The 2025 College Football season rolls on with a full Saturday slate of Week 10 games. Welcome to our CFB Best Bets as we break down CFB picks for this week’s action. Let’s focus on two matchups for our top CFB predictions. Plus, check out more college football bets below.  

Saturday’s Week 10 college football slate lasts all day and all night. That means we have plenty of ways to go for our CFB picks. Note that all bets below are for one unit unless otherwise noted. Without further ado, let’s dive into our CFB Best Bets. 

CFB Picks, Predictions & Best Bets: Week 10 Saturday, 11/1

Let’s kick off Saturday’s Week 10 CFB Best Bets with a Top 25 SEC matchup between No. 20 Texas and No. 9 Vanderbilt. Plus, San Diego State hosts Wyoming in a Mountain West showdown. Be sure to check out more CFB picks below for other notable Week 10 games, including Georgia vs. Florida and Miami (FL) vs. SMU. That includes some intriguing college football player props as well. Good luck!  
 

 

 

Vanderbilt vs. Texas Prediction: Saturday, November 1st

One of the biggest games this week features No. 20 Texas hosting No. 9 Vanderbilt. It’s a very intriguing showdown between a Commodores team that’s taken the college football world by storm, and a Longhorns squad that hasn’t totally lived up to expectations thus far. Let’s make a pick in this Top 25 matchup. 

Vanderbilt’s 7-1 start to the season is very impressive. Diego Pavia is rightfully in the Heisman conversation, and his team looks like a real College Football Playoff contender. However, it’s time to sell the Commodores as they travel to Austin on Saturday. 

Notably, this will be Vandy’s first road game in a month since losing 30-14 at Alabama on October 4th. It’s also just the second time on the road for the ‘Dores over the past six games. Plus, this is the end of a tough stretch in the schedule, having to face a trio of top 15 teams in a row ahead of this week’s matchup. 

It’s fair to wonder how much Vanderbilt has left in the tank. The Commodores benefited from facing LSU and Missouri at home in the past two weeks. That likely helped them pull out one-score victories in both games. It’ll be a much different test on the road at Texas, especially against an elite defense, which we’ll get to shortly. 

Meanwhile, the vibes are deservedly low on the Longhorns right now. Texas is still 6-2 on the season, but it just squeaked out overtime wins against both Kentucky and Mississippi State in the last two weeks. Plus, the preseason betting favorites to win the national title have lost two of their toughest matchups of the year (Ohio State, Florida). 

Despite all of that, Texas has a prime opportunity to vault back into Playoff contention with a statement win over Vanderbilt at home here. The Longhorns will be playing their first true home game in over a month. That cannot go overlooked for a team that just showed it can survive on the road, even when it’s not at its best. 

On that note, Texas does deserve some credit for winning its past two road games. Plus, the ‘Horns can carry over momentum from last week’s comeback win. They overcame a 17-point fourth-quarter deficit to eke out the victory in OT against a feisty Mississippi State team. 

As for this week’s matchup, Vanderbilt’s offense may struggle against the top-tier Texas defense. The Longhorns are allowing just 14.6 PPG this season (10th in FBS) and rank 8th nationally in defensive EPA. The unit is especially dominant vs. the run, ranking 3rd in the country in both rushing yards allowed per game and EPA/Rush defensively. 

Vanderbilt relies on its ground game plenty, with dual-threat QB Diego Pavia and RB Sedrick Alexander forming a dangerous 1-2 punch. The Commodores are 24th in rushing offense and 4th in EPA/Rush. However, Texas has the defensive fortitude to slow down Pavia and the run. It also helps that the Longhorns faced Vandy and Pavia last year, so they know how to gameplan against the offense. 

On the other side, the Texas offense has been up and down all year. Arch Manning is admittedly inconsistent, and the Longhorns’ rushing attack has underperformed. Yet, we just saw the offense explode for 428 total yards last week amid that big second-half comeback. Manning threw for 346 yards in one of his best games of the year. 

Speaking of Manning, he got knocked out of last week’s game with a concussion and is questionable to play. However, he’s been practicing, and it appears he’ll be cleared ahead of Saturday. With Manning under center, Texas can move the ball well through the air as Vanderbilt ranks 89th in passing yards allowed vs. FBS opponents and 112th in EPA/Pass allowed. We saw Alabama QB Ty Simpson put up 340 passing yards in this matchup not too long ago. 

Take the Longhorns to cover the spread in their win at home. It’s worth noting that Texas is 20-3 straight-up at home over the past four seasons combined. 

 

 

 

Wyoming vs. San Diego State Prediction: Saturday, November 1st

Let’s now turn our attention to the Mountain West Conference as Wyoming takes on San Diego State. The over/under is a low one, at 42.5 as of this writing. Even so, we’re grabbing the under in a game where both defenses can shine. 

It starts with San Diego State’s top-tier defense. The Aztecs are allowing just 10.4 PPG this season, which is the second-fewest in the entire sport behind only Ohio State. They also rank 9th nationally in total yards allowed per game, 6th in defensive EPA/Play, and 5th in defensive success rate. 

This Aztecs' defense is shutting down both the pass and run as well. SDSU ranks 10th in the country in EPA/Pass and 8th in success rate vs. the pass. Plus, the defense is 9th in success rate vs. the run and 27th in EPA/Rush allowed. 

Wyoming will have an extremely tough time scoring in this matchup. The Cowboys are averaging just 19.6 PPG vs. FBS opponents this season (108th in the country). They’ve been putting up points recently, but have also benefited from facing weaker defenses. The competition now ramps up on the road. 

On the other side, Wyoming brings in a solid defense itself. The unit ranks 32nd in the country in points allowed per game (19.8), 47th in total defense, and 27th in defensive EPA/Play. The Cowboys are especially strong against the pass, ranking 27th nationally in passing yards allowed per game and 16th in EPA/Pass. 

In this matchup, San Diego State could have issues putting together successful drives. The Aztecs’ offense is a below-average one. They rank 90th in total yards per game, 80th in offensive success rate, and 74th in offensive EPA/Play. 

 

 

Best CFB Prop Bets & Other Picks: Saturday, 11/1

 

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