College Football Week 6 is here and we have your top CFB DFS picks and lineup strategies for Saturday's main slate on DraftKings and FanDuel! This Saturday's CFB Week 6 main slate is loaded with top matchups like Oklahoma vs Texas, Alabama vs Texas A&M, LSU vs Missouri, and Washington State vs UCLA. In this CFB DFS Playbook, we'll break down top college football DFS picks for Saturday's main slate on DraftKings and FanDuel for the early/afternoon games. Check out Pete Cole's playbook for the night slate breakdown. The FanDuel main slate includes some night games as well, but you can check out these top picks when building CFB DFS lineups on both sites. All the CFB Week 6 odds listed below are via DraftKings Sportsbook at the time of this writing. Let's now get into the top CFB DFS picks for Saturday's college football Week 6 slate on October 7th.


College Football Week 6 Schedule – CFB DFS Saturday Main Slate 

  • 12 pm ET – Oklahoma vs Texas (-5.5) – 60.5 O/U
  • 12 pm ET – LSU (-5) at Missouri – 64.5 O/U
  • 12 pm ET – Maryland at Ohio State (-19.5) – 57 O/U
  • 12 pm ET – Rutgers at Wisconsin (-13) – 44 O/U
  • 3 pm ET – Washington State at UCLA (-3.5) – 60.5 O/U
  • 3:30 pm ET – Wake Forest at Clemson (-21) – 52.5 O/U
  • 3:30 pm ET – Virginia Tech at Florida State (-24) – 53 O/U
  • 3:30 pm ET – Syracuse at North Carolina (-9.5) – 60 O/U
  • 3:30 pm ET – Alabama (-2.5) at Texas A&M – 46 O/U
  • 3:30 pm ET – Purdue at Iowa (-2.5) – 39 O/U
  • 4 pm ET – UCF (-1.5) at Kansas – 64 O/U
  • 4 pm ET – Vanderbilt at Florida (-18.5) – 51.5 O/U


