Welcome back to another round of CFB picks and college football best bets for Saturday's Week 10 CFB schedule. The college football picks went 2-0 in last week's article with Oklahoma State and NC State both coming through. Plus, we went 6-1 combined with CFB bets on the Bettor Sports Betting show. Our CFB Week 10 best bets feature a marquee SEC showdown of Missouri vs Georgia. We also have picks for Jacksonville State vs South Carolina and Kansas vs Iowa State. Enjoy these CFB picks and college football predictions as you tune into the Week 10 games. Plus, keep an eye out for the CFB DFS Playbook for top Week 10 college football daily fantasy picks. Let's now get to the college football best bets and CFB betting picks for Saturday, November 4th.

 

College Football Week 10 Best Bets 

Jacksonville State at South Carolina 

Saturday, 12 pm ET

South Carolina’s season has taken a turn for the worse with a four-game losing streak and now a 2-6 record overall. The Gamecocks have suffered through their SEC gauntlet of a schedule and are now in real danger of missing out on bowl eligibility. Double-digit losses to Texas A&M and Missouri in the past two games have especially impacted the negative public view of South Carolina – and rightfully so. 

However, this is a perfect get-right spot for the home favorite with an easy non-conference matchup against Jacksonville State. The “other” Gamecocks come in with an impressive 7-2 record and a 5-1 conference mark in their first season in Conference USA. Still, this is a big step up in competition for a team that’s beaten the likes of Florida International, Middle Tennessee, and Sam Houston over the past month. Going on the road in an SEC environment is a whole other beast. Although South Carolina is among the bottom-feeders in its own conference, it still boasts a notable raw talent advantage over Jacksonville State. 

South Carolina has a terrible pass defense, ranking 130th nationally in passing yards allowed per game. Yet, Jacksonville State simply doesn't have the passing attack to exploit the matchup. They rank 121st in passing offense this season, only throwing for 159.7 yards per game. Meanwhile, South Carolina boasts a top-30 passing offense led by NFL prospect Spencer Rattler. They can stretch out a lead against a Jacksonville State defense that has yet to face the athleticism and talent of the South Carolina offense – even though it’s struggled against SEC defenses. 

You might think this is a trap spot for an SEC team in a later-season non-con situation against a C-USA opponent. Could you blame South Carolina for looking past Jacksonville State? Not for a team that’s lost four straight, though. Plus, they desperately need a comfortable victory to build momentum for their final stretch of the regular season. 

Jacksonville State’s toughest opponent and game so far was on the road at Coastal Carolina back in September. They lost by 14 and failed to cover as double-digit underdogs. One of their other toughest matchups was a few weeks ago against Liberty. Jacksonville State lost by 18 and also failed to cover as underdogs. Meanwhile, South Carolina is 2-1 ATS as a favorite this season. That includes a 26-point win over Furman at the beginning of the year, covering the 17.5-point spread. 

PICK: South Carolina -15.5 (-110 BetMGM)

Missouri at Georgia

Saturday, 3:30 pm ET

If you were wondering whether or not Georgia had any real motivation this year after winning back-to-back national titles, well now it does. The College Football Playoff committee slotted the Bulldogs second in this week’s initial CFP rankings, right behind Ohio State – the team it beat in last year’s semifinals. Congratulations to Kirby Smart, who now has some classic bulletin board material to show his players while playing the “no respect” card this week. Considering strength of schedule and each team’s best wins, Ohio State has a legit case of being ranked ahead of Georgia. Not in the eyes of Smart and the Bulldogs, though. 

Apologies ahead of time to Missouri. The Tigers are having one of their best seasons in recent program history. They’re off to a 7-1 start and ranked No. 12 in the initial CFP rankings. This is a great opportunity for Georgia to earn a convincing win over a top-15 team in the country. It would be the Bulldogs’ best win of the season on paper so far and a sizable victory can boost its resume for the aforementioned CFP committee. 

