The Los Angeles Chargers face the Kansas City Chiefs in a thrilling Week 1 Friday Night Football clash at Arena Corinthians in Sao Paulo, Brazil, launching the 2025 NFL season.  

For Sleeper Fantasy players crafting daily fantasy lineups or entries, utilizing player projections and game insights is crucial for making informed decisions.  

Below are my top Sleeper Fantasy recommendations for the Chargers vs. Chiefs matchup, spotlighting key players to help you gain a competitive advantage in this exciting season opener.

NFL DFS Sleeper Fantasy Picks, Friday, 9/5: Fantasy Football Projections

Week 1 of the 2025 NFL season is here, and now is the best time to dive headfirst into the exciting realm of NFL DFS Sleeper Fantasy picks and fantasy football projections right now!

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Omarion Hampton Sleeper Pick: More than 12.5 Rushing Attempts 

The rookie running back of the Chargers is a good bet to have more than 12.5 rushing attempts during Week 1 against the Chiefs, as he carried the load at North Carolina last year, averaging 23.4 carries per game in 2024.

The ground-focused scheme of the Chargers with Jim Harbaugh and Greg Roman, and Najee Harris' restricted training camp with a vision injury, primes Hampton for a big role.

Despite Kansas City’s stout run defense, Hampton’s physical running style and first-round draft capital suggest he could see 13-15 carries. Many analysts ranked him as a top-20 running back, reinforcing confidence in his carry count surpassing the 12.5 threshold.

 

 

 

Drue Tranquill Sleeper Pick: More than 6.5 Tackles

In 2024, Drue Tranquill logged 94 stops (58 solo, 36 assisting) through 16 games with the Chiefs, 5.9 stops per game. He hit 7+ stops in 7 of 10 games with significant snap counts, including 10 stops (7 solo) against the Chargers, whom he played 87% of defensive snaps against.

The run-oriented system of the Jim Harbaugh-led Chargers, led by rookie RB Omarion Hampton, suits Tranquill well, given his ability on run defense, even if he garnered just a 61.6 PFF grade on the position in 2024. With his history, high percentage of snaps, and emotion on facing the team that once released him, it is a good bet that Tranquill will top 6.5 stops if he handles a high number of snaps.

 

 

 

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