Hey everyone, we're gearing up for an exciting Sunday slate in Week 12 of the 2025 NFL season on November 23, and it's packed with some killer player prop opportunities that sharp bettors won't want to miss. I've dug into the latest stats, along with the latest on lineups, injuries, and those key matchups that can make or break a bet. Here are my top six picks, focusing on guys in prime spots to deliver based on trends, volume, and defensive weaknesses. Let's break them down and cash in.

 

 

 

Best NFL Week 12 Player Prop Picks: Drake Maye Over 257.5 Passing Yards (Bonus value: Drake Maye 300+ passing yards +236)

The Patriots head to Cincinnati as rare road favorites in a game with a total climbing north of 50 at some books. Second-year QB Drake Maye has been one of the league’s breakout stories, averaging 258 yards per game on the season and 270+ in each of his last three starts. He has cleared 257.5 in six of 11 games and is coming off back-to-back 281- and 270-yard performances. Even when New England leads, Cincinnati’s middling pass defense and up-tempo offense should keep this one competitive and airy. Maye’s 8.3 YPA and improving ball security make the over extremely playable, and if you really want to get crazy with it you can take 300+ passing yards at +236. 
 

 

 

NFL Week 12 Best Player Props : Kayshon Boutte Anytime TD

Same game, other side of Maye’s passing attack. Boutte missed the last two weeks due to an injury he suffered against Atlanta in Week 9, where he exited early with zero catches after a hot streak. But his underlying profile remains strong: 24-431-5 on only 28 targets this year (18.1 YPC, 83.9% catch rate). He scored in four straight games from Weeks 2-8, including a two-TD explosion. With the Patriots favored and likely to sustain drives in his return game, Boutte’s snap share (nearly 70%) and red-zone usage make him a prime bounce-back candidate against a Bengals secondary that has surrendered the 12th-most passing TDs in the league.
 

 

 

NFL Week 12 Best Player Props: Joe Flacco Over 37.5 Pass Attempts

Flacco has turned into a volume monster since landing in Cincinnati. Over his last five starts he has averaged 42.6 attempts per game, going 45, 47, 34, 47, and 40. The Bengals rank 2nd in the NFL in pass attempts per game (37.3) and face a Patriots defense that has allowed the 8th-highest opponent pass-play rate this season. Game script should stay pass-heavy on both sides, and Flacco has cleared 37 attempts in seven of his nine games this year. Easy over.
 

 

 

NFL Week 12 Best Player Props: Jacoby Brissett Over 1.5 Passing Touchdowns

Brissett has been Mr. Consistency for Arizona: exactly two passing TDs in each of his last five starts, giving him a perfect 5-for-5 hit rate on this line over that stretch. The Cardinals lead the NFL in pass attempts per game (37.5) and Brissett is averaging 2.0 TD passes per game on the season. No matter who Arizona draws this week, the volume and red-zone efficiency keep this one of the safest TD props on the board.
 

 

 

NFL Week 12 Best Player Props: Travis Etienne Over 11.5 Rushing Attempts

Etienne remains Jacksonville’s clear workhorse, averaging 14.9 carries per game and 15.4 over his last five contests. He has cleared 11 attempts in nine of his ten games this season. The Jaguars rank 4th in rushing attempts per game (29.5) and continue to feed Etienne even in negative game scripts because of his receiving ability (59 catches). Pure volume play. Etienne has only fallen under this number once all year when he left early with an injury.
 

 

 

NFL Week 12 Best Player Props: Shedeur Sanders Over 157.5 Passing Yards

The rookie out of Colorado makes his first NFL start for Cleveland against the Raiders. His Week 11 relief appearance was ugly (4-of-16, 47 yards), but he now gets a full week of prep in an offense that ranks top-8 in pass attempts per game. The Raiders allow the 10th-most passing yards per game and have been torched by backup and rookie QBs multiple times this season. A line this low for a starting quarterback with Shedeur’s arm talent is simply too short. 
 

 

 

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