MLB Home Run Picks Today: Best Home Run Predictions for June 5th, 2026
Fifteen games on a Friday, and our best MLB home run picks for today have plenty of angles to work through. Brady Singer drawing the Cardinals in St. Louis stands out immediately for our MLB home run predictions - Busch Stadium plays big, and the matchup is worth targeting from both sides. Brandon Sproat in Colorado earns a closer look too, with Coors Field doing what Coors Field always does for MLB home run predictions.
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⚾ Top MLB Home Run Picks for Today
Friday's full 15-game slate sharpens the search for our best MLB home run picks for today, but our MLB expert picks go deeper into the matchups. Sticking with the longball, here are the three names leading our top MLB home run predictions for 6/5:
🔥 Best Matchups for Home Runs Today, 6/6: Ballpark Factors & Weather Impact
Our MLB weather report is essential on a full Friday card spread coast to coast. Brady Singer in STL and Ryan Feltner in Colorado are among the arms worth flagging for HR/FB tendencies alongside the headliners. We’ll be checking out even more, like hard-hit and barrel rates; here is how our three featured best MLB home run picks for today break down:
Shohei Ohtani (+282)
We’re going to lead off with the big, popular, chalk name on the board today, but it’s also the final game on our Friday night. The battle of LA means a “revenge” game for Shohei Ohtani with Angels vs. Dodgers, even though it’s been long enough that it doesn’t give that vibe. Regardless, we’re rolling with the generational talent to start our MLB home run picks.
He can absolutely start a new streak for us, and he speaks for himself at this point. That’s good news, as the Angels are still TBD with their starting situation. If it’s Reid Detmers- great; Ohtani is awesome lefty vs. lefty. If it’s an opener/bullpen day for them - great, the Angels bullpen is absolutely terrible with the second-highest ERA and 32 homers allowed.
It’s not going to be our biggest payout of the day, but let’s enjoy some Friday night fireworks in LA by starting our best MLB home run picks for today with Shohei Ohtani to hit a HR (+282 at DraftKings) after a day off.
JJ Bleday (+485)
Dodger Stadium is one of the best overall targets on the board to begin the weekend, and with Roki Sasaki starting for the home team, you could also consider Mike Trout if you want a HR SGP. However, we’ll swap to targeting another pitcher with a high HR/FB ratio, which is Kyle Leahy. He’s helped us cash MLB home run picks, as has the Reds lineup.
While the game isn’t at the Great American Ball Park, we’re still going to have multiple targets at Busch Stadium tonight. We’ve got double-digit winds blowing out with hitters, starters AND bad bullpens that are the perfect trifecta. Leahy struggles against lefties, so why not go with JJ Bleday, who has cashed for us multiple times?
That includes our recent streak, as he homered THREE times in a four-game stretch! With another good matchup, we’re adding JJ Bleday to hit a HR (+485 at FanDuel) to our best MLB home run picks for today.
Alec Burleson (+500)
As much as we would love to head to Coors Field for you, we simply can’t stay away from the trifecta noted above. The other starter in this matchup is Brady Singer for the Reds, who has the absolute highest HR/FB ratio of 23.5% and 2.82 HR/9, so it’s time to target the Cardinals lineup to continue our top MLB home run picks.
Jordan Walker is the other name to consider here, but since we’ve got a theme with things already, let’s roll with another lefty. Singer has allowed a ridiculous .637 slugging to southpaws this season, including 10 homers. He might not be known as quite as powerful as Walker, but it’s more than enough vs. Singer’s fourth-highest average exit velocity.
Expect plenty of production at St. Louis tonight, as we add to our best MLB home run picks for today with Alec Burleson to hit a HR (+500 at BetMGM).
🚀 Longshot Home Run Picks Today
So many games to break down means at least one price somewhere on the board that the market has mispriced. Here is where our MLB home run predictions are pointing for the big-price target:
Ok, we’ve finally made our way to Coors Field. We don’t often get longshot-type odds given the HR-friendly environment, but we see it with Freeman. He’s “just” a contact hitter, but in Denver, that’s all it takes! He’s hit three homers on the road, so let’s get another one where conditions are even easier to help us cash another MLB longshot home run pick!
💲 Today’s Best MLB Home Run Parlay
A full Friday card, Coors Field in the evening mix, and NBA Finals Game 2 waiting at 8:30 PM ET. Lock in the best MLB home run parlay before the first pitch and let the dingers land before tip-off:
Get the MLB home run picks cashed early and settle in for Knicks vs. Spurs tonight. That is a Friday worth having.
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