The 2025 College Football season rolls on with a full Saturday slate of Week 2 games. Welcome to our CFB Best Bets as we break down CFB picks for this week’s action. Let’s focus on two matchups for our top CFB predictions. Plus, check out more college football bets below.  

Saturday’s Week 2 college football slate lasts all day and night long. That means we have plenty of ways to go for our CFB picks. Note that all bets below are for one unit unless otherwise noted. Without further ado, let’s dive into our CFB Best Bets. 

CFB Picks, Predictions & Best Bets: Saturday, 9/6

Let’s kick off Saturday’s Week 2 CFB Best Bets with a Top 25 matchup between No. 15 Michigan vs. No. 18 Oklahoma. It’s one of the best games of the weekend, so let’s find a betting angle. Plus, Tulsa visits New Mexico State for an interesting Saturday night battle. Be sure to also check out more CFB picks for Baylor vs. SMU, Kansas vs. Missouri, and other games below. Let’s get to it. 

 

 


 

Michigan vs. Oklahoma Prediction: Saturday, September 6th

The marquee matchup this week features No. 18 Oklahoma hosting No. 15 Michigan. Both programs have College Football Playoff aspirations, and this game offers a resume-boosting opportunity. Let’s break it down. 

Michigan and Oklahoma both earned easy wins in Week 1 against soft competition. The Sooners cruised to a 35-3 victory over Illinois State, while the Wolverines grabbed a 34-17 home win against New Mexico. The competition now ramps up considerably for both, which matters more for the offenses, as this one stays lower-scoring. 

QB Bryce Underwood showed some flashes in Week 1 for Michigan. The skill level and upside are there, but the true freshman now gets his first real test. The inexperience will bleed through against a stout Oklahoma defense in a hostile road environment. It’s a complete flip from facing New Mexico’s weak defense at home last week. 

The Wolverines also have multiple question marks along the offensive line and in the WR corps. The lack of proven pass-catching weapons for Underwood, outside of tight end Marlin Klein, will especially be an issue against tougher defenses. Oklahoma certainly falls in that category after ranking 19th and 29th last year in total yards and points allowed per game, respectively. 

Michigan knows it needs to lean on its defense to stay in this game. On that note, the Wolverines’ unit will face an Oklahoma offense with some concerns as well. Yes, QB John Mateer went off last week with 392 passing yards and 3 TDs. But it also came against Illinois State’s FCS-level defense. 

Meanwhile, Oklahoma’s inability to run the football in Week 1 was worrisome. The Sooners averaged just 3.2 yards per carry with their leading rusher having 44 yards. The OU offensive line was an issue at times last year, and the lack of success against an FCS defensive front is concerning. Plus, considering the matchup, only scoring 21 points heading into the fourth quarter isn’t a great look. 

Michigan’s defense, especially on the line, is miles better than what Illinois State showed. Wolverines defensive coordinator Wink Martindale has a proven track record of exploiting weaknesses in opposing offenses, and he can do that this week. Expect him to dial up more blitzes to test that shaky Oklahoma O-line and force Mateer to make plays under duress. 

Plus, if Oklahoma struggles on the ground again, it puts more pressure on Mateer to deliver in the passing game. He did it last week in a cupcake matchup. Michigan now presents a much tougher challenge. Let’s take the under as both defenses set the tone in this primetime showdown. 

 

 


 

Tulsa vs. New Mexico State Prediction: Saturday, September 6th

This game doesn’t have nearly the same pedigree as the one above, but there’s still a betting angle to exploit as Tulsa takes on New Mexico State. Let’s back the road favorites here as the Golden Hurricane have the clear edge offensively. 

Tulsa won comfortably in Week 1 with a 35-7 victory over Abilene Christian. It’s an encouraging start to the season for a program that went 3-9 a year ago. The offense displayed a balanced attack, led by the talented two-headed backfield of Baylor transfer Dominic Richardson and Miami (FL) transfer Ajay Allen. The RB duo combined for 209 rushing yards and 2 scores on 7.2 yards per carry in the opener. 

The Golden Hurricane's run game will be a major factor in this matchup. New Mexico State ranked 115th in the FBS in rush defense last year, allowing 195.3 yards per game. The Aggies’ defense allowed only 3 points in Week 1, but that was also against Bryant (an FCS team). The competition gets a lot tougher now. 

On the other side of the ball, New Mexico State’s offense likely fails to keep up. Last year, the Aggies looked lost offensively while struggling to replace playmaking QB Diego Pavia, who transferred to Vanderbilt. The result was a unit that ranked 115th nationally in points per game and 121st in total yards per game.

New Mexico State won’t be much better on offense this season. That showed in Week 1 as the Aggies only scored 9 points heading into the fourth quarter, which is pretty poor against an FCS defense. Logan Fife at quarterback doesn’t move the needle, and the offense still severely lacks skill players. 

Tulsa should win this game by at least a touchdown. The homefield advantage won’t matter much for a New Mexico State team that’s still figuring things out. Back the Golden Hurricane to cover the spread. 

 

 

 

Best CFB Prop Bets & Other Picks: Saturday, 9/6

 

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