Welcome to Week 2 of the NFL season, where the excitement of PrizePicks NFL Picks ignites with a dynamic lineup of games! As the 2025 season progresses, our carefully selected PrizePicks NFL Week 2 picks are crafted to guide you through the betting landscape and pinpoint top-value opportunities. 

From under-the-radar road teams to undervalued home contenders, we’ve dissected matchups, player stats, and early-season trends to bring you a tailored list of PrizePicks NFL Week 2 plays ready to surpass expectations. Jump into our top recommendations and start the week with a winning edge!

PrizePicks NFL DFS Picks for Sunday NFL Week 2, 9/14: NFL DFS Projections

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CeeDee Lamb PrizePicks NFL Pick: More Than 80.5 Receiving Yards

For PrizePicks NFL Week 2 Picks, CeeDee Lamb stands out as a top player prop. In Week 1, Lamb torched a tough Eagles secondary, securing seven receptions for 110 yards, despite a few drops that could’ve easily pushed him beyond 150 yards.

 Heading into the September 14 matchup against the Giants at home, Lamb faces an ideal opportunity. The Giants’ secondary faltered in Week 1, surrendering seven catches for 77 yards to Deebo Samuel. While New York’s front seven poses a challenge, their backfield remains vulnerable. 

If Dak Prescott gets clean pockets, he’ll likely feed Lamb repeatedly, positioning him as one of the best PrizePicks NFL Week 2 plays for a massive performance.

 

Breece Hall PrizePicks NFL Pick: More Than 13.5 Rushing Attempts

For PrizePicks NFL Week 2 Picks, we're zoning in on Breece Hall as a prime play. Despite offseason talk of Braelon Allen cutting into Hall's carries, Week 1 proved otherwise, with Hall commanding 19 carries for 107 yards compared to Allen’s mere six. 

The Jets’ offense, now powered by Justin Fields at quarterback, is built to dominate on the ground. Fields’ dynamic rushing ability evidenced by his 1,143 yards in his second NFL season makes their RPO scheme a nightmare for defenses. This isn’t a knock on Lamar Jackson; Fields is simply a unique force. 

Facing a Bills defense missing key tackle Ed Oliver and still recovering from Lamar Jackson and Derrick Henry’s Week 1 onslaught, the Jets are poised to exploit their run game. Look for Hall to lead the charge, making him a top PrizePicks NFL Week 2 play.

 

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