As the NFL season ramps up, Week 3 launches with an electric AFC East rivalry on Thursday Night Football: the Miami Dolphins facing off against the Buffalo Bills in a clash of explosive offenses illuminated under the primetime lights. 

With Josh Allen and the Bills aiming to keep their perfect record intact, Tua Tagovailoa and the Dolphins are geared up to spring the upset. This high-stakes showdown is primed for fireworks, offering sharp bettors a goldmine of chances to hit big on PrizePicks NFL picks. 

Jump into our expert TNF Week 3 picks for PrizePicks Fantasy Pick'em, where we dissect the prime higher and lower plays to craft your unbeatable lineup and crush the competition.

PrizePicks NFL Picks for Thursday Night Football, 9/18: NFL PrizePicks Projections

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James Cook PrizePicks Promo NFL Pick: More Than 0.5 Rushing/Receiving TD

James Cook is straight-up a touchdown magnet, already punching in three scores across the first two weeks of the NFL season. Sure, there's always the lurking chance of Josh Allen bulldozing in for a one-yard plunge, but the Bills are rolling with full confidence in handing the ball to Cook deep in the red zone right now.

 He exploded onto the scene in 2024, racking up 16 rushing touchdowns and two receiving ones, while lighting up the scoreboard in 12 of his 16 games last year. As heavy home favorites tonight, the Bills' offense should feast—making Cook a no-brainer to cash the over on his anytime touchdown prop in our PrizePicks NFL picks.

 

 

 

Tua Tagovailoa PrizePicks NFL Pick: More Than 2.5 Sacks Taken

Tua Tagovailoa's been under siege, eating eight sacks across the Dolphins' first two games this season—including a brutal five-sack beatdown from the Patriots' front last week in their defeat. Now, on a punishing short week, they're rolling into hostile Buffalo territory with their offensive line still leaking like a sieve. 

Sure, Mike McDaniel's a wizard at scheming up plays, but this Bills defense is no joke, boasting disruptive pass rushers like Joey Bosa who can wreak absolute chaos in the pocket if Miami's receivers hit a snag getting separation, leaving Tua to dance and dodge a bit too long. That's why we're eyeing the over on Tua's sack prop as a sharp angle in our TNF Week 3 picks for PrizePicks NFL picks.

 

 

 

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