Ryan Mathews, RB
While injuries are impossible to predict, there are certain players who have a long-standing track record of being bitten by the injury bug and Mathews should be considered the poster child. When healthy, he's proven to be a capable runner and even a bit of a red zone threat. However, he's played a full 16-game slate just once in his career and has appeared in just 19 of a possible 32 games over the last two seasons. The Eagles obviously had enough faith in him to let DeMarco Murray walk, but they also hedged with their selection of Wendell Smallwood in the fifth round of the 2016 NFL Draft. Be careful of drafting Mathews too high and if you do, make sure you have plenty of back-up options, including a Smallwood handcuff.