The 2025 College Football season rolls on with a full Saturday slate of Week 14 games. Welcome to our CFB Best Bets as we break down CFB picks for this week’s action. Let’s focus on two matchups for our top CFB predictions. Plus, check out more college football bets below.  

Saturday’s Week 14 college football slate lasts all day and all night. That means we have plenty of ways to go for our CFB picks. Note that all bets below are for one unit unless otherwise noted. Without further ado, let’s dive into our CFB Best Bets. 

 

 

 

CFB Picks, Predictions & Best Bets: Week 14 Saturday, 11/29

Let’s kick off Saturday’s Week 14 CFB Best Bets with a Top 25 showdown in the SEC as Vanderbilt hosts Tennessee. Plus, Washington hosts Oregon in a marquee Big Ten matchup. Be sure to check out more CFB picks below for other notable Week 14 games, including Ohio State vs. Michigan and Alabama vs. Auburn. Good luck!  

Vanderbilt vs. Tennessee Prediction: Saturday, November 29th

This SEC matchup carries a ton of weight for the College Football Playoff. No. 14 Vanderbilt could essentially lock up a spot in the Playoff with a road victory this week, while a loss would surely end all hopes. Meanwhile, No. 19 Tennessee can rise up the rankings with a win, though it needs some help. 

The Vols are slight home favorites for this game, but Vandy is a live underdog. Instead of picking a side, let’s focus on the total. Both offenses should set the tone for a high-scoring shootout. The must-win situation for both squads should also force both offenses to get creative and generate explosive plays, while keeping things more uptempo.  

Vanderbilt’s offense is among the best in college football. The Commodores are averaging 38.9 PPG (11th in FBS), and they’ve scored 45 points in back-to-back games vs. Kentucky and Auburn coming into the weekend. The ‘Dores rank 1st nationally in EPA/Play and 2nd in offensive success rate, while boasting strong passing and running games. 

Even on the road in a tough environment, Vandy’s offense can put up points here. Tennessee is giving up 32.0 PPG to SEC opponents this year. In three ranked matchups so far, the Volunteers have allowed 44, 37, and 33 points to Georgia, Alabama, and Oklahoma, respectively. They also rank 124th in the FBS in defensive success rate and 122nd in total defensive EPA. 

The Vols have struggled against both the run and pass. It’s a great spot for Vanderbilt QB Diego Pavia to have yet another big performance. The Heisman contender is on a roll right now, throwing for 484, 377, and 365 yards over the past 3 games. He’s also accounted for 14 total TDs in this stretch. 

On the other side, Tennessee’s offense can certainly light up the scoreboard as well. The Vols are averaging 42.3 PPG this year (4th in FBS), including 40.8 PPG in their 6 home/neutral FBS matchups. They rank 4th nationally in total yards per game, 10th in offensive success rate, and 25th in total offensive EPA. 

Tennessee’s potent passing attack should especially have success in this matchup. Vanderbilt is giving up 282.6 passing yards per game in conference play (129th in FBS) while ranking 133rd nationally in defensive EPA vs. the pass. The Vols will be throwing a ton against this Commodores’ shaky secondary. Their offense boasts multiple talented pass-catchers and a QB in Joey Aguilar who’s taken advantage of favorable matchups. 

Let’s take the over and root for points on both sides. Vandy is 7-3 to the over vs. FBS competition this year, including 6-2 to the over in the last 8 games. Tennessee is 7-4 to the over this year, including 5-2 in home/neutral games.

 

 


 

Oregon vs. Washington Prediction: Saturday, November 29th

Oregon is coming off a convincing 42-27 win over USC last week. The victory makes the Ducks a near lock to make the College Football Playoff. However, a loss this weekend at Washington would make things interesting, depending on other results around the country. The Huskies could be live to pull the upset, but let’s just focus on the total. 

Both defenses in this game should set the tone for a low-scoring matchup. Oregon is allowing just 14.9 PPG this season (8th in FBS), including just 14.6 PPG allowed over the past 5 games. The Ducks rank 3rd nationally in total defense, 8th in defensive EPA/Play, and 13th in defensive success rate. 

Oregon’s defense is one of the best in the country and should limit the Washington attack. The Huskies have scored 49 and 48 points in back-to-back games, but those outputs came against bad Purdue and UCLA teams. When facing tougher defenses in the Big Ten, though, they’ve mustered 10 or fewer points against Ohio State, Michigan, and Wisconsin. 

Meanwhile, Washington brings in a solid defense of its own. The Huskies are allowing just 18.8 PPG this year (19th in FBS) and rank 18th nationally in total defense. They’re especially strong against the run, allowing 3.47 yards per carry (25th) and ranking 16th in the country in defensive EPA/Rush. 

That run defense will be a problem for Oregon. Its offense is at its best with a balanced approach while leaning enough on the ground game with Noah Whittington and Jordon Davison. If both backs are bottled up, then it puts more pressure on Dante Moore and the passing attack. Well, the Ducks are still dealing with multiple injuries in the receiving corps, and tight end Kenyon Sadiq is the only reliable playmaker right now. 

Oregon’s offense has also stalled at times when facing tougher defenses. The Ducks scored just 18 points vs. Iowa, 20 points vs. Indiana, and 21 points vs. Wisconsin. The offense likely won’t be able to generate many explosive plays on the road in this matchup, especially via the run. 

Let’s grab the under for this Big Ten showdown between former Pac-12 rivals. The under has cashed in 5 of the last 8 meetings between the teams, and another should be coming this weekend. 

 

 

 

Best CFB Prop Bets & Other Picks: Saturday, 11/29

 

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