The 2025 NFL season continues with a thrilling Week 1 Friday Night Football matchup between the Los Angeles Chargers and Kansas City Chiefs at Corinthians Arena in Sao Paulo, Brazil, on September 5, 2025. 

For fantasy users diving into Underdog NFL Pick'em, I’ve outlined key player forecasts and game breakdowns to guide your selections for this AFC West showdown. 

Below are my Underdog NFL Pick'em spotlights, focusing on sleeper quarterbacks, high-impact running backs, and under-the-radar wide receivers who could exceed expectations and give you an edge in this high-stakes opener.

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Xavier Worthy Underdog NFL Pick: Higher than 3.5 Rushing Yards

Xavier Worthy, the Chiefs' dynamic speedster, thrives in their versatile offense, which deploys him in multiple ways. 

In his 2024 rookie season, he recorded 20 carries over 17 games, surpassing 3.5 rushing yards in 10 of those contests. Kansas City’s creative play-calling goes beyond simple end-arounds, incorporating Worthy in diverse rushing schemes. 

With his blazing 4.21-second 40-yard speed, he’s a threat for a breakout run. Let’s see if Worthy can ignite the ground game with a big play.

 

 

 

Will Dissly Underdog NFL Pick: Higher than 6.5 1st Half Receiving Yards

Targeting the Chiefs' weakness against tight ends, who allowed the most yards and second-most receptions last season, Will Dissly is a strong pick for over 6.5 first-half receiving yards. 

With Kansas City likely focusing on Ladd McConkey, Keenan Allen, and rookie Omarion Hampton, Dissly could see enough targets to hit this mark. The Chargers’ offense frequently features tight ends, and Dissly’s 2024 career highs of 50 receptions and 481 yards over 15 games make the over a solid bet.

 

 

 

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