Few rivalries in college football provide the same level of drama, intensity, and narratives as Miami vs. Florida State. Over the years, the Hurricanes and Seminoles have engaged in a number of memorable matchups, and their Week 6 clash in Tallahassee in 2025 is poised to be another significant moment. 

With high stakes and both fanbases anticipating an exciting game, Saturday night at Doak Campbell Stadium promises to be unmissable television. With that brings about our #3 Miami vs. #18 Florida State predictions!

#3 Miami vs. #18 Florida State Predictions for College Football Week 6, Saturday, 10/4

Miami comes in undefeated and holds the No. 3 ranking, while Florida State aims to bounce back after suffering its first defeat of the season. This line initially opened closer to a touchdown, but early betting activity adjusted it to Miami -4.5. 

This minor shift doesn’t alter the reality on the field, or in our #3 Miami vs. #18 Florida State picks: Miami is the more well-rounded football team, and the Hurricanes possess the talent to secure a victory in this rivalry game by a touchdown or more.

 

 

 

#3 Miami vs. #18 Florida State Spread Pick: Hurricanes -4.5 (-110 at Rebet)

Defense travels, and Miami’s defensive unit is top-notch. Over the course of four games, the Hurricanes are limiting their opponents to just 11.5 points per game and only 2.6 yards per rush. 

That front seven, spearheaded by Rueben Bain Jr., appears to be one of the most disruptive in college football. Bain is already being compared to Aaron Donald, and his knack for disrupting plays in the backfield could be crucial against Florida State’s powerful run game.

Florida State’s offense appears formidable on paper – averaging 53 points per game and over 600 total yards – but those numbers are inflated due to matchups with weaker defenses.

When challenged by Virginia last week, the Seminoles racked up yards but also revealed vulnerabilities in pass protection and struggled to consistently finish drives. Miami won’t be as lenient.

To add to our argument, Miami quarterback Carson Beck is becoming more at ease in Shannon Dawson’s system. After four games, he has nearly 1,000 passing yards and seven touchdowns, demonstrating composure even in challenging settings, such as earlier this season at Notre Dame.

His skill in distributing the ball to playmakers like Malachi Toney and CJ Daniels will put pressure on Florida State’s secondary, which has shown opportunism at times but also has its weaknesses.

The Hurricanes can rely on Beck’s decision-making, supported by running back Mark Fletcher Jr., who has nearly 400 rushing yards. This balanced offensive strategy should compel Florida State to make some tough decisions, and given that their defense allowed 211 rushing yards to Virginia, Miami has several ways to advance the ball.

On the other side, though, Tommy Castellanos and Gavin Sawchuk lead a Florida State offense capable of exploiting defenses on the ground. Sawchuk averages over five yards per carry, while Castellanos poses a threat as both a passer and a runner. With USC transfer Duce Robinson at wide receiver, the Seminoles do indeed possess explosive talent.

The issue? Consistency. In their game against Virginia, the Seminoles scored plenty of points but also allowed 46 in a double-overtime defeat. This highlighted their defense's vulnerabilities against better competition. Now, they’re up against a Miami offense that is more efficient, deeper, and led by a quarterback with significant big-game experience.

The home crowd at Doak Campbell Stadium will provide Florida State with a lift, but Miami is equipped to manage it. The Hurricanes’ defense is too disciplined, and their offense too well-rounded, to allow this game to turn into a shootout.

Expect Florida State to stay competitive early on, but over the course of four quarters, Miami’s depth and defensive strength should give them the edge. Our #3 Miami vs. #18 Florida State predictions will gladly lay the points with the Hurricanes.

 

 

 

How To Watch #3 Miami vs. #18 Florida State College Football Week 6

  • Date: Saturday, October 4, 2025
  • Time: 7:30 p.m. ET
  • Location: Doak Campbell Stadium, Tallahassee, FL
  • TV: ABC

#3 Miami vs. #18 Florida State Odds, Spreads, Total & Betting Lines

In accordance with our previous #3 Miami vs. #18 Florida State predictions, we now present the most recent #3 Miami vs. #18 Florida State odds for the game from Rebet:

  • Money Line (ML): Hurricanes -195 | Seminoles +160
  • Spread: Hurricanes -4.5 (-110) | Seminoles +4.5 (-110)
  • Over/Under (O/U): 54 (O: -110 | U: -110)

 

 

 

#3 Miami vs. #18 Florida State Injury Report & Latest News

Miami Injury Report

  • J. Trader (WR) – Questionable, Undisclosed
  • J. Lyle (RB) – Questionable, Undisclosed

Florida State Injury Report

  • A. Barker (CB) – Questionable, Shoulder
  • R. Williams (RB) – Questionable, Undisclosed
  • G. Markey (QB) – Questionable, Undisclosed
  • D. Diggs (DL) – Questionable, Undisclosed
  • C. Loftin (TE) – Questionable, Undisclosed
  • K. Davis (RB) – Questionable, Undisclosed
  • C. LaVallee (LB) – Questionable, Undisclosed
  • J. Boggs (WR) – Questionable, Undisclosed
  • E. Pritchard (LB) – Out, Undisclosed

 

 

 

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