The 2025 College Football season rolls on with a full Saturday slate of Week 13 games. Welcome to our CFB Best Bets as we break down CFB picks for this week’s action. Let’s focus on two matchups for our top CFB predictions. Plus, check out more college football bets below.  

Saturday’s Week 13 college football slate lasts all day and all night. That means we have plenty of ways to go for our CFB picks. Note that all bets below are for one unit unless otherwise noted. Without further ado, let’s dive into our CFB Best Bets. 

CFB Picks, Predictions & Best Bets: Week 12 Saturday, 11/22

Let’s kick off Saturday’s Week 13 CFB Best Bets with a Top 25 showdown in the SEC as No. 8 Oklahoma hosts No. 22 Missouri. Plus, North Texas faces Rice in an AAC matchup. Be sure to check out more CFB picks below for other notable Week 13 games, including USC vs. Oregon and BYU vs. Cincinnati. That includes some intriguing college football player props as well. Good luck!  

 

 

 

Missouri vs. Oklahoma Prediction: Saturday, November 22nd

This is one of the two matchups between Top 25 teams this weekend. The other, featuring Oregon and USC, will likely be on the higher-scoring side. This one won’t. Expect the defenses to set the tone for an SEC rock fight as Oklahoma takes on Missouri. 

Oklahoma’s defense is among the best in college football. The Sooners are allowing only 14.8 PPG this season (8th in FBS) while giving up just 278.4 total yards per contest (11th). They also rank 1st in the country in defensive success rate and 4th in defensive EPA. 

OU’s elite defense is strong against both the run and pass as well. The run-stopping, though, will be key in this week’s matchup. More on that in a second. First, some stats. The Sooners are 1st nationally in defensive success rate against the run and 2nd in defensive EPA vs. the rush. In turn, they’re allowing only 2.48 yards per carry (2nd in FBS). 

Missouri’s offense could be in trouble because it prefers to lean on the ground game. The Tigers rank 6th in the FBS in rushing yards per game and 9th in EPA/Rush. They boast a stud running back in Ahmad Hardy, who leads the country in rushing so far this year, and a solid change-of-pace in Jamal Roberts.

However, if that ground-and-pound can’t get going, then it might be a long day for the Mizzou offense. It’ll put more pressure on the passing attack, which is a bit murky. Starting QB Beau Pribula is questionable to play after suffering a dislocated ankle last month. If he plays, the dual-threat QB will surely be limited and not as effective running-wise. If he sits, then true freshman Matt Zollers gets another start. 

We’ve seen mixed results from Zollers. He played well in relief of Pribula against Vanderbilt, but that also came against a subpar secondary. The youngster then struggled mightily against Texas A&M with the following passing line: 7-of-22 for 77 yards. The offense was also able to lean on the run with Hardy and Roberts combining for 219 rush yards. In the next game, Zollers was just 8-for-15 passing against a shaky Mississippi State defense, and Mizzou also ran for 326 yards on 39 carries in the victory. 

That rushing success simply won’t be there against this Oklahoma defense. Mizzou will have to pass it more, and that’s something Zollers hasn’t shown he can do in a tough matchup in his first collegiate season. Again, Pribula could play, but his health is a big question mark. 

Meanwhile, Missouri can also count on its defense to keep the game low-scoring. The Tigers are 10th nationally in total yards allowed per game while giving up 19.9 PPG (25th in FBS). They also rank 6th in defensive success rate and 14th in EPA/Play defensively. 

That brings us to the OU offense, which has underwhelmed even with John Mateer back at quarterback lately. The Sooners mustered only 212 total yards of offense in last week’s win at Alabama. Overall, this season, the offense ranks 89th in the country in total yards per game, 100th in EPA/Play, and 86th in success rate. 

With a pair of dominant defenses here, let’s root for a low-scoring game all around. Take the under on the full game and the first half totals. Plus, take the under on Missouri’s team total. 

 

 


 

North Texas vs. Rice Prediction: Saturday, November 22nd

The American Athletic Conference is wide open with two weeks left in the regular season. The league currently has 4 teams with one loss in conference play, and each can realistically make the title game. The AAC champ then would have a good shot of making the College Football Playoff via an auto bid.   

North Texas is one of those teams, and it should have plenty of motivation to win big this weekend. Tulane was the lone AAC team to appear in the latest CFP rankings at No. 24. That means the Playoff committee views Tulane as the stronger team, in metrics and resume, than North Texas right now. 

So, North Texas will want to post yet another blowout victory to change the committee’s minds for next week’s rankings. On that note, the Mean Green are hammering opponents weekly lately. 

Since losing to South Florida, this North Texas squad has reeled off four straight convincing wins. The Mean Green just beat UAB by 29 points, having won the three previous games by the following margins: 14 points against Navy, 34 points against Charlotte, and 38 points against UTSA. 

North Texas’s offense is especially. It’s averaging an FBS-best 45.3 PPG while ranking 5th nationally in total yards per game. The Mean Green are also 3rd in the country in offensive EPA and 6th in offensive success rate. 

It’s hard to see Rice stopping this dominant offense. The Owls have failed to compete in some of their toughest games this year. They lost by 24 points to Memphis two games ago, failing to cover as 14-point home underdogs. They got crushed by UTSA, 61-13. They also suffered a 26-point home loss to Houston back in Week 2, failing to cover as 14-point dogs. 

Meanwhile, North Texas is 8-2 against the spread this season. They covered as an 18-point favorite last week and as a 25-point favorite vs. Charlotte three games ago. The Mean Green is also 4-1 ATS as double-digit favorites this year. 

It’s a big spread this week, but North Texas should be ready to post a big number offensively. Rice’s offense is nowhere near the level of the Mean Green right now, and that’ll show on the final scoreline. 

 

 

 

Best CFB Prop Bets & Other Picks: Saturday, 11/22

 

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