It's a classic late-season clash in the Steel City as the #9 Notre Dame Fighting Irish (7-2) make their way to Acrisure Stadium to take on the #22 Pittsburgh Panthers (7-2) in a crucial Week 12 encounter.

Both teams are still in the mix for the College Football Playoff, and a loss here would likely extinguish those aspirations. Notre Dame enters this matchup as 11.5-point favorites at FanDuel Sportsbook, but could that figure be inflated for a road game against a genuine top-25 contender? Let’s see what our #9 Notre Dame vs. #22 Pitt picks have to say.

#9 Notre Dame vs. #22 Pitt Predictions for College Football Week 12, Saturday, 11/15

Notre Dame has cruised through much of its schedule, overpowering unranked teams while occasionally showing signs of weakness against better competition. On the other hand, Pitt has been steadily gaining momentum. They have the feel of a squad that’s being underestimated despite its well-rounded play and capability to challenge any team in the country.

Kickoff is scheduled for Saturday, November 15, at 12:00 p.m. ET on ABC. Considering the circumstances, the environment, and the motivational edge, our #9 Notre Dame vs. #22 Pitt predictions believe that this presents a compelling chance for Pitt to either cover the spread or potentially pick up a massive upset win.

 

 

 

#9 Notre Dame vs. #22 Pitt Spread Pick: Panthers +11.5 (-106 at FanDuel)

The Irish have certainly appeared dominant on paper. They’re averaging 38.7 points per game (10th in the nation) and rank third in yards per play (7.3). Freshman quarterback CJ Carr continues to shine, throwing three touchdowns on just 16 attempts during last week’s 49-10 victory over Navy. His composure and accuracy are already among the best in the nation for a young quarterback.

However, this dominance has primarily come against weaker defenses. When Notre Dame has faced tougher competition — games against Miami, Texas A&M, and even USC — they have struggled to maintain drives against teams that can match their physicality. Pitt fits that description.

The Panthers rank near the top of the nation for yards allowed per rush (2.4), a stat that could push Notre Dame into more predictable passing situations than they’d like. Under offensive coordinator Mike Denbrock, the Irish excel when they can establish a strong running game with Jeremiyah Love and Jadarian Price, which sets up Carr for deep play-action opportunities.

The issue? Pitt’s front seven is tough to move. When opponents stack the box against Notre Dame, their production drops significantly — and Pitt has allowed only 3.6 yards per attempt with seven or more defenders in the box, placing them in the top 30 nationally. Notre Dame’s offensive line will still have its moments, but Pitt’s interior strength can disrupt their rhythm and keep this game competitive.

While Notre Dame may boast more raw talent, the situational factors clearly favor the home team. This is certainly Pitt’s most significant game of the season — a ranked home contest in front of a full Acrisure Stadium, attracting national attention and playoff stakes.

Pitt stands at 7-2 ATS overall, excelling in the underdog position. With the Panthers’ defense capable of curbing Notre Dame’s rushing attack and Mason Heintschel ready to connect on enough deep throws, the conditions are ripe for a cover — or even a potential upset in the closing moments. We’ll ride the Panthers in our #9 Notre Dame vs. #22 Pitt predictions.

 

 

 

How To Watch #9 Notre Dame vs. #22 Pitt College Football Week 12

  • Date: Saturday, November 15, 2025
  • Time: 12:00 p.m. ET
  • Location: Acrisure Stadium — Pittsburgh, Pennsylvania
  • TV: ABC

#9 Notre Dame vs. #22 Pitt Odds, Spreads, Total & Betting Lines

FanDuel Sportsbook has released the latest #9 Notre Dame vs. #22 Pitt odds for the matchup scheduled for Saturday afternoon. This is following our previous talks regarding our #9 Notre Dame vs. #22 Pitt predictions for the game:

  • Money Line (ML): Fighting Irish -490 | Panthers +380
  • Spread:Fighting Irish -11.5 (-114) | Panthers +11.5 (-106)
  • Over/Under (O/U): 55.5 (O: -108 | U: -112)

 

 

 

#9 Notre Dame vs. #22 Pitt Injury Report & Latest News

Notre Dame Injury Report

  • D. Hinish (DL) – Questionable, Undisclosed
  • J. Greathouse (WR) – Questionable, Thigh
  • M. Gilbert (WR) – Questionable, Hand
  • C. Flanagan (TE) – Questionable, Achilles
  • S. Sevillano Jr. (DL) – Out, Ankle
  • G. Rubio (DL) – Out, Elbow
  • P. Jones (OG) – Out, Ankle
  • C. Jagusah (OG) – Out, Arm
  • N. Burnette (K) – Out, Hip
  • B. Schrauth (OG) – Out, Knee
  • A. Craig (OG) – Out, Knee
  • K. Young (RB) – Out, Knee
  • B. Logan (S) – Out, Shoulder
  • D. Devezin (RB) – Out, Shoulder

Pittsburgh Injury Report

  • C. Brookins (CB) – Questionable, Undisclosed
  • B. Spires (DL) – Questionable, Undisclosed
  • N. Lapi (LB) – Questionable, Undisclosed
  • R. Biles (LB) – Questionable, Undisclosed
  • J. Persi (OG) – Questionable, Undisclosed
  • N. Maynard (CB) – Questionable, Undisclosed
  • J. Brown (RB) – Questionable, Undisclosed
  • D. Cook (DL) – Questionable, Undisclosed
  • D. Reid (RB) – Questionable, Undisclosed
  • Z. Crothers (DL) – Out, Undisclosed
  • K. Gouveia (OG) – Out, Leg
  • J. Marcelin (LB) – Out, Undisclosed
  • J. Bonsu (LB) – Out, Undisclosed
  • D. Davis Jr. (RB) – Out, Knee

 

 

 

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