The SEC may be focused on Alabama vs. Georgia, but don’t forget about what’s going down in Oxford this weekend. No. 4 LSU and No. 13 Ole Miss are both undefeated and fighting for more than just some early bragging rights. The team that wins this game will take a big step toward remaining in the SEC title race, while the loser risks falling behind in the College Football Playoff hunt.

Last year’s game was unforgettable, and these two teams are known for creating exciting matchups. With a very close spread and both offenses ready to make big plays, this is looking like one of the must-see games of Week 5, setting up some intriguing #4 LSU vs. #13 Ole Miss picks.

#4 LSU vs. #13 Ole Miss Predictions for College Football Week 5, Saturday, 9/27

At first glance, this seems like a game that could go either way. LSU has the reputation, the star players, and a defense that has shown moments of greatness. On the other hand, Ole Miss has the advantage of playing at home and a quarterback named Trinidad Chambliss, who has quickly become one of the most exciting playmakers in the SEC.

With the spread set at just -1.5, bettors really need to consider one main question: Do you have faith in the road favorite or the home underdog? Our #4 LSU vs. #13 Ole Miss predictions are going with the Rebels at home.

 

 

 

#4 LSU vs. #13 Ole Miss Spread Pick: Rebels -1.5 (-115 at BetMGM)

The first point is LSU’s track record. Sure, the Tigers are 4-0, but those “big wins” against Clemson and Florida don’t seem as impressive now. Clemson is still trying to sort out its, well, everything, and Florida’s offense has been struggling since Week 1. Winning against teams that are having a tough time doesn’t hold the same significance as it might have back in August.

On the flip side, Ole Miss has managed to win close games against Kentucky and Arkansas, and they dominated a decent Tulane team with a score of 45-10. Lane Kiffin’s team has shown they can bounce back in tight situations and be explosive when the matchups are right. That adaptability makes them a threat, especially in a home setting like Vaught-Hemingway Stadium, where the crowd will be excited for a top-5 opponent under the lights.

Chambliss has been nothing short of amazing since he transferred in. In the game against Tulane, he racked up over 400 total yards and four touchdowns. His knack for extending plays with his legs and making deep throws keeps defenses on their toes.

LSU’s defensive line, led by Jacobian Guillory II and Harold Perkins, can create pressure. However, the Tigers haven’t yet faced a dual-threat quarterback with Chambliss’s mix of experience and explosiveness. If Ole Miss can maintain a fast pace and turn the game into a track meet, it’ll benefit the Rebels.

Naturally, LSU has its share of strengths. Garrett Nussmeier has been reliable, and the Tigers’ wide receiver corps can really stretch the field in ways that few defenses can cope with. If he has enough time, Nussmeier could easily shine against an Ole Miss defense that has had trouble getting off the field.

Brian Kelly’s team might also consider relying more on the run game. Ole Miss has allowed over five yards per carry this season, and if LSU commits to running the ball, it could slow the game down and keep Chambliss off the field. Still, LSU has been hesitant to run consistently, preferring to trust Nussmeier’s passing skills instead. Against Ole Miss, finding that balance could be crucial for either a close win or a narrow loss.

In recent years, this series has heavily favored the home team. Six out of the last seven matchups have been won by the team playing at home. This isn’t just a coincidence – the atmosphere in Oxford has turned into a real SEC advantage, and with both teams being so evenly matched, that extra support could be the key factor.

Both teams are undefeated, both are packed with talent, and both have dreams of the College Football Playoff. But LSU’s notable wins don’t seem as impressive when looking back, while Ole Miss has the quarterback, the tempo, and the home field to sway this closely contested matchup. Let’s back the Rebels -1.5 to defend their home turf and make another statement in the SEC with our #4 LSU vs. #13 Ole Miss predictions.

 

 

 

How To Watch #4 LSU vs. #13 Ole Miss College Football Week 5

  • Date: Saturday, September 27, 2025
  • Kickoff: 3:30 p.m. ET
  • Location: Vaught-Hemingway Stadium, Oxford, MS
  • TV Broadcast: ABC

#4 LSU vs. #13 Ole Miss Odds, Spreads, Total & Betting Lines

Following our previous talk regarding the official #4 LSU vs. #13 Ole Miss predictions, here are the latest #4 LSU vs. #13 Ole Miss odds from BetMGM Sportsbook for the matchup on Saturday night:

  • Money Line (ML): Tigers +105 | Rebels -125
  • Spread: Tigers +1.5 (-105) | Rebels -1.5 (-115)
  • Over/Under (O/U): 56.5 (O: -105 | U: -115)

 

 

 

#4 LSU vs. #13 Ole Miss Injury Report & Latest News

LSU Injury Report

  • D. Chester (OG) – Probable, Suspension
  • G. Reliford (DL) – Out, Undisclosed
  • W. Weeks (LB) – Probable, Undisclosed
  • T. Green (TE) – Probable, Knee
  • C. Durham (RB) – Questionable, Ankle
  • J. Lindsey (RB) – Out, Suspension

Ole Miss Injury Report

  • J. Braxton (CB) – Probable, Undisclosed
  • J. Saunders Jr. (S) – Questionable, Undisclosed
  • D. Price (WR) – Out, Undisclosed

 

 

 

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