Friday brings one of the deepest slates of the week, and our best MLB home run picks for today have plenty to choose from. Big starters like Gerrit Cole & Jacob deGrom are on the mound, but there are also several hitter-friendly environments. There is always long ball potential from first pitch through the West Coast nightcap, and our best MLB home run predictions for today are built around the matchups where pitcher vulnerability and park factors line up perfectly.

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⚾ Top MLB Home Run Picks for Today

Friday's full slate gives us a wide field to hunt through for our best MLB home run picks for today. Of course, you’ll still want to make the most of our MLB expert picks for additional markets. As for the always exciting dingers, here are the three names leading our top MLB home run picks for today:

 

 

🔥 Best Matchups for Home Runs Today, 5/22: Ballpark Factors & Weather Impact

Friday evening games across the Eastern and Central time zones can see conditions shift significantly between afternoon and first pitch, so our MLB weather report is essential reading before locking in any MLB home run picks today. The pitching slate has Miles Mikolas in Atlanta, Chris Paddack in Cincinnati, and Michael Soroka at Chase Field as names worth targeting from a HR/FB rate perspective. Here's how our three featured picks break down:

Max Muncy (+343)

The Great American Ball Park! It’s one of our favorite spots to turn to when it comes to the long ball, right alongside Coors Field and the home of the Sacramento River Cats. We say that so that you know that Cardinals vs. Reds could be a target for your MLB home run picks, but we’re avoiding it simply due to the weather.

With a 90% chance of rain, we don’t want to give you an option that doesn’t even happen. So, let’s start at American Family Field. That means Dodgers vs. Brewers, which also means a star-studded LA lineup to consider. Milwaukee starter Logan Henderson is making a name for himself, but he’s also helped hit MLB home run picks in back-to-back starts.

He can accumulate K’s, but he also allows a high barrel rate and is the complete opposite of a ground-ball pitcher. This LA lefty has 9 of his 12 homers vs. righties this year, so let’s kick off our best MLB home run picks for today with Max Muncy to hit a HR (+343 at Novig).

Matt Olson (+290)

Alongside the stadiums that we rattled off above, another favorite target of ours is Miles Mikolas. He’s helped us cash some YRFI picks and better props, and now it’s time to cash in even bigger. His HR/FB ratio is the absolute worst in baseball, and now he has to deal with the Atlanta Braves lineup - ideal for MLB home run picks!

The only issue here is picking your poison. We saw Michael Harris go yard twice last night en route to back-to-back games scoring 9 runs, and now we have another superstar name leading the way. Despite the high-scoring team total, Olson had a rare off-night. Thankfully, he can easily bounce back vs. Mikolas tonight.

Even if he doesn’t, the Washington bullpen is tied for the league-most 35 homers allowed! So, it’s no shock that we’re adding to our best MLB home run picks for today with Matt Olson to hit a HR (+290 at FanDuel).

Julio Rodríguez (+415)

A game that may be on a ton of fans’ radars is Mariners vs. Royals. Firstly, the game is not in Seattle, and the weather is looking great in KC - low-70’s with a light breeze tonight. If you’ve been tailing us, then you also know that Julio has cashed for us in the recent past. Believe it or not, with the odds that you see for our MLB home run picks, he’s also the #1 favorite to hit a dinger tonight!

That suggests that we won’t see a ton here tonight, but we feel otherwise against KC starter Noah Cameron. The lefty doesn’t have a ton to get excited about other than perhaps his walk rate. Ok - that means he throws inside the zone. We’ll gladly take more pitches to hit; so, let’s keep adding to our best MLB home run picks for today with Julio Rodriguez to hit a HR (+415 at BetMGM).

🚀 Longshot Home Run Picks Today

Friday nights are made for swinging for the fences on a longshot and this particular slate gives us exactly the kind of environment to do it in:

We cashed our best MLB home run longshot pick at +100 last night in LA with Athletics vs. Angels, and now we’re sticking with the aforementioned matchup in KC. The Royals lineup gets Logan Gilbert, who also likes to keep the ball in the zone. 

Garcia may not be known for raw power, but he’s an all-around great guy at the plate who gives himself enough opportunities for contact for us to make him our best MLB home run longshot pick for today.
 

 

 

💲 Today’s Best MLB Home Run Parlay

Stack our featured targets or mix in a fresh name (or two or three) from Friday's deep card alongside one of our best MLB home run picks for today:

So, what’re you waiting for? Whether you use just one of our top MLB home run picks today or mix and match to create a monster (for-fun) parlay, it’s time to capitalize!