The Los Angeles Chargers and Kansas City Chiefs kick off Week 1 of the 2025 NFL season with a Friday Night Football showdown in Sao Paulo, Brazil, at Arena Corinthians. 

For PrizePicks users looking to build daily fantasy lineups or place entries, player projections and game stats are key to making informed decisions. 

Below are my PrizePicks plays for the Chargers vs. Chiefs game, highlighting top player picks, including sleeper quarterbacks, explosive running backs, and under-the-radar wide receivers to give you an edge in this high-stakes opener.

PrizePicks NFL DFS Picks for Friday Night Football, 9/5: NFL DFS Projections

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Justin Herbert PrizePicks NFL Pick: More Than 0.5 Passing TDs

Capitalizing on the “Goblin” projection for Justin Herbert, with his passing touchdown total set at only 0.5 in the matchup against the Kansas City Chiefs.

Despite throwing 23 touchdown passes last season, Herbert managed to throw touchdowns in both games against the Chiefs and in all but three games overall last year. 

Expect Herbert to push the ball downfield, even if the Chargers' offense faces challenges.

 

 

 

Drue Tranquill PrizePicks NFL Pick: More Than 7.0 Tackles+Assists

In 2024, Tranquill registered 94 tackles (58 solo, 36 assist) in 16 games with the Chiefs, who averaged 5.9 tackles per game but hit 7+ tackles in 7 of 10 games with significant snap counts, including a 10-tackle game (7 solo) against the Chargers on 87% defensive snaps.

The running-friendly scheme of the Chargers under Jim Harbaugh, led by rookie RB Omarion Hampton, also matches well with Tranquill's forte on running defense, notwithstanding a 61.6 PFF running defense grade for the year 2024.

Because of his history, high snap percentage, and desire against his regular team, the over 7.0 tackles+assists is a worthy bet if he sees high snaps.

 

 

 

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