The Saturday College football Week 10 slate of games presents a ton of top matchups and players to target for our weekly picks. Check out some of these CFB PrizePicks top plays and college football picks as you enjoy all the action for Saturday's Week 10 slate. Alabama Crimson Tide RB Jahmyr Gibbs headlines out top player props for college football this week. If you're building CFB DFS lineups or making college football betting picks, mix in some of these player props to get full exposure. Be sure to check out our college football weekly projections to fine tune those CFB bets and props. Plus, don't forget to use the CFB DFS Playbook while entering college football daily fantasy lineups. Let's dive in and look at my top CFB PrizePicks plays and picks for college football Week 10 on November 5th.


College Football PrizePicks CFB Top Picks Week 10 Saturday

Jahmyr Gibbs, Alabama RB – OVER 99.5 Rush Yards

Yes, Gibbs has only run for 100+ yards in three of eight games this season. Plus, he’s coming off a 37-yard effort last time out. Still, we should back the Alabama lead back to eclipse the century mark in this matchup and game flow likely in his favor. Gibbs will face an LSU defense that’s giving up 153.2 rushing yards per game and 4.45 yards per carry during SEC play. The Tigers have allowed a 100-yard rusher in three straight games, including the lead backs for the two best offenses they’ve faced this season. Tennessee’s Jabari Small went for 127 yards and Ole Miss’ Quinshon Judkins racked up 111 yards. Look for Gibbs to follow suit with Alabama ideally leaning on the run game to string together longer possessions and keep the dangerous LSU offense off the field. Plus, Gibbs is fresh coming off a bye week and will be ready for a workload of 15-20 carries or more.

Moose Muhammad, Texas A&M WR – OVER 53.5 Receiving Yards

Before Week 5, Moose Muhammad was barely getting playing time in the Texas A&M offense. Since then, he’s become a top receiver for the Aggies while stepping into a bigger role with Ainias Smith out for the year. Muhammad has gone over 53.5 yards in three of the last four games while tallying at least six receptions in those contests. Last week with Conner Weigman getting the start at QB, we saw Muhammed go off for eight catches, 112 yards, and a TD. The pair should continue that connection this week with Weigman likely starting again. Florida’s defense is allowing 287.2 passing yards per game during conference play with the secondary struggling. 

Jayden Daniels, LSU QB – OVER 255.5 Pass+Rush Yards

This number seems too low when you consider Jayden Daniels’ recent performances and the potential game flow of this matchup against Alabama. First off, the LSU quarterback has thrown for at least 248 yards in four of the last five games. He’s also run for at least 37 yards in all but one contest this season. Overall, Daniels is averaging 292 combined rushing and passing yards per game this year. He’s gone over this 255.5 line in six of eight games and three straight coming into this week. If Alabama takes an early lead and maintains it into the second half, we should see Daniels throwing it a bunch and trying to make plays with his legs throughout the game. The LSU offense leans on his dual-threat playmaking when needed and this week should call for Daniels to be heavily involved as a passer and runner. 

Will Shipley, Clemson RB – OVER 84.5 Rush Yards

Clemson has a tough matchup this week on the road at Notre Dame. On the surface, it may be asking a lot for Will Shipley to go for 85+ rushing yards – but some key trends point us in that direction. First off, we should see Clemson lean on the run and feed Shipley a lot in this one to take the pressure off of QB DJ Uiagalelei. That's been the case the last two games when Shipley saw 20 and 27 carries while going for 121 and 172 rushing yards, respectively. He also went for 104 yards on 20 carries in another recent game. Notre Dame's rush defense is decent against the run, but it has given up some big games to opposing rushers. UNLV's Courtney Reese had 142 yards, Stanford's Casey Filkins went for 91 yards, and BYU's Christopher Brooks had 86 yards. That's three RBs in the last four matchups who went over this line, and not all had the rushing volume that Shipley should get.


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