Two programs riding positive momentum will clash in Columbia this Saturday, as the No. 8 Alabama Crimson Tide take on the No. 14 Missouri Tigers in a crucial SEC matchup. After a rocky start against Florida State, Alabama has found its groove, while Missouri comes in undefeated and well-rested following a bye.

Our #8 Alabama vs. #14 Missouri picks below give insight into how we’ll be playing this one. Betting experts anticipate a closely contested game — Alabama is a slight 3-point favorite on the road — but the home team may offer better value considering its rest, efficiency, and the Crimson Tide’s biggest weakness…

#8 Alabama vs. #14 Missouri Predictions for College Football Week 7, Saturday, 10/11

Both teams boast strong defenses and top-10 scoring offenses, but the main question is whether Missouri’s impressive stats can withstand the challenge posed by Alabama’s experience. The Tigers have yet to face a ranked opponent this season, whereas the Tide have already secured victories against Georgia and Vanderbilt in consecutive weeks.

This seems to be one of those moments where the metrics and the market finally come together, at least according to our #8 Alabama vs. #14 Missouri predictions. Missouri is currently undefeated, averaging over 45 points per game, and has shown dominance on both offense and defense. However, the betting line indicates that Alabama — despite their recent achievements — is still being valued based on their reputation.

 

 

 

#8 Alabama vs. #14 Missouri Spread Pick: Tigers +3.5 (-110 at Rebet)

The Tigers’ defense has proven to be nothing less than elite. After five games, Missouri ranks second in the nation for total yards allowed (203.8 per game) and third for rushing yards allowed (62.4). Although the pass defense hasn’t faced many challenges, it still stands among the top 15 in yards allowed per game.

On the other hand, Alabama’s offense remains heavily reliant on passing and somewhat predictable. Quarterback Ty Simpson has been outstanding, averaging over 325 yards per game through the air, but the Crimson Tide’s running game continues to struggle.

In their games against Georgia and Vanderbilt, Alabama allowed over 220 rushing yards per game defensively while failing to find any rhythm on the ground offensively. This raises concerns as they head into Columbia, where Mizzou’s running back duo of Ahmad Hardy and Deion Burks has already combined for over 1,000 rushing yards and 12 touchdowns this season.

Hardy, in particular, has been a game-changer. The sophomore leads the SEC in yards per carry (7.1) and could be crucial in managing the pace of the game. If Missouri’s offensive line can mirror the success that Georgia’s front had against Alabama’s interior, the Tigers will not only cover the spread but could very well secure an outright victory.

Yes, Alabama has proven to be the more seasoned team — and their victories against ranked Georgia and Vanderbilt are certainly noteworthy — yet those matchups also revealed some vulnerabilities. The Tide has had difficulty defending the perimeter and has allowed several big plays in the air. 

Missouri quarterback Beau Pribula has quietly emerged as one of the most effective passers in the conference, boasting a 12-to-2 touchdown-to-interception ratio and a 72% completion rate. If Cook can maintain his composure against Alabama’s pressure, the Tigers’ well-rounded offense should be able to advance the ball consistently.

Another significant advantage for Missouri? The atmosphere. Memorial Stadium will be electric for its first top-15 home matchup in years. This is a program that has been preparing for this kind of moment — a chance to make a statement against the SEC’s most prominent brand. Furthermore, considering that Missouri is 7-2 against the spread in its last nine home games and 8-2 ATS overall in its last ten, there’s substantial value in supporting the home underdog.

Anticipate a low-scoring, hard-fought battle. Alabama’s defensive front will challenge Missouri’s offensive line from the start, and the Tigers’ secondary will need to contend with Alabama’s deep passing game. However, Missouri’s depth on the defensive line and its capacity to apply pressure without blitzing could lead to mistakes from Simpson in the later stages of the game.

If this matchup were on neutral ground, Alabama would likely win by a field goal. However, playing at home, coming off a bye, with a dynamic running game and a savvy defense, Missouri has every reason to keep the score close. And, as our #8 Alabama vs. #14 Missouri predictions have alluded to, perhaps even pull off the SEC’s next major upset.

 

 

 

How To Watch #8 Alabama vs. #14 Missouri College Football Week 7

  • Date: Saturday, October 11, 2025
  • Time: 12:00 p.m. ET
  • Location: Memorial Stadium, Columbia, Missouri
  • TV: ABC

#8 Alabama vs. #14 Missouri Odds, Spreads, Total & Betting Lines

As we examine the #8 Alabama vs. #14 Missouri predictions, we’re eager to present the latest #8 Alabama vs. #14 Missouri odds from Rebet for this exciting matchup:

  • Money Line (ML): Crimson Tide -155 | Tigers +130
  • Spread: Crimson Tide -3.5 (-110) | Tigers +3.5 (-110)
  • Over/Under (O/U): 51.5 (O: -110 | U: -110)

 

 

 

#8 Alabama vs. #14 Missouri Injury Report & Latest News

Alabama Injury Report

  • Q. Russaw (LB) – Questionable, Leg
  • J. Latham (LB) – Questionable, Neck
  • J. Beaman (DL) – Out, Lower Body

Missouri Injury Report

  • C. Green (OG) – Questionable, Undisclosed
  • L. Reichert (OG) – Questionable, Undisclosed
  • S. Horn (QB) – Out, Leg
  • B. Craig (K) – Out, Undisclosed

 

 

 

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Be sure to take full advantage of your first-deposit bonus, whether it relates to our #8 Alabama vs. #14 Missouri predictions, by clicking here to claim your offer. Just a friendly reminder: Rebet is legal in both Alabama and Missouri! Remember to use the Rebet promo code ALARM when you register.