The #20 Oregon Ducks will face the #12 USC Trojans in one of the more highly anticipated Week 4 games, featuring two explosive offenses. Oregon, with a record of 2-1, recently suffered a tough 39-31 defeat to Oklahoma State but rebounded with an 84-0 drubbing over Portland State. Quarterback Dante Moore has been impressive, boasting a 9-to-0 touchdown-to-interception ratio and completing 68.5% of his passes.

Meanwhile, USC remains undefeated at 4-0, having secured four consecutive wins to start the season. Jayden Maiava has thrown for 12 touchdowns with only one interception, leading the Trojans to an average of around 43 points per game. Given the offensive strengths of both teams and the inconsistency of their defenses, this game seems destined to be a high-scoring affair, which is something our #20 Oregon vs. #12 USC picks will highlight. 

#20 Oregon vs. #12 USC Predictions for CFB Week 4, Saturday, 9/26

The upcoming matchup is likely to create plenty of scoring opportunities, as USC has been one of the most effective offenses this season, scoring at least 39 points in every game. Additionally, Oregon's offense is expected to continue to play at a high level. We talk about the QBs in the introduction just to say that the most promising play for this game is Waymond Jordan to score a touchdown at +105 for #20 Oregon vs. #12 USC odds on DraftKings Sportsbook.

As the #2 back for USC, Jordan's ability to reach the end zone effectively when given the chance, combined with this matchup, could be a great opportunity for him to reach paydirt. Although he has just one touchdown in four games this season, his performance in 2025 suggests he’s due to find the end zone soon in 2026, so why not against Oregon? Our #20 Oregon vs. #12 USC predictions will get into exactly that…

#20 Oregon vs. #12 USC Expert Pick: Waymond Jordan Anytime TD (+105 at DraftKings Sportsbook)

Last season, Jordan had 88 carries for 576 rushing yards, averaging 6.5 yards per carry, and scored five rushing touchdowns in just six games, along with seven receptions for 55 yards. Through the first four games of the season, Jordan has recorded 37 carries for 188 yards, averaging 5.1 yards per carry, and has one rushing touchdown. He’s also caught four passes for 37 yards. 

Jordan hasn't scored many touchdowns yet, but his spot in the USC offense brings about a strong chance to change that against Oregon. USC is expected to reach the red zone multiple times against this Oregon defense. Even if the Trojans focus on being pass-first, Jordan doesn't need a heavy workload to score; he just needs some goal-line opportunities.

Plus, USC may need to maintain an aggressive approach instead of just defending a lead, especially if Oregon manages to move the ball well. This could help lead to numerous offensive opportunities for the Trojans throughout the game. 

With the total set at 61.5 points, the expectations are that this is a high-scoring, back-and-forth type of contest. Instead of our #20 Oregon vs. #12 USC picks trying to guess the final score, Jordan's +105 anytime touchdown odds present a perfect way to capitalize on this anticipated scoring.

He’s gotten off to a slower start this season, but Jordan is due to break out at any moment, and facing this Duck defense might just be exactly what he needs. Given USC's consistent scoring as well (39+ points in every game) and Oregon's lack of defense, our #20 Oregon vs. #12 USC predictions believe that this could be the perfect opportunity for Jordan to add to his touchdown tally for 2026.

 

 

 

How To Watch #20 Oregon vs. #12 USC - CFB Week 4

  • Date: Saturday, September 26
  • Time: 7:30 p.m. ET
  • Location: Los Angeles Memorial Coliseum, Los Angeles, CA
  • TV: NBC

#20 Oregon vs. #12 USC Odds, Spreads, Total & Betting Lines

As we get ready for the exciting matchup featuring our #20 Oregon vs. #12 USC predictions, it's important to check the latest #20 Oregon vs. #12 USC odds from DraftKings Sportsbook for this game:

  • Money Line (ML): Ducks -166 | Trojans +140
  • Spread: Ducks -3 (-112) | Trojans +3 (-108)
  • Over/Under (O/U): 61.5 (O: -110 | U: -110)

 

 

 

#20 Oregon vs. #12 USC Injury Report & Latest News

Oregon Injury Report

  • J. Lott, WR - Doubtful (Hand)
  • K. Harrison, TE - Probable (Undisclosed)
  • J. Johnson, TE - Probable (Undisclosed)
  • J. McClellan, WR - Out (Foot)
  • D. Gresham, WR - Questionable (Neck)
  • S. Price, RB - Questionable (Undisclosed)
  • I. Hooks, WR - Questionable (Undisclosed)

USC Injury Report

  • C. Simms, WR - Out (Undisclosed)
  • K. Reddick, S - Questionable (Undisclosed)
  • D. Redeaux, RB - Probable (Undisclosed)
  • T. Mosley, WR - Out (Knee)
  • S. Huard, QB - Questionable (Undisclosed)
  • R. Tezeno, WR - Questionable (Foot)
  • R. Ison, WR - Questionable (Undisclosed)
  • K. O'Connor, OG - Out (Undisclosed)

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