The Missouri offense is dangerous, averaging 33.9 PPG and ranking 30th nationally in total offensive yards per contest. Still, the Tigers have yet to face a defense like Georgia’s yet. In SEC play, Mizzou has benefited from facing Vanderbilt, South Carolina, Kentucky, and LSU – all average or subpar defenses. Meanwhile, Georgia is allowing just 17.4 PPG vs conference opponents (14th-best in FBS). 

Plus, the Bulldogs’ offense is rolling with 43, 37, and 51 points scored in the past three games. Last week, QB Carson Beck and the passing attack looked just fine despite playing without injured star tight end Brock Bowers. While Missouri does boast an above-average pass defense, it also hasn’t faced many top-end offenses – especially from the SEC. When it did, the Mizzou defense gave up 49 points and 533 total yards to LSU in a 10-point loss.

Georgia has been serving beatdowns to quality opponents lately after surviving pair of closer-than-expected wins over South Carolina and Auburn. The Bulldogs beat Florida by 23 points last week and dominated Kentucky by 38 points (covering as 14.5-point favorites in both). Meanwhile, only once has Mizzou been an underdog of more than three points this season and it failed to cover – losing by 10 to LSU as 6.5-point dogs. 

Last year, Missouri actually gave Georgia a scare in a 27-22 loss that easily could’ve resulted in an upset. This time around, the Bulldogs won’t take the Tigers lightly. Plus this year’s matchup is in Athens, Georgia instead of in Columbia, Missouri. The last three meetings in Georgia between these two teams were UGA wins by 37, 27, and 25 points. 

PICK: Georgia -15.5 (-110 BetMGM)

Kansas at Iowa State 

Saturday, 7 pm ET

Kansas (6-2) just pulled off one of its greatest upsets in recent program history, toppling undefeated Oklahoma at home last week. This was the Jayhawks’ first win over the Sooners since 1997 and the team’s first home win over an AP top-10 team since 1984. The hard-fought, back-and-forth game ended with an unsuccessful Hail Mary by the Sooners and then a rightful field-storming by the Kansas home crowd. As impressive as the upset was, we’re fading the Jayhawks this week in a classic letdown spot on the road at Iowa State. 

After a rough start to the year, Iowa State (5-3) has turned its season around and comes in hot. The Cyclones have won three straight heading into this weekend and are tied atop the Big 12 standings with a 4-1 conference record. They also need just one more win to become bowl-eligible – something that seemed unlikely just a month ago. This home matchup vs Kansas is a great chance to get that sixth win with a tough remaining schedule: at BYU, home vs No. 7 Texas, at No. 25 Kansas State. 

Despite a 6-2 record, Kansas’ defense is still a major concern. The Jayhawks are dead last in the Big 12 in total yards allowed vs conference opponents, giving up 478.4 yards per game. The defense has struggled against both the run and pass in Big 12 play. They survived the victory over Oklahoma but also gave up 440 total yards of offense – including 269 on the ground – and benefited from the Sooners going 3-for-12 on third/fourth downs. In its two losses this season, Kansas allowed both Texas and Oklahoma State to run all over them. The Longhorns had 336 and four TDs on the ground while the Cowboys had 218 and two scores via the run. 

Meanwhile, Iowa State has found something in its running game in recent weeks. The Cyclones’ backfield features a solid 1-2 punch in Eli Sanders and Cartevious Norton who complement each other’s strengths and both have looked better lately. In Iowa State’s current three-game win streak, the run game is averaging 4.5 yards per carry and has made up for the lack of consistency and efficiency from QB Rocco Becht.

Kansas, fresh off its upset over Oklahoma and a No. 22 ranking in this week’s AP poll, is ripe for the picking. Night games in Ames, Iowa have a different feel and the Cyclones will be motivated to shake up the Big 12 even more. It’s worth mentioning that although Kansas beat Iowa State last year, 14-11, the Cyclones had previously won seven straight against KU in this series. They are also 11-2 against the Jayhawks in the past 13 meetings. Iowa State has not lost at home to Kansas since 2008, winning each of the past seven home matchups, and will continue that trend this week. 

PICK: Iowa State ML (-145 BetMGM)

Other CFB Week 10 Bets:

  • Arkansas +6
  • Notre Dame/Clemson Under 45
  • Army/Air Force Under 33