Michigan travels to Lincoln this Saturday for a pivotal Big Ten clash against the unbeaten Nebraska Cornhuskers. This matchup marks the conference opener for both squads, and the implications are significant. 

Nebraska has been scoring prolifically in the first three weeks, but Michigan poses the toughest challenge they’ve faced so far this season. Meanwhile, the Wolverines aim to bounce back after an early setback against Oklahoma, and there are still doubts regarding the consistency of their offense under pressure. 

Let’s explore the best #21 Michigan vs. Nebraska picks, injury updates, and how to catch this high-profile matchup!

 

 

 

#21 Michigan vs. Nebraska Predictions for College Football Week 4, Saturday, 9/20

This matchup is nearly a toss-up on the Week 4 schedule. Computer simulations slightly favor Nebraska, yet sportsbooks still have Michigan as a slight favorite on the road. 

Both teams are skilled, both have their weaknesses, and both urgently need a victory to maintain their hopes for a conference title and playoff berth. Anticipate a tough, hard-fought contest in Lincoln, where our #21 Michigan vs. Nebraska predictions focus on the total.

 

 

 

#21 Michigan vs. Nebraska Best Bet: Under 47.5 (-110 at DraftKings Sportsbook)

On the surface, Nebraska appears to be an offensive powerhouse. Sophomore quarterback Dylan Raiola has been outstanding, completing 77% of his passes with eight touchdowns and no interceptions. Nebraska is currently ranked 12th in the nation, averaging 49 points per game. However, context is crucial.

The Cornhuskers have dominated teams like Akron, Houston Christian, and Cincinnati — not exactly known for their strong defenses. Even against Cincinnati, Nebraska's scoring was hindered, and Raiola had to work hard for every yard. Going up against Michigan's defense will present a completely different set of challenges.

The Wolverines' defensive line has been relentless. They allow only 2.6 yards per carry and typically generate multiple turnovers each game. Even in their defeat against Oklahoma, it wasn't the defense that faltered; it was the offense's failure to maintain drives.

Brent Venables' squad had to fight tooth and nail to accumulate 400 total yards, and Michigan made every yard hard-earned. Nebraska's offensive line has yet to encounter this level of pressure, and Raiola will need to perform flawlessly to steer clear of errors.

 

 

 

Currently, Michigan's offense is still developing. Freshman quarterback Bryce Underwood showcased his playmaking skills against weaker teams, but when the Wolverines faced Oklahoma in Norman, he appeared to struggle.

Completing only nine of 24 passes without any touchdowns is insufficient against high-caliber squads. While Nebraska's defense may not be as formidable as Oklahoma's, it’s still capable of exploiting Michigan's vulnerable offensive line and erratic passing game.

This leads us to the total points. At 47.5, the over seems achievable, yet the matchup strongly suggests an UNDER outcome. Nebraska's impressive offensive statistics are unlikely to translate effectively against Michigan's speed and toughness.

Conversely, Michigan is not designed to score heavily while playing away from The Big House. Their best strategy for a win here involves relying on their running game, controlling the clock, and keeping Raiola off the field.

Nebraska's strong start has been noteworthy, but Michigan's defensive reputation combined with Nebraska's lack of top-tier opponents thus far leans this matchup towards a physical showdown. Anticipate turnovers and lengthy drives culminating in field goals. The best bet for #21 Michigan vs. Nebraska predictions? Stick with the Under 47.5.

 

 

 

How To Watch #21 Michigan vs. Nebraska College Football Week 4

  • Date: Saturday, September 20, 2025
  • Time: 3:30 PM ET
  • TV: CBS
  • Location: Memorial Stadium, Lincoln, Nebraska

 

 

 

#21 Michigan vs. Nebraska Odds, Spreads, Total & Betting Lines

In light of our #21 Michigan vs. Nebraska predictions, we’re providing the most recent #21 Michigan vs. Nebraska odds from DraftKings Sportsbook for this matchup:

  • Money Line (ML): Wolverines -112 | Cornhuskers -108
  • Spread: Wolverines -0.5 (-112) | Cornhuskers +0.5 (-108)
  • Over/Under (O/U): 47.5 (O: -110 | U: -110)

 

 

 

#21 Michigan vs. Nebraska Injury Report & Latest News

Michigan Injury Report

  • D. Warren (QB) – Questionable, Knee
  • J. Volker (RB) – Questionable, Undisclosed
  • I. Stewart (WR) – Questionable, Undisclosed
  • B. Norton (OG) – Questionable, Undisclosed
  • T. Metcalf (CB) – Questionable, Undisclosed
  • M. Ka'apana (RB) – Questionable, Undisclosed
  • D. Johnson (RB) – Questionable, Undisclosed
  • J. Hood (LB) – Questionable, Undisclosed
  • G. El-Hadi (OG) – Questionable, Undisclosed
  • C. Charleston (WR) – Questionable, Undisclosed
  • D. Baxter (DL) – Questionable, Undisclosed
  • C. Anderson (CB) – Questionable, Undisclosed
  • Z. Berry (CB) – Questionable, Undisclosed
  • I. Iwunnah (DL) – Questionable, Undisclosed
  • R. Moore (CB) – Questionable, Undisclosed
  • M. Keene (QB) – Questionable, Undisclosed
  • A. Babalola (OG) – Out, Knee

 

Nebraska Injury Report

  • M. Simpson (DL) – Questionable, Undisclosed
  • T. Terry (DL) – Questionable, Undisclosed
  • J. Parker (RB) – Questionable, Undisclosed
  • J. Jones (WR) – Questionable, Undisclosed
  • J. Marks (OG) – Questionable, Undisclosed
  • T. Uhlir (RB) – Questionable, Undisclosed
  • N. Fennessy (OG) – Questionable, Undisclosed
  • C. Connealy (DL) – Questionable, Undisclosed
  • D. Bell (WR) – Questionable, Knee
  • J. Bonner (WR) – Questionable, Undisclosed
  • G. Brix (OG) – Questionable, Undisclosed
  • J. Rhett (CB) – Questionable, Undisclosed
  • M. Hartzog Jr. (CB) – Questionable, Undisclosed
  • J. Wright (LB) – Questionable, Undisclosed
  • G. Pyle (OG) – Out, Knee
  • B. Hill (CB) – Out, Knee
  • G. Stenger (LB) – Out, Undisclosed
  • M. Markway (TE) – Out, Knee

 

 

 

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