College Football Week 6 CFB DFS Picks

Top CFB DFS Quarterbacks

Jayden DanielsLSUMIZZ900037.731240035.49
Jayden Daniels continues to put up big numbers in this high-scoring LSU offense after dropping 50 DK last week in the shootout vs Ole Miss. Considering LSU’s poor defense will allow opposing teams to score plenty on their own, Daniels should be busy and plenty productive from a dual-threat DFS standpoint every week. He now has a 16:2 TD:INT ratio and three rush TDs over five games while averaging 342 passing yards and 58 rushing yards per contest. The DFS floor/ceiling combo is one of the best in the sport right now and he’s a top play in this high-scoring matchup vs Missouri. The Mizzou pass defense is below-average and shouldn't slow Daniels down, even on the road.
Quinn EwersUTOU850027.61040026.30
The Red River Rivalry games are usually shootouts, so both QBs are viable plays in all formats. If choosing between Dillon Gabriel and Quinn Ewers, though, the latter is the slightly safer play at cheaper prices on both sites. Ewers has been a solid cash play with 30+ DK upside at his best. The rushing TDs for Ewers this season are a surprising bonus as he’s now run for 5 scores, including two last week. The Texas defense is very good and could limit Gabriel, but Ewers has proven he can put up numbers in tough matchups (see Alabama game).
Kyle McCordOSUUMD810017.05840016.05
Kyle McCord likely goes overlooked on this slate with so many other higher totals not involving Ohio State, but that makes him a contrarian GPP option. McCord was limited last game vs Notre Dame’s strong defense and a bounceback could be coming here at home after the bye week. Maryland’s D looks good on paper but it also hasn’t faced any good offenses. The Terps have historically given up a ton of points to the Buckeyes and McCord is gaining confidence running the attack. Again, limit to GPPs, but a 30+ DK effort can come at lower rostership than other top QBs. He's also underpriced on FD, so it's a potential Super-Flex value over there.
John Rhys PlumleeUCFKU790025.711000025.21
After sitting out the last three games, John Rhys Plumlee is trending towards playing this week as he returns from a leg injury. He’s been back at practice and the spread has flipped over to UCF being favored here, both good signs that he could play. If he does, then this matchup vs Kansas is a tasty one. The KU defense just gave up 661 total yards and 40 points to Texas last week and 366 total yards and 27 points to BYU the week before. UCF’s offense with Plumlee back under center is somewhere in between those two and closer to Texas. We know he has the dual-threat upside, which was on full display in Week 1 with 35 DK, 90 rushing yards, and 4 total TDs. Maybe his rushing is limited coming off injury, but the GPP ceiling is still there in a high-total matchup. If Plumlee sits again, then Timmy McClain has filled in nicely and is an easy pivot.
Brady CookMIZZLSU740026.681080026.46
The LSU pass defense has veen very beatable this season and Brady Cook should have plenty of success through the air in this matchup. We just saw Jaxson Dart throw for 389 yards with 4 TDs last week vs LSU as the pass D ranks 110th nationally so far. Cook has a perfect 11:0 TD:INT ratio through five games while averaging 293 passing yards per contest. The Mizzou offense is rolling with Cook under center. He’s put up 31, 26, and 35 DK in the past three games with 340+ pass yards and multiple TDs thrown in each. Cook could be a popular cash Super-Flex and he’s very affordable on DK.
Garrett ShraderSYRUNC720029.42960028.33
Last week vs Clemson, Garrett Shrader didn’t return value with just 15 DK – but that’s understandable in a tough matchup. Things should be easier in a higher-total game vs an unproven UNC defense this time. Shrader’s dual-threat upside is what we love for DFS as he already has 340 rushing yards and 6 rush TDs through five games. The cash floor is on the higher end with the running ability and we should get 25 DK or so in this spot. His DK price tag makes him a value while he’s priced a bit too high on FD.
Kyron DronesVTFSU540016.24900015.64
If you want to roll the dice on a cheap DK quarterback, look at Kyron Drones in GPPs. He’s started the past three games for Virginia Tech with Grant Wells out and put up 17, 24, and 36 DK. Wells might be out again with the ankle injury, but definitely monitor the situation ahead of the 3:30 pm ET kickoff. If Drones starts, then his dual-threat upside alone puts him in play. He has 190 rushing yards over the past three games with 2 rush TDs in back-to-back weeks. He’s also looking to run a ton as he’s credited with 22, 15, and 21 carries in these last three contests. The matchup vs Florida St is definitely tough and makes him risky, but Drones could return value with the rushing.

Top CFB DFS Running Backs

Braelon AllenWISCRU840025.55  
For the most part, Braelon Allen has not disappointed this season as a top DFS running back. He has performances of 38, 23, and 30 DK with good stat lines and 2 rush TDs in all three games that Wisconsin led and won. Allen was splitting work with Chez Mellusi, but he now should be locked into a bigger workload with Mellusi out for the year. Allen will face a Rutgers rush defense that allowed 201 rush yards to Michigan in its only real test this season. Blake Corum ran for 97 yards and 2 TDs in that game, and we could see a similar or better outcome for Allen. If you can fit him in, he’s a top cash RB on the DK slate.
TreVeyon HendersonOSUUMD740017.5860016.38

UPDATE: Henderson is OUT today, so it's now Miyan Williams and Chip Trayanum as the top guys in Ohio St's backfield. Trayanum at $4200 on DK is an interesting value now in both GPP and cash. 

All of the Ohio State guys are likely contrarian GPP upside plays on this slate. TreVeyon Henderson is in that boat, but he could easily be one of the top RB scorers. While he’s splitting work with Miyan Williams and Chip Trayanum in the OSU backfield, Henderson is the lead back. He’s coming off a 100-yard performance vs Notre Dame and is poised for one of those breakout games. Last year vs Maryland, by the way, Dallan Hayden had 146 rushing yards and 3 TDs while Henderson was limited by injury. The Terps rush defense is good on paper but also hasn’t any good offenses yet.

