The focus turns to Norman, Oklahoma, in Week 2 for what seems like a playoff game in September. Two prestigious teams, each with new quarterbacks and fresh goals, face off as the Michigan Wolverines take on the Oklahoma Sooners this Saturday night.

Michigan comes in wanting to show that last season's struggles were just a minor setback, while Oklahoma has to demonstrate that Brent Venables' team is ready to regain its place in the national spotlight. Let’s make some #15 Michigan vs. #18 Oklahoma picks, shall we?

 

 

 

#15 Michigan vs. #18 Oklahoma Predictions for College Football Week 2, Saturday, 9/6

Both teams kicked off 2025 with victories — Michigan defeated New Mexico 34–17 with true freshman quarterback Bryce Underwood leading the way, and Oklahoma dominated Illinois State 35–3 with transfer QB John Mateer at the helm — but this primetime matchup will serve as the first true test for both teams.

If there's one thing bettors can count on in Norman, it's that the game will be close. Oklahoma is a worthy home favorite, but Michigan getting +4.5 points seems like the better value when looking to make #15 Michigan vs. #18 Oklahoma predictions.

 

 

 

#15 Michigan vs. #18 Oklahoma Spread Pick: Wolverines +4.5 (-110 at DraftKings Sportsbook)

Both teams have new quarterbacks, and their first games showed some exciting potential for the season. Mateer was impressive for Oklahoma, throwing for 392 yards and three touchdowns, plus rushing for another score in his first game. 

He proved why some experts see him as a real Heisman contender. The Sooners' passing game looked much better than last year's injury-plagued squad, with healthy receivers finally able to stretch the field vertically.

On the other hand, our #15 Michigan vs. #18 Oklahoma predictions have to take into account that Michigan's offensive changes are just as fascinating. Underwood, the top recruit in the nation, completed 21 of 31 passes for 251 yards and a touchdown in his debut. 

For a team that was among the lowest in the country for passing last year, that's a huge improvement. With Alabama transfer Justice Haynes, who rushed for 159 yards and three touchdowns in Week 1, Michigan now has a balanced offense that can challenge even the best defenses.

The issue? Both defenses are going to put them to the test in ways their Week 1 opponents didn’t. Brent Venables has a strong, talented defensive line that should put pressure on Underwood. Meanwhile, Michigan's defensive line is the core of its team, and although the Wolverines didn’t fully use their blitz strategies against New Mexico, they’ll have something ready for Mateer.

 

 

 

This game probably won’t be decided by big plays, but by which team can avoid mistakes. Freshman quarterbacks on the road are always a worry, but Underwood doesn’t act like a typical freshman. Analysts praise his maturity and calmness, and Michigan doesn’t need him to be amazing — just effective. The run game and defense are set up to keep this game close.

Another important aspect is motivation. For Oklahoma, this matchup marks the beginning of a tough SEC schedule featuring teams like Texas, Alabama, and LSU. Losing at home in Week 2 could make their chances of reaching the playoffs nearly impossible. On the other hand, Michigan’s schedule becomes easier after this game. If they win in Norman, the Wolverines could be on track for a season with double-digit victories.

We can expect a close, low-scoring match where both quarterbacks show their skills, but neither offense really takes control. A score around 24–21 seems likely, and in that case, Michigan +4.5 would cover even if Oklahoma manages to win. When games are projected to be this close, betting on the underdog with the points is usually the smart choice, which is what we’re doing in our #15 Michigan vs. #18 Oklahoma picks.

 

 

 

How To Watch #15 Michigan vs. #18 Oklahoma College Football Week 2

  • Date: Saturday, Sept. 6, 2025
  • Time: 7:30 p.m. ET
  • Location: Memorial Stadium, Norman, OK
  • TV Broadcast: ABC

 

#15 Michigan vs. #18 Oklahoma Odds, Spreads, Total & Betting Lines

Based on our official #15 Michigan vs. #18 Oklahoma predictions mentioned above, here are the most recent #15 Michigan vs. #18 Oklahoma odds from DraftKings Sportsbook:

  • Money Line (ML): Wolverines +170 | Sooners -205
  • Spread: Wolverines +4.5 (-110) | Sooners -4.5 (-110)
  • Over/Under (O/U): 43.5 (O: -115 | U: -105)

 

 

 

#15 Michigan vs. #18 Oklahoma Injury Report & Latest News

 

Michigan Injury Report

  • None

Oklahoma Injury Report

  • None

 

 

 

How To Bet On Michigan vs. Oklahoma At DraftKings Sportsbook & Claim Your $200+ Bonus

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