As we head into Week 10 of the 2025 NFL season, the quarterback landscape is heating up with a mix of established stars, breakout rookies, and resurgent veterans vying for DFS dominance on DraftKings and FanDuel. This guide breaks down the top-tier studs poised for explosive outings, mid-tier options offering reliable floors with upside, value plays that won't break the bank, and the fades to steer clear of in tough matchups. Whether you're stacking for GPP glory or crafting cash-game stability, let's dive into the picks that could elevate your lineups this slate.

 

 

 

NFL DFS QB Top Tier Picks for Week 10

Lamar Jackson, QB Baltimore Ravens

Jackson has been electric in limited action this season, appearing in just five games but posting an elite 72.9% completion rate, 1,073 passing yards, 14 touchdowns, and only one interception for a sky-high 136.7 passer rating. His dual-threat ability adds significant upside, and I expect him to exploit the Vikings' defense on the ground as well. Minnesota's pass defense ranks 17th, allowing 1,556 yards and 13 touchdowns. Bolstering this matchup, the Vikings sit at 15th in defensive DVOA through Week 9, meaning they're a middling unit overall that's shown vulnerabilities Jackson can capitalize on with his arm and legs. This is a favorable spot for him to rack up fantasy points. 

Drake Maye, QB New England Patriots

Maye has emerged as a breakout option in his sophomore season, owning a 74.1% completion percentage, 2,285 passing yards, 17 touchdowns, and four interceptions, good for a 116.9 rating. His mobility boosts his floor as he is still able to break off chunk yardage as he evades pressure. Facing the Buccaneers, who rank 12th in pass defense, Maye has a solid opportunity to produce top-tier numbers. Even with the possibility that Kayshon Boutte will not be available for this game, we’ve seen Maye show the ability to still make big plays to the likes of Pop Douglas, Stefon Diggs, and Mack Hollins this season.

Baker Mayfield, QB Tampa Bay Buccaneers

Mayfield continues to perform steadily, completing 63.9% of his passes for 1,919 yards, 13 touchdowns, and two interceptions for a 98.1 rating. This game could turn into a shootout, boosting Mayfield's ceiling, especially against New England's 25th-ranked defensive DVOA against the pass, which highlights their struggles in efficiency and opens the door for Mayfield to exploit mismatches. 

 

 

 

NFL DFS QB Mid-Tier Picks for NFL Week 10

Caleb Williams, QB Chicago Bears

Williams has shown flashes this season, which include last week's huge win against the Bengals. The Giants' defense ranks 29th against the pass, allowing 2,089 yards, 15 touchdowns, and four interceptions this season. With New York checking in at 28th in defensive DVOA, they're one of the league's softer units, giving Williams plenty of room to build on his recent momentum in what should be a comfortable home matchup. This exploitable spot makes him a strong mid-tier play. 

Sam Darnold, QB Seattle Seahawks

Darnold is enjoying yet another huge year, boasting a 70.4% completion rate for 2,084 yards, 16 touchdowns, and five interceptions. Arizona's pass defense is solid but not elite, and Darnold's hot streak could help him navigate this one effectively, especially if newly acquired Rashid Shaheed is able to suit up for Seattle this weekend. Look for Darnold to be a solid mid-tier value this weekend.

Jaxson Dart, QB New York Giants

Jaxson Dart, in his rookie year, has completed 62.3% of his passes for 1,175 yards, 10 touchdowns, and three interceptions. His fantasy value is definitely carried by his mobility as a QB, where he has five rushing touchdowns on the season. The Bears' defense ranks 27th in DVOA against the pass and underscores their defensive woes, setting up Dart for a potential breakout if he can avoid turnovers against a leaky secondary. This vulnerable matchup positions him well as a mid-tier option. 

 

 


 

NFL Week 10 DFS QB Value Picks

JJ McCarthy, QB Minnesota Vikings

J.J. McCarthy has completed 38 of 66 passes (57.6%) for 444 yards, four touchdowns, and four interceptions this season. The Vikings offense is loaded with weapons at the receiver position, which is obviously led by Justin Jefferson but also includes Jordan Addison and T.J. Hockenson. Baltimore's pass defense ranks 21st in DVOA, indicating they're around average but with some exploitable gaps that McCarthy's low price tag makes him an intriguing value if the game script favors passing. 

Mac Jones, QB San Francisco 49ers

Jones has played in seven games, completing 168 of 250 passes (67.2%) for 1,832 yards, 10 touchdowns, and five interceptions in place of the injured Brock Purdy. This week, the 49ers face the Rams' ranked pass defense, which is tough, but if Jones is more than capable of hitting his value in Shanahan's scheme, as we’ve seen this season, he could still yield sneaky upside. 

 

 


 

NFL DFS QB Fades for Week 10

Trevor Lawrence, QB Jacksonville Jaguars

Lawrence has struggled in eight games, completing just 59.7% of his passes for 1,840 yards, nine touchdowns, and six interceptions. This week, he faces the Houston Texans, who boast the top-ranked pass defense, allowing just 1,420 yards with eight touchdowns and nine interceptions. On top of that, the Texans lead the league in defensive DVOA, making them a nightmare matchup that's likely to stifle Lawrence's production. This stifling setup makes him a clear fade.Â