Jonathon BrooksUTOU670023.66950021.38
Jonathon Brooks has now reeled off three straight impressive stat lines coming into this Red Rivalry matchup. He just put up 207 rushing yards, 2 TDs, and 40 DK last week vs Kansas and has 100+ yards in three straight games. CJ Baxter is still involved, but Brooks is getting lead back carries for Texas. He’ll face an Oklahoma rush defense that has been good this season, but it also hasn’t faced a rushing attack or offensive line as good as Texas’. The GPP upside is there if Texas finds success on the ground and leans on Brooks. In last year’s matchup vs OU, Bijan Robinson had 130 yards and 2 TDs – a stat line we could see from Brooks.
Trey BensonFSUVT660014.68830013.68
Florida State gets the best rushing matchup on the slate with the Virginia Tech rush defense allowing 177.6 yards per game (110th in FBS). We’ve seen Marshall’s Rasheen Ali, Rutgers’ Kyle Monangai, and even Purdue’s Devin Mockobee have big games in this matchup already. Trey Benson can follow suit with 100+ yards and multiple scores if he gets the work. That’s the only worry as he’s only averaging about 10 carries per game so far. Still, the GPP upside is there at home in a soft matchup and Florida State favored big.
Devin NealKUUCF630022.281020020.38
The UCF rush defense is one of the worst on this slate, allowing 156.8 rush yards per game (94th in FBS). This D has gotten torched on the ground the last two games vs Big 12 opponents with Kansas State going for 281 rush yards and 6 rush TDs and then Baylor gaining 153 yards and 2 scores via the rush. It sets up nicely for Devin Neal to bounce back from his poor stat line last week vs Texas in a tough matchup and in a game where Kansas was trailing the whole time. Neal can get back to his 25-30 DK performances we saw earlier this year, and Jalon Daniels being out should boost his carries more. He’s a bit underpriced on DK considering he’s the most expensive RB on FD.
LeQuint AllenSYRUNC580022.72890020.35
LeQuint Allen just continues to produce on weekly basis for DFS and he’s still fairly affordable on both sites. The Syracuse lead back now has at least 19 DK in every game so far and even came through last week against a tough Clemson defense. He’s getting workhorse rushing volume and is also involved as a pass-catcher with 15 catches and 123 receiving yards combined over the past three games alone. The UNC rush defense has allowed good games to three straight opposing lead RBs, so Allen can follow suit and return value in cash or GPP.
Carson SteeleUCLAWSU560014.85  
Carson Steele is still splitting work with Harden, which limits his floor/ceiling for DFS. Even so, Steele has been productive when given the carries, averaging 6.6 ypc. This matchup looks to be a favorable one as Wash St allowed 242 rush yds and 4 rush TDs to Oregon St last game. UCLA will likely try to pound the run game with Steele and Harden to take pressure off of Dante Moore and keep the ball away from Washington St’s offense. We could be looking at the first 100-yard game from Steele here with a TD or two at his best. The DK price is cheap to roster as a cash RB.
Nathaniel PeatMIZZLSU560011.2659009.55
The Missouri backfield is split between Cody Schrader and Nathaniel Peat, yet the latter is much cheaper on both sites. Though Schrader has been more productive this year, Peat has seen double-digit carries in three of five games while averaging 4.6 ypc on the season. He’s also a slightly better pass-catcher, which could be key if Mizzou is trailing and passing more in this matchup vs LSU. Overall, Schrader is priced too high to play but Peat can put up similar numbers while costing a lot less. He’s also way cheap on FD and could be a decent GPP value in a high-scoring game.
Johnny RichardsonUCFKU480011.68610011.20
Last week vs Texas, the Kansas rush defense gave up 336 rushing yards and 4 rush TDs. Yes, it was against a strong Longhorns’ offense, but UCF has a good run game too and can exploit this matchup. RJ Harvey is definitely in play as the team’s lead back. Johnny Richardson, though, is much cheaper for possibly similar DFS production. He’s averaging 8.8 ypc and 78.8 rush yards per game so far as the more explosive back compared to Harvey. With John Rhys Plumlee possibly back, that could take away some rushing upside – but Plumlee is coming off a leg injury and might not run it as much. There’s clear GPP potential for Richardson, especially if he can break a long gain or two like last week when he had a 79-yard rush TD.

