The Los Angeles Chargers take on the Kansas City Chiefs in an electrifying Week 1 Friday Night Football matchup at Arena Corinthians in Sao Paulo, Brazil, kicking off the 2025 NFL season.

For Drafters Fantasy Pick'em players building daily fantasy lineups or entries, leveraging player projections and game insights is essential for making smart choices. 

Below are my top Drafters Fantasy Pick'em recommendations for the Chargers vs. Chiefs game, highlighting key players to give you a competitive edge in this high-profile season opener.

Drafters NFL DFS Picks for Friday Night Football, 9/5: NFL DFS Projections

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Will Dissly Drafters NFL Pick: Over 16.5 Receiving Yards

The Chiefs' defense struggled significantly against tight ends last season, allowing a league-high 942 receiving yards and the second-most receptions (80) to the position. 

This vulnerability makes Dissly a strong candidate to exceed this relatively low yardage threshold.

In 2024, Dissly recorded 481 receiving yards on 64 targets across 17 games, averaging 28.3 yards per game. He surpassed 16.5 receiving yards in 11 of those games.

 

 

 

Hollywood Brown Drafters NFL Pick: More Than 18.5 Yards Longest Reception

Brown’s speed (4.27-second 40-yard dash) and deep-threat ability align perfectly with Patrick Mahomes’ big-play passing style. 

In 2024, Brown averaged 12.8 yards per catch with the Chiefs, with 5 of his 14 games featuring a reception of 19+ yards, despite missing time due to injury.

The Chargers’ secondary, while improved, struggled against explosive plays last season, giving up 30 receptions of 20+ yards. With Rashee Rice suspended and Xavier Worthy drawing coverage, Brown could exploit single-coverage for a big gain. 
 

 

 

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