Baseball is finally back. The 2026 MLB season gets underway on Wednesday, March 25, with the New York Yankees traveling to Oracle Park to take on the San Francisco Giants in MLB Opening Night, streaming exclusively on Netflix. It is the only game on the entire schedule, which means every DFS dollar is concentrated into one matchup. Max Fried takes the ball for New York in his first Opening Day start as a Yankee, going head-to-head with Logan Webb, who makes his fifth consecutive Opening Day start for the Giants. With a 6.5 over/under, a pitcher-friendly ballpark, 15 mph winds rolling in off McCovey Cove, and a 63-degree first pitch, this slate sets up as a low-scoring, pitching-dominated affair. 

Before you lock your lineups, make sure you check out the Fantasy Alarm MLB DFS Pitcher Projections and MLB DFS Hitter Projections for the full picture on tonight's numbers, and run your builds through the MLB DFS Lineup Optimizer to make sure you are getting the most out of every dollar. Here is everything you need to build winning lineups.

 

Yankees vs. Giants Opening Night Odds

New York Yankees vs. San Francisco Giants

  • NYY: -120 ML
  • SF: +100 ML
  • Total: 6.5 O/U

Yankees vs. Giants: Pitching Matchup

Max Fried, New York Yankees

Max Fried takes the ball for New York in what feels like a long-overdue Opening Day moment. Gerrit Cole is out following Tommy John surgery, Carlos Rodon continues his rehab assignment, and Clarke Schmidt is also sidelined, leaving Fried as the clear and unquestioned ace of this staff. He earned that designation in 2025, posting a 3.25 ERA and 4.8 WAR across 185 innings in his first season as a Yankee and finishing fourth in the American League Cy Young voting. His command-oriented left-handed approach generates weak contact and soft grounders, a profile that matches up reasonably well against a Giants lineup that leans contact-first. The one consideration pitching at Oracle Park is the cold, heavy air at night. Those conditions historically suppress scoring and reward pitchers who work down in the zone, which Fried does naturally. He is priced at $16,500 CPT and $11,000 UTIL on DraftKings.

Logan Webb, San Francisco Giants

Logan Webb is the best play on this entire slate and it is not particularly close. The 29-year-old right-hander enters his fifth consecutive Opening Day start having posted a 3.22 ERA, 1.24 WHIP, and a career-high 224 strikeouts across 207 innings in 2025, leading the National League in innings for the third straight season. He also made two starts for Team USA in the World Baseball Classic, combining for 11 strikeouts in 8.2 innings before returning to the Giants. At Oracle Park specifically, Webb was even better last season, going 8-4 with a 3.10 ERA in 19 home starts. His pitch mix of sinker (34%), sweeper (27%), and changeup (24%) is a groundball machine that plays perfectly at this venue, where the 25-foot right field wall eats up line drives and the night wind keeps everything in the park. He is the anchor of every viable lineup on this slate and is priced at $16,800 CPT and $11,200 UTIL on DraftKings.

 

Yankees vs. Giants: Projected Lineups

New York Yankees Projected Lineup

  1. Trent Grisham, CF
  2. Aaron Judge, RF
  3. Cody Bellinger, LF
  4. Ben Rice, 1B
  5. Giancarlo Stanton, DH
  6. Jazz Chisholm, 2B
  7. Ryan McMahon, 3B
  8. Jose Caballero, SS
  9. Austin Wells, C

San Francisco Giants Projected Lineup

  1. Heliot Ramos, LF
  2. Rafael Devers, 1B
  3. Matt Chapman, 3B
  4. Willy Adames, SS
  5. Luis Arraez, 2B
  6. Jerar Encarnacion, DH
  7. Jung Hoo Lee, RF
  8. Harrison Bader, CF
  9. Patrick Bailey, C
 

Opening Night Preview: Key Players to Watch

Aaron Judge, OF (Yankees)

Judge remains the premier power threat on this slate. The Northern California native returns to Oracle Park - where he grew up a Giants fan - to face Logan Webb in what is easily the marquee individual matchup of the night. In a showdown context where the goal is to find the bats that can break through a pitcher's duel, Judge carries a higher ceiling than anyone else in either lineup. He is a viable CPT option on DraftKings at $15,000, providing the anchor for any Yankees-heavy build. On FanDuel, he is the unquestioned top MVP play at $22,500.

