The entire 2026-27 NFL season kicks off with not only a Super Bowl rematch, but also a matchup before the usual Thursday Night Football game. Whether you’re pulling for Drake Maye and the New England Patriots to get their revenge or Sam Darnold and the Seattle Seahawks to pour salt in the wound, we’re here to help you enjoy the game to the fullest. That’s why we’ve hooked you up with our best Patriots vs. Seahawks predictions for Wednesday Night Football!

We’ve also hooked you up with more than just a best bet from our Patriots vs. Seahawks picks - you’ll also find a GUARANTEED DraftKings Sportsbook promo code bonus as well!

🔥 Patriots vs. Seahawks Predictions for Wednesday Night Football, NFL Week 1

Nearly exactly seven months to the day. That’s how long it’s been since we saw meaningful football other than games that could just make you upset about having a fantasy draft too early by seeing one of your guys get injured. There’s no better way for a new season to start than with a Super Bowl rematch, which means more Patriots vs. Seahawks predictions!

Those who made them on Seattle back in February came out on top, but there have been significant changes on both sides since then. Of course, we’re referring to the lack of Kenneth Walker for the champs and the addition of AJ Brown for the runners-up. Despite those factors, we still see the Patriots vs. Seahawks odds quite significantly favoring JSN and company.

Of course, now that the preseason is in the books, we get to enjoy countless player props along with game markets. While you’ll find that is our preferred approach a vast majority of the time, until we see this first week of action, we’ll be taking overall game markets more than future slates. With that in mind, let’s break down the best bet from our Patriots vs. Seahawks predictions for WNF!

🏅 Patriots vs. Seahawks Expert Pick: Under 44.5 Points (-115 at DraftKings)

Super Bowl LX saw a pick-6 from Uchenna Nwosu, a TD reception by AJ Barner, and STILL stayed under this total. We aren’t going to bank on those things happening again, and oh yeah, all the excitement came in the fourth quarter. Many fans likely don’t remember that watching Patriots vs. Seahawks predictions play out was borderline boring for a while.

The only scoring we saw the entire first half was three Jason Myers field goals. After tacking on more in the third, it was a 12-0 game heading into the fourth quarter. Not only that, but the final 17 points that were scored came in the final 17 minutes of the game. So, we are expecting to see what led these teams to the big game for fans to make Patriots vs. Seahawks picks - defense.

Sure, Seattle has arguably the best WR in the game with Jaxon Smith-Njigba, but the Mike Vrabel squad held JSN to just four catches for 27 yards. We aren’t saying that he’ll get THAT shut down again, but this won’t be like facing the Dallas Cowboys' pass defense (yes, we like the Caleb Downs draft pick). Do we also need to remind fans that no Patriots vs. Seahawks predictions will be made on the reigning Super Bowl MVP?

Kenneth Walker now with the Kansas City Chiefs and Zach Charbonnet still rehabbing means that the backfield responsibility falls on the shoulders of Jadarian Prince. Admittedly, we're fans of the final first-round draft pick, but this NE defense was among the top defenses taken in fantasy football drafts for a reason.

Of course, the same can be said for Seattle, which is why we also aren’t letting the AJ Brown addition for the Pats keep us off this pick. These teams already had a pseudo-rematch to close out the preseason in a 9-9 tie, and while we aren't calling for just 18 points, we are locking in the best bet from our Patriots vs. Seahawks predictions on under 44.5 points (-115 at DraftKings).

 

 

 

👀 How To Watch Patriots vs. Seahawks NFL Week 1 Wednesday Night Football

Again, this season opener takes place even earlier in the week than the league has already taken over, so be sure to check out how to watch Patriots vs. Seahawks NFL Week 1 Wednesday Night Football below:

  • Where: Lumen Field in Seattle, WA
  • When: 8:20 PM ET on 9/9
  • Watch on TV: NBC
  • Where to stream: Peacock

🔢 Patriots vs. Seahawks Odds, Spreads, Total & Betting Lines

You’ve already seen our best bet, but if you want more skin in the very first game of the season, here are the latest Patriots vs. Seahawks odds for Wednesday at DraftKings Sportsbook:

 

 

 

🏉 Patriots vs. Seahawks Injury Report & Latest News

It wouldn't be a season opener without Patriots vs. Seahawks news to monitor, and right now (especially for our best bet), it's all about New England hoping that the Christian Gonzalez contract dispute doesn't become an issue. As for an actual injury standpoint, the #1 name to monitor for the road team is undoubtedly TreVeyon Henderson, who didn't practice yesterday (Sunday).

As for Patriots vs. Seahawks news and injuries in Seattle, they have a few guys with questionable tags, but none that are major concerning. Of them all, the one to keep tabs on is Nick Emmanwori. Of course, we'll also remind fans that Zach Charbonnet is still recovering from his knee injury and is starting the season on the PUP list. 

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