A lot has changed since 2012 (and 2008), but the NFL Week 13 slate in 2025 closes out with a Super Bowl rematch with the New York Giants taking on the New England Patriots. Whether Tom Brady is your G.O.A.T. and you’re rooting for revenge or you’re wishing for an Eli Manning return, we’ve got our best Giants vs. Patriots predictions for MNF.

Even if you just want to reminisce rather than use our Giants vs. Patriots picks, we’ve also hooked you up with a guaranteed 10x Novig Sportsbook promo code bonus! 

Giants vs. Patriots Predictions for Monday Night Football, NFL Week 13

First and foremost, the Giants vs. Patriots odds suggest that rookie Jaxson Dart will be back to take Eli Manning’s old spot after missing the past two games due to a concussion. That’s to say that we’ve had Jaxson Dart player prop lines since as early as Tuesday morning, although Jameis Winston makes every game more exciting.

Now facing a Patriots defense that has been remarkable against the run, perhaps Jaxson Dart will end up being the focus of plenty of Giants vs. Patriots predictions for MNF. Speaking of defense, we learned rather early on Monday morning that New York had fired their defensive coordinator.

That doesn’t surprise me in the least. The Giants' run defense is just as bad as the Pats is great; they rank dead last in defensive EPA per rush, which has helped us cash a few of our NFL best bets this year. Of course, it’s our job to keep those rolling with a best bet from our Giants vs. Patriots predictions this week.

Before we get into our top pick here, we’d be remiss not to also share our premium NFL best bets for Monday Night Football here!
 

 

 

Giants vs. Patriots Best Bet: TreVeyon Henderson Over 63.5 Rushing Yards (-116 at Novig)

Just as everyone expected after a 4-13 season, the Patriots were the first and are currently the only team with 10 wins this year. With the Los Angeles Rams at 9-2 in the NFC, perhaps we highlighted the wrong Super Bowl rematches at the start, and we’ll see a rematch of Super Bowl LIII instead.

Ok, before a new tangent starts - Giants vs. Patriots predictions for MNF Week 13 in 2025. These teams met somewhat recently during Thanksgiving Week of 2023, but that was with Mac Jones and Tommy DeVito under center. With that in mind, it shouldn’t come as a surprise that a whopping 17 total points were scored across both teams.

It was a 10-7 victory for the G-Men, but we fully anticipate a New England victory at home this time around. New York put up such a massive fight against the Detroit Lions last weekend, only to lose in overtime, so it’s going to be so difficult for them to recover from that. The Malik Nabers' disgruntled tweet doesn’t help the team’s mentality either.

It will be interesting to see how their defensive philosophy changes (if it all) with a new defensive coordinator, but we still love our Giants vs. Patriots predictions on the NE run game. The fact remains that the Giants just don’t have the Jimmies and the Joes to match any new X’s and O’s they may get. 

We’d certainly prefer a healthy Will Campbell, but New York also has guys on defense banged up like Kayvon Thibodeaux. New England should also have a lead in this game, which means grinding out the clock on the ground. Therefore, the best bet from our Giants vs. Patriots predictions is TreVeyon Henderson over 63.5 rushing yards (-116 at Novig).
 

 

 

How To Watch NFL Week 13 Monday Night Football

As always when it comes to MNF, it’s the standalone matchup, and here’s how to watch Giants vs. Patriots NFL Week 13 Monday Night Football:

  • Where: Gillette Stadium, Foxborough, MA
  • When: 8:15 PM ET on 12/1
  • Watch on TV: ESPN, ABC
  • Where to stream: ESPN+

 

 

 

Giants vs. Patriots Odds, Spreads, Total & Betting Lines

Like the previous Super Bowls between these teams, New England is favored, and here are the latest Giants vs. Patriots odds for MNF at Novig Sportsbook:

 

 

Giants vs. Patriots Injury Report & Latest News

As it has been for a few straight weeks now, the biggest Giants vs. Patriots injury news to monitor in New York (New Jersey) is Jaxson Dart. Again, he is expected to be back to try and will this team to victory without Malik Nabers and Cam Skattebo. They also have a few defensive concerns, headlined by Kayvon Thibodeaux.

As for Giants vs. Patriots injury updates in New England, we saw the return of Rhamondre Stevenson last weekend. However, Will Campbell went down this past Sunday, who is a fantastic young left tackle. Keep track of all of those guys and much more with the Fantasy Alarm NFL injury report.
 

 

 

How To Make Giants vs. Patriots Picks At Novig Sportsbook & Claim Your $50 Bonus w/ Code ALARM

We know that fans in NY/NJ and MA likely have some sportsbooks under their belt, but Novig is a peer-to-peer sportsbook for commission-free lines! Along with it being legal in over 40 states, make sure that you add to our best Giants vs. Patriots predictions for MNF with a guaranteed 10x Novig promo code bonus:

  1. Click here to create a new Novig account
  2. Enter our Novig MNF promo code ALARM
  3. Spend $5 or more on anything at the Coin Store
  4. Receive a $50 bonus GUARANTEED

At the Coin Store, you’ll purchase Novig Coins/Cash to properly use the platform, which you can use for anything, not just our Giants vs. Patriots picks for MNF. Whatever is on your radar, make it more valuable by creating a new account using our exclusive Novig MNF promo code ALARM!
 

Â