DraftKings CPT: $15,000 | DraftKings UTIL: $10,000 | FanDuel MVP: $22,500 | FanDuel UTIL: $15,000

Rafael Devers, 1B/3B (Giants)

Devers is the cornerstone of any Giants stack. While the trade that brought him from Boston last June was the talk of the 2025 season - he’s now fully entrenched as the cleanup presence San Francisco lacked for years. Note that Devers is a left-handed bat facing the Yankees' southpaw ace, Max Fried. While the same-side split isn't ideal, Devers has the raw power to drive the ball out of Oracle Park in any conditions. He is a core UTIL piece on DraftKings and a legitimate MVP pivot on FanDuel, where his $19,500 salary allows you to build a premium supporting cast around him.

DraftKings UTIL: $9,600 | FanDuel MVP: $19,500 | FanDuel UTIL: $13,000

Jazz Chisholm, 2B (Yankees)

Chisholm is the ideal pairing with Judge in GPP builds. His power-speed profile gives him a fantasy ceiling that few in this game can match. Batting near the top of the order as a left-handed bat, he’ll face the right-handed Webb, giving him a volume and matchup advantage in a game where runs are expected to be at a premium. On FanDuel, he sits at a fair $11,800 UTIL price for a player with 30/30 potential.

DraftKings UTIL: $9,000 | FanDuel UTIL: $11,800

Willy Adames, SS (Giants)

Now entering his second season in San Francisco after his massive free-agent deal prior to 2025, Adames has become a veteran leader in this clubhouse. He typically bats near the top of the order and, as a right-handed bat, he gets a genuine matchup edge against Max Fried tonight. At $8,000 on DraftKings, he’s a strong tournament play who could be overlooked in favor of Devers or the pitching staff.

DraftKings UTIL: $8,000 | FanDuel UTIL: $10,200

Trent Grisham, OF (Yankees)

Grisham offers one of the best value-to-point ratios on the slate. As a left-handed contact bat with solid gap power, he should see plenty of volume in the Yankees' outfield. On FanDuel, he’s a contrarian MVP flyer at $11,400, saving you massive salary compared to Judge while allowing you to stack the mid-tier of both lineups.

DraftKings UTIL: $6,400 | FanDuel MVP: $11,400 | FanDuel UTIL: $7,600

Matt Chapman, 3B (Giants)

Chapman remains a steady, reliable option in the Giants' infield. Like Adames, his right-handedness gives him an advantage against Fried. In a game projected for low scoring, Chapman’s consistent contact and defensive stability (which keeps him on the field for all nine innings) make him a safe floor play for cash games.

DraftKings UTIL: $7,400 | FanDuel UTIL: $9,000

Jose Caballero, SS (Yankees)

With Anthony Volpe confirmed out due to a shoulder injury, Caballero steps into the starting shortstop role. He’s a "near-lock" value play at $5,400 on DraftKings, inheriting the DFS value of a starting role in a high-profile matchup - use the savings here to pay up for the Webb/Fried pitching tandem.

DraftKings UTIL: $5,400 | FanDuel UTIL: $5,200

Other Notable Options

Heliot Ramos, OF (Giants): A right-handed power bat who matches up well against Fried at home. DraftKings UTIL: $7,000 | FanDuel UTIL: $8,200

Cody Bellinger, OF (Yankees): The left-handed hitting Bellinger provides a high floor. After re-signing with the Yankees this past January - he’s looked sharp in spring training and is a reliable mid-tier anchor. DraftKings UTIL: $8,600 | FanDuel UTIL: $9,600

Giancarlo Stanton, DH (Yankees): Massive home run upside, but heavily suppressed by the Oracle Park conditions and the 24-foot right-center wall. DraftKings UTIL: $8,200 | FanDuel UTIL: $10,800

Harrison Bader, OF (Giants): Currently Day-to-Day (hamstring) - if ruled out, Luis Matos becomes a top-tier value substitute at $4,200 (DK) / $3,400 (FD).

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