Top CFB DFS Wide Receivers

Marvin Harrison Jr.OSUUMD890018.82960015.20
The Ohio State offense was held down by Notre Dame last game and Marvin Harrison Jr. only had three catches for 32 yards while also spraining his ankle. Reports this week indicate Harrison is back practicing and should be good to go following OSU’s bye. This is also now a much easier matchup vs an untested Maryland defense. The DK price tag is really high, so that puts him more in GPP territory. We know the ceiling, though, as he showed in Weeks 2 and 3 with 38 and 27 DK, respectively. If Harrison does end up sitting, Emeka Egbuka and Julian Fleming get a boost up.
Luther Burden IIIMIZZLSU690029.921000024.20
If you haven’t noticed, Luther Burden has been a DFS and real-life stud this season. He has at least seven catches, 96 yards, and 22 DK in every game so far and is coming off three straight 30+ DK performances. Burden is excelling in the slot role in Mizzou’s offense and he’s the clear-cut top target for Brady Cook. The two should combine for a ton of production against a rough LSU pass defense that just got lit up by Ole Miss. Even though he’s in the same price range as the LSU wideouts, Burden might be top overall WR play on this slate.
Malik NabersLSUMIZZ650028.31030023.83
The LSU passing attack features Malik Nabers and Brian Thomas pretty heavily as both will be weekly top plays. We’ll get to Thomas in a second, but Nabers has come on very strong in recent weeks. We all remember the slate-breaking Week 3 stat line of 13 catches, 239 yards, 2 TDs, and 51 DK. Well, he’s followed that up with 36 and 21 DK in the past two games with eight catches and 100+ yards in both. The Missouri pass defense ranks 90th nationally and has had trouble covering receivers from Kansas St, Memphis, and Vandy. Do we really think it’ll hold Nabers down? The DK prices for both Nabers and Thomas are criminal as these guys should not be cheaper than 7k.
Brian Thomas Jr.LSUMIZZ610028.741010023.85
Like his teammate Malik Nabers, we have Brian Thomas as another top WR play from the LSU offense. It’s tough choosing between these guys every week, but Thomas’ slightly more consistent production this season might make him the better option. He has at least 25 DK in four of five games with multiple TDs in three of those. He also has 120+ receiving yards in three contests and 6+ catches in four games. Thomas is a future NFL wideout, like Nabers, and both will be producing on a weekly basis. Expect Thomas to be more popular in DK cash with the $6100 price tag. That’s just way too cheap.
Kobe HudsonUCFKU560017.76660012.90
Kobe Hudson was held to only one catch last week, but that’s very uncharacteristic from what we saw the previous three games. He had at least five catches, 134 receiving yards, and 21 DK in each of the prior three weeks. Expect Hudson to bounce back against a below-average Kansas pass defense that just got torched by Texas last week. John Rhys Plumlee could return, but Hudson had been producing with Timmy McClain at QB too.
Theo Wease Jr.MIZZLSU550013.42730012.10
If you don’t want to pay up for Luther Burden, then Theo Wease is a cheaper way to get exposure to the Mizzou passing attack against this poor LSU secondary. Wease is the clear second receiver behind Burden and he’s scored a TD in three of the last four games. The former Oklahoma transfer is coming off a big game last week with 10 receptions, 118 yards, a TD and nearly 30 DK. Expectations should be lower than that, but there’s definite upside in this matchup with a high-total game flow.
Adonai MitchellUTOU540016.24760013.44
