The 2025 College Football season rolls on with a full Friday slate of Week 14 games. Welcome to our CFB Best Bets as we break down CFB picks for this week’s action. Let’s focus on two matchups for our top CFB predictions. Plus, check out more college football bets below.  

Friday’s Week 14 college football slate lasts all day and all night. That means we have plenty of ways to go for our CFB picks. Note that all bets below are for one unit unless otherwise noted. Without further ado, let’s dive into our CFB Best Bets. 

 

 

 

CFB Picks, Predictions & Best Bets: Friday, 11/28

Let’s kick off Friday’s Week 14 CFB Best Bets with a Big Ten showdown between Iowa and Nebraska. Plus, San Diego State takes on New Mexico in the Mountain West. Be sure to check out more CFB picks below for other notable Friday Week 14 games, including Texas A&M vs. Texas and Georgia vs. Georgia Tech. That includes some intriguing college football player props as well. Good luck!  

Iowa vs. Nebraska Prediction: Friday, November 28th

Iowa has dominated this rivalry with Nebraska in recent years. The Hawkeyes are 9-1 straight up against the Cornhuskers over the past 10 meetings. On Friday, Iowa is the road favorite in a matchup of 7-4 teams. Let’s break it down.

On offense, Iowa’s run game can be a difference-maker against Nebraska’s poor rush defense. The Cornhuskers are allowing 5.1 yards per carry in conference play this season (117th in FBS) while giving up 179.3 rushing yards per game to Big Ten opponents. They also rank 125th nationally in defensive success rate vs. the run and 124th in EPA/Rush defensively. 

In Nebraska’s losses this year, the run defense has been a deciding factor. The ‘Huskers have allowed 226.3 rush yards per game in their 4 losses so far. That includes 231 yards on 5.9 yards per carry vs. Penn State just last week. 

Iowa has the top-tier rushing attack to take advantage of this matchup. The Hawkeyes are 16th in the FBS in rushing success rate and 21st in EPA/Rush, while averaging 174.6 rush yards per game (50th). Ground-and-pound is what they do with a workhorse back in Kamari Moulton (5.0 YPC) and dual-threat QB Mark Gronowski, who has 13 rushing TDs on the year. 

Meanwhile, Iowa brings in a strong defense. It’s allowing just 14.9 PPG this season (9th in FBS) while ranking 8th nationally in total yards allowed per game and 14th in defensive EPA. This elite defense can limit a Nebraska attack that’s been inconsistent. The ‘Huskers are 75th in EPA/Rush and 60th in EPA/Pass. They could have trouble stringing together drives against Iowa’s stout defense. 

Let’s back Iowa to win and cover on the road here. The Hawkeyes are 3-0-1 ATS on the road this year, including 2-0 ATS as road favorites. They’re also 3-1 ATS as a single-digit favorite this season. 

 

 

 

San Diego State vs. New Mexico Prediction: Friday, November 28th

This is a crucial game in the Mountain West Conference. The winner between San Diego State and New Mexico will host the conference championship next week. The loser could miss out on a title game appearance entirely. It’ll surely be a tight matchup, but one side presents some value. 

San Diego State has looked like the best team in the MWC all season. Head coach Sean Lewis completely flipped the program around in his first year on the job. The Aztecs have the opportunity to get to double-digit wins and host the league title game. That’s even more impressive when you consider they were 3-9 last season and 4-8 the year before. 

SDSU comes in with a 6-1 conference record. The only hiccup was an outlier blowout loss on the road at Hawaii. That’s understandable given the tough travel spot and the fact that Hawaii has proven to be a completely different team at home. Otherwise, for the Aztecs, their 6 conference wins have come by an average of 21.2 PPG, with each being double-digit margins. 

San Diego State’s defense is the clear-cut best unit on the field. Let’s back the Aztecs to get the victory by leaning on their elite-level defense that’s giving up only 11.6 PPG this season (2nd in FBS). They’re also 6th in the country in total yards allowed per game, 2nd in defensive EPA, and 6th in defensive success rate. 

The SDSU defense is dominant against both the run and pass as well. It’s a tough matchup all around for New Mexico. The Lobos prefer to lean on the run with inside zone read actions and dual-threat QB play. Yet, the Aztecs specialize in shutting down zone read concepts and should be well prepared. 

As their defense sets the tone for a low-scoring contest, the Aztecs should have just enough success on offense. Specifically, New Mexico’s pass defense has struggled this year. The Lobos rank 106th nationally in passing yards allowed per game and 98th in EPA/Pass defensively. SDSU QB Jayden Denegal can have one of his better performances of the year in this matchup. 

 

 

 

Best CFB Prop Bets & Other Picks for Friday, Week 14

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