The 2025 NFL season is in full swing, and the excitement builds for an electrifying Friday Night Football matchup. Our NFL FNF player prop picks are here to guide you through the best bets for the highly anticipated Chargers vs Chiefs player props. 

When the Los Angeles Chargers face their AFC West rivals, the Kansas City Chiefs, on Friday, September 5, bettors are diving into the Chargers vs Chiefs player props to uncover value in individual performances that could shape the game’s outcome.

Whether you’re eyeing quarterback passing yards, rushing totals, or receiving targets, these insights will sharpen your strategy for a night of thrilling action.
 

 

 

Best NFL Friday Night Football Player Prop Picks; Chargers vs Chiefs Player Props: Drue Tranquill Over 6.5 Tackles+Assists

I’m pounding the over on Drue Tranquill’s 6.5 tackle prop at -129 on DraftKings. In 2024, Tranquill racked up 94 tackles (58 solo, 36 assisted) across 16 games with the Chiefs, averaging 5.9 tackles per game. 

Dig deeper, and the numbers pop: he cleared 7 tackles in 7 of 10 games with significant snap counts, including a 10-tackle (7 solo) masterclass against the Chargers while logging 87% of defensive snaps. 

The matchup is juicy. The Chargers, under Jim Harbaugh, lean hard into a run-heavy scheme with rookie RB Omarion Hampton, which plays right into Tranquill’s wheelhouse as a run-stuffing linebacker, even with a modest 61.6 PFF run defense grade in 2024. 

His track record, high snap share, and extra juice facing his old squad make this a no-brainer. If Tranquill sees his usual workload, the over 6.5 tackles is a sharp play with strong value. Lock it in.
 

 

 

Chargers vs Chiefs Player Prop Bets: Xavier Worthy Over 4.5 Rushing Yards

In 2024, the Chiefs' speedy rookie wide receiver, Worthy, showcased explosive playmaking ability, producing 6.2 yards per rush on scarce carries of the sort (12 carries, 74 yards across 16 games).

He topped 4.5 rushing yards in 6 of 8 games that he played at least one carry, frequently taking advantage of jet sweeps and end-arounds within Andy Reid's inventive offensive playbook. 

The Jim Harbaugh-led Chargers defense registered a fairly sturdy but non-impervious 4.3 yards per carry given figure for 2024, according to NFL statistics.

As Patrick Mahomes will probably attract defensive focus, Worthy's quick-hitting running chances will come to pass, given that he has 4.21-second speed on the 40-yard dash.

Unless it is a low-volume game script, Worthies' big-play ability makes the over 4.5 rushing yards a sharp bet at -110 juice, given that he receives at least one purposeful carry.
 

 

 

Friday Night Football Player Props: Quentin Johnston 1st Quarter Receiving Yards - Over 0.5 Yards +150

Johnston had 55 receptions worth 711 yards and 8 TDs in 15 games with the Chargers, including 219 yards on 18 receptions by the close of the opening quarter, which took him over 0.5 yards 12 times on the year (80% hit rate).

Yes, Keenan Allen is again with the Chargers and Johnston's target allocation will be slightly variant, but the role that he has played within Jim Harbaugh's system is unique.

Despite missing the bulk of the preseason due to a concussion, he managed to get beyond the protocol and has been practicing full this week and wasn't on Thursday's injury report. It seems that Johnston is scheduled to play on the neutral-site opener on Friday against the Chiefs in Brazil.

Johnston's playmaking skills and speed make the over 0.5 receiving yards in the first quarter at +150 a fair value play if he receives his typical number of snaps.
 

 

 

How to bet on NFL Week 1 Opening Game at BetMGM & Claim Your $1,500 Bonus with promo code ALARM

You can get started claiming your $1,500 sign-up bonus in just three steps:

  1. Use this link to create a new BetMGM account
  2. If asked, enter BetMGM promo code ALARM
  3. Make a first-time deposit of $10 or more
  4. Wager at least $10 up to $1,500 on anything

You'll then receive your winnings from your qualifying wager if it hits, or automatically be paid back in bonus bets worth the amount you wagered if it doesn’t. 

If you want to place a wager today, why wait? Join here and make that wager an insured one with BetMGM's First-Bet Offer: $1,500 Paid Back. Just remember to use BetMGM bonus code ALARM.
 

Â