A crucial SEC clash is set to take place in Norman this weekend as the rising #8 Oklahoma Sooners welcome the #22 Missouri Tigers in a contest that holds significant implications for the College Football Playoff. Oklahoma's win over Alabama last week revitalized its postseason aspirations and firmly reestablished the Sooners as a credible top-10 contender.

Conversely, Missouri has recently ended its losing streak with a vital victory; however, the Tigers have yet to secure a win against a ranked opponent in 2025 — and now they confront their most challenging road atmosphere to date, led by a young quarterback who is still acclimating to the rigorous demands of SEC defenses. Let’s gear up for some #22 Missouri vs. #8 Oklahoma picks!

#22 Missouri vs. #8 Oklahoma Predictions for College Football Week 13, Saturday, 11/22

This presents a compelling juxtaposition: a veteran, playoff-oriented Oklahoma squad showcasing its strongest defense in years against a skilled Missouri team striving to solidify its offense with an unseasoned quarterback.

With OU needing to secure victories to remain in the CFP discussion and Missouri aiming to demonstrate its place among the elite in the SEC, Saturday's early kickoff promises to be one of the most captivating matchups of Week 13. Below, we provide our comprehensive #22 Missouri vs. #8 Oklahoma predictions, detailing why the spread is favorable for OU in this scenario.

 

 

 

#22 Missouri vs. #8 Oklahoma Spread Pick: Sooners -7.5 (-120 at DraftKings)

Oklahoma approaches Week 13 showcasing its most complete football performance of the season, and last week’s victory on the road against Alabama served as a declaration that this team possesses the composure, defensive strength, and offensive character necessary to secure a position in the top 12 and possibly infiltrate the playoff landscape.

They have now triumphed over four ranked opponents and stand as one of the few teams in the SEC that is gaining momentum as the season progresses.

Conversely, Missouri remains a challenging team to assess. They have demonstrated moments of exceptional play; however, their failure to convert drives against top-tier defenses — coupled with the developmental challenges faced by their young quarterback, who is filling in due to injury — has resulted in a lack of consistency.

Missouri holds a record of 0-3 against ranked teams this season, with two of those defeats occurring on their home turf. They now prepare to enter one of the most raucous environments in college football, confronting a defense that ranks among the top 10 nationally in points allowed.

The defense of OU has subtly served as the driving force behind its achievements. With a ranking of eighth in scoring defense and having restricted six opponents to 17 points or fewer, the Sooners have evolved into a formidable unit that secures victories through gap discipline, athletic prowess, and genuine closing speed across all three levels.

The recent 23–21 victory at Alabama exemplified this perfectly — they effectively suppressed the run game, compelled predictable passing situations, and, crucially, excelled in the red zone.

This is of significant importance against Missouri, which has surpassed 17 points only once in its last three SEC contests. The Tigers' offense heavily depends on RB Ahmad Hardy, who is undoubtedly explosive; however, OU's defensive front is well-prepared to contain a run-heavy strategy.

The passing game of Missouri has struggled to find its rhythm for several weeks, and although Hardy's impressive 300-yard performance last week garnered attention, the Tigers' failure to replicate such an outing against elite defenses raises genuine concerns. 

John Mateer may not consistently achieve impressive statistics each week, yet he operates effectively within the framework of the offensive strategy, safeguards the football, and reliably capitalizes on scoring opportunities through his mobility and precision in the intermediate passing game.

OU does not need 40 points to cover this spread. They probably won’t even need 35. If the Sooners reach the high 20s — a feat they have accomplished regularly — their defense should handle the remainder.

Few teams in the nation have as much at stake this week. Oklahoma must secure victories in its final two games to stay in contention for the playoffs, both of which are at home. In contrast, Missouri has already achieved its bowl-eligibility goal, and while they will undoubtedly compete, they are not facing the same level of urgency.

This presents a particularly challenging situation for Missouri: a young quarterback, a difficult road environment, a formidable defense on the opposing side, and an opposing team that is playing its best football at the most opportune moment. Our #22 Missouri vs. #8 Oklahoma predictions will lay the points with the Sooners.

 

 

 

How To Watch #22 Missouri vs. #8 Oklahoma College Football Week 13

  • Date: Saturday, November 22, 2025
  • Time: 12:00 p.m. ET
  • Location: Gaylord Family Oklahoma Memorial Stadium — Norman, OK
  • Network: ABC

#22 Missouri vs. #8 Oklahoma Odds, Spreads, Total & Betting Lines

We’ve just published our #22 Missouri vs. #8 Oklahoma predictions for the matchup. Now, let’s examine the most recent #22 Missouri vs. #8 Oklahoma odds for the game from DraftKings Sportsbook:

  • Money Line (ML): Tigers +250 | Sooners -310
  • Spread: Tigers +7.5 (-115) | Sooners -7.5 (-105)
  • Over/Under (O/U): 41.5 (O: -112 | U: -108)

 

 

 

#22 Missouri vs. #8 Oklahoma Injury Report & Latest News

Missouri Injury Report

  • D. Fowlkes (WR) – Questionable, Undisclosed
  • L. Kitchen (DL) – Probable, Undisclosed
  • B. Pribula (QB) – Doubtful, Ankle
  • S. Horn (QB) – Out, Leg
  • B. Craig (K) – Out, Undisclosed

Oklahoma Injury Report

  • J. Taylor (OG) – Out, Undisclosed
  • J. Sexton (OG) – Out, Undisclosed
  • J. Barnes (RB) – Questionable, Undisclosed
  • G. Williams (CB) – Questionable, Undisclosed
  • T. Everett (OG) – Out, Undisclosed

 

 

 

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