The 2026 college football season rolls on! Saturday’s matchup between #8 Florida and #25 Missouri headlines CFB Week 5. That means it’s time to dive into #8 Florida vs. #25 Missouri predictions before kickoff. We’ll preview the game, break down the matchup, and dish out expert #8 Florida vs. #25 Missouri picks. Plus, get to know the latest #8 Florida vs. #25 Missouri odds ahead of Saturday’s showdown. 

 

#8 Florida vs. #25 Missouri Predictions for CFB Week 5, Saturday 10/3

Before we get to our #8 Florida vs. #25 Missouri predictions, let’s set the stage for Saturday’s game. Florida enters as the 5-point road favorite with a 57.5 over/under on BetMGM Sportsbook. The Gators (4-0) are riding high coming off a big win over Ole Miss last week. Meanwhile, Mizzou (3-1) will look to bounce back after losing to Mississippi State. 

Without further ado, let’s dive into our #8 Florida vs. #25 Missouri picks. There’s a certain betting angle worth locking in before Saturday’s matchup kicks off. Good luck! 

 

 

 

#8 Florida vs. #25 Missouri Expert Pick: Over 57.5 Total Points (-110 on BetMGM Sportsbook)

Florida is the deserving road favorite, but Missouri is a live dog to pull off the upset. While it’s tempting to back the Tigers to cover or win outright, let’s ignore the spread. Instead, grab the over as this projects to be a higher-scoring matchup. 

The Gators boast one of the most potent offenses in the country. Florida averages 53.5 points per game and 532.8 total yards per contest. Both are top-5 marks in the sport. The offense also ranks 1st nationally in EPA/Play and 9th in success rate. 

Auburn and Ole Miss found out the hard way how prolific this offense can be. The Gators put up 52 and 44 points in those past two victories. Running back Jadan Baugh is firmly in the Heisman conversation with 11 touchdowns through four games while averaging 150 rushing yards per week. Quarterback Aaron Philo owns a 72% completion rate while running an efficient passing attack. 

Missouri’s defense has been mostly strong this season, but it also hasn’t faced an offense like Florida’s yet. In last week’s loss to Mississippi State, the Mizzou defense allowed 499 total yards and 31 points. The Tigers notably struggled to stop tailback Fluff Bothwell, who racked up 122 yards on 4.9 yards per carry. That spells trouble against Baugh this week. 

Meanwhile, Missouri should put up points as well. Florida has had some defensive issues this season. The Gators rank 101st nationally in defensive EPA/Play and 111th in defensive success rate. They were able to outscore Auburn and Ole Miss, but also gave up 39 and 28 points, respectively. 

As for Mizzou, its passing attack can exploit some of Florida’s struggles on defense. Quarterback Austin Simmons is playing well for the Tigers, and he has multiple receiving weapons to throw to – led by Cayden Lee and Donovan Olugbode. The run game is also strong, with Jamal Roberts averaging 116 rushing yards over the past three games. 

 

 

 

How To Watch #8 Florida vs. #25 Missouri CFB Week 5

  • Date: Saturday, October 2, 2026
  • Time: 3:30 PM ET 
  • Location: Memorial Stadium, Columbia, Missouri
  • TV: ABC

 

#8 Florida vs. #25 Missouri Odds, Spread, Total & Betting Lines

After checking out our #8 Florida vs. #25 Missouri predictions, let’s take a look at the betting lines for this college football matchup. Here are the latest #8 Florida vs. #25 Missouri odds from BetMGM Sportsbook ahead of Saturday’s showdown. 

  • Spread: Florida -5 (-118) | Missouri +5 (-108)
  • Moneyline: Florida -220 | Missouri +180
  • Over/Under: 57.5 (Over -110 | Under -108)

 

#8 Florida vs. #25 Missouri Injury Report & Latest News

Florida Gators:

  • WR Vernell Brown III – Questionable
  • WR Bailey Stockton – Questionable 

Missouri Tigers:

  • RB Ahmad Hardy – Out
  • DE Darris Smith – Questionable
  • DE Langden Kitchen – Questionable
  • LB Bobby Washington – Questionable
  • RB Malae Fonoti – Out
  • RT Josh Atkins – Out
  • S JaDon Blair – Out
  • TE Gavin Hoffman – Out

 

 

 

How To Bet On #8 Florida vs. #25 Missouri at BetMGM Sportsbook & Claim Your $1,500 Bonus 

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