this matchup still appears to favor the Rebels.

Ole Miss giving more than 17 points in a College Football Playoff game might seem unsettling at first glance, but context is crucial when making #20 Tulane vs. #6 Ole Miss predictions. We’ve already witnessed this matchup unfold, and the underlying statistics imply that the initial encounter could have been even more lopsided than the final score suggested.

 

 

 

#20 Tulane vs. #6 Ole Miss Spread Pick: Rebels -17.5 (-104 at FanDuel Sportsbook)

Again, this spread is substantial — and it ought to be.

On September 20, Ole Miss thoroughly outplayed Tulane 45–10 while missing opportunities to score early on. The Rebels outgained Tulane 548–282, averaged nearly eight yards per play, and converted 64% of their third downs.

Tulane’s offense could only muster 104 passing yards, had difficulty maintaining drives, and only reached the end zone late in the game when the outcome was already decided.

What has changed since that game? Tulane has found stability and made improvements — but Ole Miss hasn’t taken a step back.

The Rebels head into the playoffs with an 11–1 record, undefeated at home, and ranked among the top offensive teams in the nation. They average close to 500 yards per game, score 37.3 points per game, and showcase one of the most well-rounded offenses in the country. 

Quarterback Trinidad Chambliss is performing at his peak, coming off a 359-yard, four-touchdown game against Mississippi State, while the rushing attack continues to exploit defenses that fall behind early.

For Tulane to pull off an upset, several factors must align: they need to win the turnover battle, apply consistent pressure without resorting to blitzing, and manage the clock to shorten the game. This strategy proved effective against many teams, but it failed against Ole Miss — and there’s little reason to think it will suddenly succeed now.

On the defensive side, Tulane’s primary challenge continues to be pass coverage. The Green Wave allow significant yardage through the air and depend on physicality and ball control in the late game to stay afloat. 

This tactic is risky against an Ole Miss offense capable of scoring rapidly and pushing opponents out of their comfort zones. Once Tulane finds itself in a position of needing to catch up, their margin for error vanishes.

The coaching narrative actually bolsters Ole Miss’s position. Lane Kiffin’s move to LSU eliminates any chance of complacency. This team is filled with veterans who take pride in their play, have greater aspirations, and have much to prove.

Interim head coach Pete Golding steps into a locker room that is motivated and eager to demonstrate that there is life after Kiffin — and that this season is not solely defined by one individual.

Expect Ole Miss to focus heavily on the run at the start, establish dominance, and allow Chambliss to exploit a Tulane secondary that struggled significantly in their first encounter. Tulane may show more competitiveness for a period, but in terms of depth, speed, and physicality, the Rebels still hold the advantage over four quarters.

While our #20 Tulane vs. #6 Ole Miss predictions will be betting the -17.5, it’s not a slight against Tulane. It acknowledges that Ole Miss has already shown a matchup edge that Tulane has yet to address — and now the stakes are even greater.

 

 

 

How To Watch #20 Tulane vs. #6 Ole Miss - CFB Playoffs

  • Date: Saturday, December 20, 2025
  • Time: 3:30 PM ET
  • TV: TNT / truTV
  • Location: Vaught-Hemingway Stadium, Oxford, Mississippi

#20 Tulane vs. #6 Ole Miss Odds, Spreads, Total & Betting Lines

We have recently published our #20 Tulane vs. #6 Ole Miss predictions. Now, let's examine the most recent #20 Tulane vs. #6 Ole Miss odds for this matchup from FanDuel Sportsbook:

  • Money Line (ML): Green Wave +580 | Rebels -877
  • Spread: Green Wave +17.5 (-118) | Rebels -17.5 (-104)
  • Over/Under (O/U): 56.5 (O: -112 | U: -108)

 

 

 

#20 Tulane vs. #6 Ole Miss Injury Report & Latest News

Tulane Injury Report

  • B. Bohanon (WR) – Doubtful, Undisclosed
  • A. Parham (WR) – Probable, Undisclosed
  • D. Graham (OG) – Probable, Undisclosed
  • M. Hodnett (OG) – Probable, Undisclosed
  • T. Fortenberry (OG) – Probable, Undisclosed
  • D. Jackson (CB) – Probable, Undisclosed
  • M. Igbinoghene (CB) – Probable, Undisclosed
  • J. Sims (CB) – Probable, Undisclosed
  • K. Semonza (QB) – Probable, Undisclosed
  • J. Tchienchou (S) – Probable, Undisclosed
  • C. Helmke (K) – Out, Undisclosed
  • J. Lewis (CB) – Out, Undisclosed
  • G. Henderson (DL) – Out, Undisclosed
  • L. Husbands (TE) – Out, Undisclosed
  • T. Thompson (TE) – Out, Knee
  • D. Agu (LB) – Out, Undisclosed

Ole Miss Injury Report

  • T. Bruckler (TE) – Probable, Undisclosed
  • D. Wright (TE) – Probable, Undisclosed
  • H. Bradley (TE) – Questionable, Undisclosed
  • A. Kite (CB) – Questionable, Undisclosed
  • J. Saunders Jr. (S) – Out, Undisclosed
  • R. Collins (LB) – Out, Undisclosed
  • C. Beavers (CB) – Out, Undisclosed

 

 

 

How To Bet On Tulane vs. Mississippi At FanDuel Sportsbook & Claim Your $300 Bonus

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