Welcome back to another round of MLB Best Bets Today as the 2025 baseball season rolls on. 

Tuesday’s MLB slate is another loaded one with 14 games on the baseball schedule. With nearly every team in action, there are plenty of ways to go for our MLB picks and predictions. Let’s focus on two games for our MLB best bets today before dishing out a few baseball player props and other picks to consider. 

The MLB picks below are accurate as of this writing, but some odds or lines could move before first pitch. All bets below are for one unit unless otherwise noted. Without further ado, let’s dive into our MLB Best Bets Today.

MLB Picks, Predictions & Best Bets Today, 9/2

Our MLB Best Bets Today start with the St. Louis Cardinals hosting the Athletics in a potential pitcher’s duel. Plus, the Boston Red Sox look to stay hot against the Cleveland Guardians. Don’t miss more MLB picks and player props below. Check out these MLB predictions to make as you enjoy Tuesday’s baseball action. 

 

 


 

Athletics vs. St. Louis Cardinals Predictions: Tuesday, September 2nd

Let’s start with an interleague matchup between the Athletics and St. Louis Cardinals. We have a pair of veteran starting pitchers in this one with Luis Severino and Miles Mikolas on the mound. Let’s bank on both to anchor a lower-scoring game. 

At first glance, Mikolas and his 5.04 ERA are hard to trust. Plus, he’s been very up-and-down over the past two months. However, much of his failure and success can be attributed to notable home/road splits. The St. Louis right-hander has been much better at home with a 3.57 ERA and .278 wOBA allowed, compared to a 6.79 ERA and .414 wOBA on the road. 

Mikolas also owns a 2.16 ERA over his past 6 home starts. Plus, he’s allowed 2 earned runs or fewer in 6 of his last 7 home outings. Conversely, he’s coughed up 5+ runs in 5 straight road starts. We get him at home for this matchup, though. 

The Cards’ starter will now face an Athletics offense that’s been bottom-tier against right-handed pitching lately. Over the past two weeks vs. righties, the A’s have a .299 wOBA (24th in MLB), 86 wRC+ (25th), and 24.9% K rate (24th) in the split. It’s a lineup that Mikolas can limit, especially at home. 

On the other side, Severino makes his return to the A’s rotation after missing nearly a month with an oblique injury. He probably won’t go too deep in his first start back, but he can still be effective. The right-hander was pitching well before the IL stint, with a 2.93 ERA and 2.62 FIP over his past 5 starts. 

Severino’s home/road splits are also very eye-opening, but in the opposite way from Mikolas. At home, the Athletics’ starter has struggled to a 6.34 ERA in a hitter-friendly park. Compare that to a 3.17 ERA on the road, including 2 or fewer runs allowed in 8 of 11 road starts this season. 

With Severino on the road here, he’ll get a favorable matchup, too. The Cardinals are hitting just .186 against right-handers over the past week (28th in MLB) with a 27.8% K rate (27th) as well. Over the past month, St. Louis has had a .279 wOBA (29th) and 78 wRC+ (28th) vs. righties. 

 

 


 

Cleveland Guardians vs. Boston Red Sox Predictions: Tuesday, September 2nd

The Boston Red Sox and Cleveland Guardians are headed in opposite directions in the AL Wild Card race. The Sox are 9-3 over their last 12 games and trending up. Meanwhile, the Guardians are just 5-11 over their last 16 games and now have very slim playoff odds. Boston won yesterday’s series opener, 6-4, and we’re backing the home favorites again today. 

Garrett Crochet starts for Boston, which is usually a good thing. The southpaw owns a 2.40 ERA this season with 214 strikeouts, just 2 behind Tarik Skubal for the MLB lead. His Statcast profile is a sea of red, headlined by a 31.1% K rate (92nd percentile), 32.3% chase rate (90th), 6.1% walk rate (83rd), and .221 xBA (81st). 

Crochet is dealing lately. He boasts a 2.42 ERA and 2.84 FIP over his past 8 starts. The Red Sox lefty is also elite at home, sporting a 2.33 ERA and a .210 batting average allowed. He’s allowed 2 earned runs or fewer in 10 of 12 home starts as well. 

Now Crochet gets an easy matchup against a slumping Cleveland offense. The Guardians have especially been terrible vs. left-handed pitching over the past month, with a .247 wOBA (30th in MLB), 55 wRC+ (30th), and .175 BA (30th). Over the past two weeks vs. lefties, they’re hitting just .136 with a .190 wOBA (both dead last in the majors). 

As Crochet does his thing, bank on run support from the Boston offense against Cleveland starter Slade Cecconi. The righty has a 4.41 ERA this season, and his 4.90 FIP and 5.61 xERA suggest some negative regression. He’s struggled to a 7.32 ERA over his past 4 starts and a 5.55 ERA over his last 8 outings. 

The Red Sox, meanwhile, have a top-tier offense vs. right-handed pitching recently. Over the past two weeks in the split, Boston has a .341 wOBA (7th in MLB), .268 BA (5th), .781 OPS (7th), and 115 wRC+ (7th). It’s a tough spot for Cecconi, who’s been shaky lately. 

Take Boston to cover the runline en route to a victory. Bank on Crochet to anchor a comfortable win. The Red Sox are 12-3 in his last 15 starts, with 9 of those wins coming by 2+ runs. 

 

 

Best MLB Player Prop Bets & Other Picks Today, 9/2

 

Â