As Thursday Night Football illuminates SoFi Stadium on October 2, the NFC West grudge match between the San Francisco 49ers and Los Angeles Rams delivers primetime fireworks, pitting explosive offenses against a backdrop of divisional tension. 

For PrizePicks players eyeing those lucrative over/under lines, our data-backed projections dissect player stats, matchup advantages, and prop recommendations to sharpen your entries and boost your payouts. 

From Christian McCaffrey's rushing dominance to Matthew Stafford's deep-ball threats, we've crunched the numbers for the picks that could turn your TNF slip into a big win complete with lineup-building strategies to maximize your edge.

PrizePicks NFL Picks For Thursday Night Football, 10/2: NFL DFS Projections

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Davante Adams PrizePicks NFL Pick: Over 0.5 Rush+Rec TDs

Davante Adams is the go-to anytime touchdown pick to start things off with a bang. 

The Rams' star wideout has scored in three consecutive games, dominating as a red zone beast with a 47% target share in those high-stakes situations through the season's opening month.

The 49ers boast a stout run defense, and while Kyren Williams is a touchdown-scoring machine, expect Adams to see plenty of end-zone opportunities tonight against San Francisco's pass defense.

 

Mac Jones PrizePicks NFL Pick: More Than 33.5 Pass Attempts

This one's a touch uncertain, but the game's pace screams pass-heavy night for Mac Jones. 

The 49ers roll in as road underdogs against the Rams, banged up on offense and primed to air it out just to hang around.

Jones has aired it out big in his two starts this year 39 and 41 attempts each time and tonight's go-to targets figure to be Kendrick Bourne and Demarcus Robinson, with Christian McCaffrey likely snagging near double-digit looks from the backfield to keep things balanced.

Catch the 49ers playing from behind in the second half? It'll be pass city from there, fueling that over with ease.

 

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