The 2026 MLB season rolls with another full slate of games. Let’s dive into the MLB Best Bets Today for Saturday, April 25th. We have all-day baseball on tap and plenty of ways to go for our MLB picks. Enjoy these MLB predictions as you lock in your own bets ahead of today’s games. Note that all odds and betting lines are accurate as of this writing, but are always subject to change. 

MLB Picks, Predictions & Best Bets Today, 4/25

Our MLB best bets today begin with an interleague matchup between the Washington Nationals and Chicago White Sox. Plus, our MLB picks feature Jack Flaherty and the Detroit Tigers taking on the Cincinnati Reds. Check out even more MLB predictions below, including some player props and other game picks. Good luck! 

 

 

 

Nationals vs. White Sox Prediction: Saturday, April 25th

The Washington Nationals and Chicago White Sox have both played in a ton of high-scoring games this season. The Nats are averaging 5.5 runs per game on offense (third in MLB), while their pitching staff has allowed the most runs in the league thus far. Washington is also 18-8 to the over. Meanwhile, the White Sox are 16-7 to the over with the fourth-most runs allowed. 

Let’s bank on Saturday’s meeting between Chicago and Washington featuring plenty of runs on both sides. These teams played to a 5-4 final in yesterday’s series opener, but the game went under by half a run. Tonight’s pitching matchup and offensive splits point to a higher-scoring contest with the over in play. 

Nationals starter Jake Irvin has a rough 6.00 ERA through 5 starts so far. His 5.60 xERA and 4.98 FIP aren’t much better either. The right-hander has been one of the more fadeable pitchers in recent years, and 2026 is no different. His 14.9% barrel rate allowed (ninth MLB percentile), 52.2% hard-hit rate allowed (sixth), and 25.0% chase rate (19th) are all worrisome metrics. 

Irvin will now take on a White Sox lineup that’s hammering right-handed pitching lately. Over the past week, they have a league-high .399 wOBA and 154 wRC+ vs. righties. Chicago also boasts a top-10 offense in the split over the past two weeks (.352 wOBA, 122 wRC+). It’s a tough matchup for Irvin, who has a 5.48 FIP in three road starts this year after posting a 5.99 ERA on the road in 2025. 

Meanwhile, Noah Schultz could run into trouble for Chicago. The rookie southpaw has had mixed results in his first two starts this year. He tossed five solid innings against the Athletics last time out. Before that, though, he gave up four runs with four walks issued to the Rays. 

Schultz will have to deal with a Nationals offense that’s been among the league’s best against left-handed pitching. They have a .354 wOBA and 123 wRC+ vs. lefties this season (both fourth in MLB). The Nats also have a top-10 offense on the road (.334 wOBA, .268 BA, 109 wRC+). 

 

 

 

Tigers vs. Reds Prediction: Saturday, April 25th

The Detroit Tigers and Cincinnati Reds have both been playing well lately. The Tigers are 10-4 over their last 14 games, while the Reds are 8-2 over their past 10 contests. In last night’s series opener, Cincy got the walk-off victory. Let’s back Detroit to even things up on Saturday. 

Tigers starter Jack Flaherty has a decent 3.47 ERA over his first 5 starts. His 1.59 WHIP and 4.61 FIP aren’t exactly ideal, but the veteran has still been able to limit the damage. Flaherty has given up only two earned runs over his last three starts combined. The right-hander has a good opportunity to keep that up in today’s outing. 

Cincinnati’s offense is among the league’s worst against right-handed pitching this season. In the split, the Reds have just a .287 wOBA (28th in MLB) and 73 wRC+ (29th). They’re also batting a league-low .207 vs. righties so far. Those struggles have been evident over the past week as well, as Cincy’s lineup has a .282 wOBA and 70 wRC+ when facing right-handers. 

On the other side, the Detroit hitters can provide some run support in their own matchup. Reds starter Brady Singer owns a shaky 5.32 ERA and 1.65 WHIP over five starts this season. His 5.19 xERA and 4.59 FIP don’t offer much confidence either. The righty has had some decent outings, but he’s usually worth fading. 

Singer will take on a Tigers offense that’s been tough on right-handers. They have a .329 wOBA (12th in MLB) and 107 wRC+ (10th) vs. righties this year. Detroit also boasts a top-five lineup in the split over the past two weeks with a .362 wOBA (3rd), 129 wRC+ (4th), and .292 batting average (1st). This won’t be easy for Singer. 

 

 

 

Best MLB Player Prop Bets & Other Picks Today, 4/25