Last week, Adonai Mitchell broke out for 10 receptions, 141 yards, a TD, and 32 DK. He had been relatively quiet early on this season while finding his role in the Texas offense, but more targets should be coming. Xavier Worthy is still there and a top weapon for Quinn Ewers, but last week’s connection with Mitchell is a good sign. Keep an eye on Ja’Tavion Sanders’ status pre-game as he’s dealing with an injury suffered last week. If Sanders is out, then Mitchell gets a big boost as one of Ewers’ clear-cut top two targets with Worthy. If we start seeing more stat lines like last week, which is very possible based on Mitchell’s NFL-level talent, then he’s way underpriced on both sites.
Kyle WilliamsWSUUCLA540018.05  
Kyle Williams stepped up big time last game with Lincoln Victor getting hurt early. Williams put up 33 DK with his seven catches, 174 yards, and a TD. With Victor expected out this week, Williams should be a top target for Cameron Ward alongside Josh Kelly. You can look at Kelly too, but Williams is the contrarian cheaper play He’s also now caught a TD in every game thus far with 12+ DK in each contest.
Ainias SmithTA&MBAMA530013.16650010.36
After starting the season slow, Ainias Smith has been more and more involved in the Texas A&M offense in recent games. He had those 127 yards back in Week 3 but also has at least 70 receiving yards and four catches in back-to-back games since. Smith has taken advantage of a bigger role with both Evan Stewart and Noah Thomas nursing injuries. Both of them should play, but Smith’s playmaking ability will be key vs Alabama’s stout defense. He’ll fly under-the-radar on this slate, but is a solid value in all formats.
Tyler BrownCLEMWAKE530028.4790021.40
We mentioned Tyler Brown as a value last week and he came through big time with eight receptions, 151 yards, and 28 DK. He’s now a clear top playmaker for Clemson’s offense with three straight good games. Brown has also taken advantage of a bigger role with Antonio Williams sidelined with an ankle injury. Though Williams is trending towards playing this week, Brown should still be a top target for Cade Klubnik. He’s still a good value in all formats on both sites.
Erick AllIOWAPUR42009.06  
With so many high-scoring games on the slate, can we really consider someone from Iowa? Well, Erick All is cheap enough to return value for DK cash lineups. For some quick context, Hawkeyes tight end Luke Lachey was the team’s top offensive weapon but he’s out for the season. All, a Michigan transfer, has seen an uptick in targets as Iowa’s lead TE now and his floor is safer. Last week, he had four receptions for 67 yards and a TD for 16 DK – which coincided with backup QB Deacon Hill playing most of the game. With Cade McNamara out this week, Hill could be looking All’s way for easy completions – especially against a below-average Purdue pass defense.
Devontez WalkerUNCSYR300005000 
In a surprising twist, Devontez Walker was just ruled eligible to play for UNC this week. The Kent State transfer had previously been denied a waiver by the NCAA and it looked like he might have to sit out all year. Now, Walker should be active on Saturday and he could quickly emerge as Drake Maye’s top target as early as this week. Walker had 921 receiving yards and 11 TDs last year for Kent St and transferred to UNC to seemingly replace Josh Downs as the top WR. He’s min price on DK and only $5000 on FD, so expect him to be chalky in all formats. It might be one of those free squares and allows you to pay up elsewhere.


CFB DFS Week 6 Core Plays 

DraftKings Cash

  • Brady Cook – Missouri
  • Malik Nabers and/or Brian Thomas Jr. – LSU
  • Devontez Walker – UNC

DraftKings GPP

  • Jayden Daniels – LSU
  • Devin Neal – Kansas
  • Luther Burden – Missouri

FanDuel Cash (Early Games)

  • Quinn Ewers – Texas
  • Luther Burden – Missouri
  • Devontez Walker – UNC

FanDuel GPP (Early Games)

  • Jayden Daniels – LSU
  • Trey Benson – Florida State
  • Marvin Harrison Jr. – Ohio State

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