Welcome back to another week of CFB DFS lineups and contests as we focus on the Friday night college football Week 4 slate. Before we get to Saturday's loaded CFB schedule of games, this Friday evening should be a fun one with some interesting matchups and CFB DFS picks. We have two power conference matchups with Wisconsin vs Purdue and NC State vs Virginia. Plus, the late-night Mountain West games add a fun wrinkle to our college football DFS lineups. Let's now dive into the top CFB DFS picks and plays for Friday night's college football Week 4 action. All the CFB Week 4 odds below are via DraftKings Sportsbook at the time of this writing. Let's now get into the top college football DFS picks for Friday's slate on September 22nd.
College Football Week 4 Friday Schedule
7 pm ET – Wisconsin (-6) at Purdue – 54 O/U
7:30 pm ET – NC State (-7.5) at Virginia – 48 O/U
10:30 pm ET – Boise State (-6.5) at San Diego State – 46.5 O/U
10:30 pm ET – Air Force (-6) at San Jose State – 45.5 O/U
College Football Week 4 Friday CFB DFS Picks
Top CFB DFS Quarterbacks
The QB position is rough on this small slate, but Brennan Armstrong is the clear top guy for cash lineups. His overall volume as both a passer and rusher gives him a high floor/ceiling combo. We saw him put up 27 DK with 96 rushing yards and 2 rush TDs in the season opener vs UConn. He could produce a similar or better output this week with NC State facing a poor UVA rush defense – allowing 191 rushing yards per game (120th in FBS) with 11 total rush TDs against over three games. Plus, revenge game anyone?
Tanner Mordecai honestly hasn’t been lighting up this year, but he’s a top QB play on this slate by default. Purdue’s defense is allowing 276.7 passing yards per game (115th in FBS) and got lit up by Fresno State’s Mikey Keene in Week 1. As for Mordecai, he’s coming off a 25 DK performance last week and has the upside to throw for 300+ yards with multiple scores in this matchup. He makes for a better GPP play than cash if you want to pivot away from Armstrong.
Although Taylen Green has underwhelmed so far this season, he’s very viable on this small slate as a cash or GPP Super-Flex option. The passing could be better, but Green’s running ability is what we like for DFS. He’s run for 103 yards and a TD through three games, but this is a guy who had 586 rushing yards and 10 rush TDs last year across 11 games, including multiple with 100+ yards. The San Jose State defense allowed 62 yards and a TD last week to Toledo dual-threat Dequan Finn and 2 rush TDs to Oregon St QB D.J. Uiagalelei. Overall, the rush defense has been bad, so the opportunity is there for Green running-wise.
Considering the lack of cheap QBs on this slate, don’t be surprised if Hudson Card is a chalky cash Super-Flex. The passing volume should be there with Purdue likely trailing Wisconsin and needing to throw more. That was the case last week as Card chucked it 46 times for 323 yards. The volume gives him a decent floor of 20 DK or so and that should be the case most weeks with Purdue’s defense looking shaky. Plus, it’s nice to see Card run in two TDs in back-to-back games.
The Virginia QB situation is the big wild card of the slate. Starter Tony Muskett has missed the last two games with a shoulder injury and is considered “day-to-day” this week. In his absence, Anthony Colandrea has started and he could again on Friday if Muskett can’t go. Colandrea put up 22 DK vs JMU two weeks ago and 12 DK last game vs Maryland. He’s cheap enough to be considered a GPP dart as your Super-Flex on this small slate.
Top CFB DFS Running Backs
After a quiet Week 2, Braleon Allen bounced back last game with 94 rushing yards, 2 TDs, and 24 DK on only 12 carries. While he is splitting work with Chez Mellusi, Allen is still one of the top DFS running backs at his best. We saw that in Week 1 when he went for 38 DK and 141 rush yards. Purdue just allowed 271 rush yards and 5 rush TDs to Syracuse last week. The Allen/Mellusi combo could match those numbers with both being top plays on this slate. You can consider Mellusi in GPPs, but Allen is the top cash RB to pay up for.
In Air Force’s triple-option offense, Owen Burk is the headliner this season with Brad Roberts gone. Burk has 75 and 110 rushing yards in the past two games with 18 and 15 carries, respectively. Unfortunately, he’s splitting touches with Emmanuel Michel, John Lee Eldridge, and QB Zac Larrier in this run-heavy attack. Still, the volume should be there for Burk to offer a solid cash floor with Air Force as a slight favorite. San Jose State’s rush defense with 229 yards allowed to Toledo last week and 197 to Oregon St in Week 1. Pencil in 100+ for Burk and possibly a TD or two.
This matchup vs Virginia is the best on the slate for NC State’s backfield. The UVA defense is allowing 191 rushing yards per game (120th in FBS) with opposing teams scoring 11 rush TDs already over three games. Dual-threat Brennan Armstrong should have success in this matchup, but one of these Wolfpack RBs can pop in GPPs. Michael Allen gets the slight nod because he’s cheaper and is a co-starter with Jordan Houston now. He’s also looked better with Allen averaging 7.4 ypc compared to Houston’s 3.8.
With George Holani out the last two games, Ashton Jeanty has taken full advantage of his lead back role. He had 35 DK, 200+ total yards, and a TD two weeks ago vs UCF and then 28 DK and three TDs last week. Jeanty also had 150+ yards, 2 TDs, and 34 DK in Week 1 vs Washington. He’s been a stud in the Boise State offense and now faces a suspect San Diego St defense that’s gotten torched on the ground by UCLA and Oregon St the past two weeks. If Holani is out again, Jeanty is a lock in all formats. Plus, his pass-catching role is an added bonus with 14 catches for 236 yards through three games already. If Holani returns, it puts Jeanty more as a high-upside GPP play with more risk.
The Air Force rush defense presents a tough matchup, but Kairee Robinson is a value RB to consider in GPPs. The San Jose State backfield looked like a split situation earlier this season, but Robinson got 16 touches for 61 yards and a TD last week compared to Conley’s six touches for 11 yards. Maybe this changes in Week 4, but Robinson is still the proven lead back from last year. He’ll likely go overlooked on this slate but can go for 15-20 DK if he finds the end zone and continues to get the majority of touches over Conley.
Virginia’s depth chart this week now lists Kobe Pace as a co-starter next to Mike Hollins. Former starter Perris Jones has now moved to third. This puts Pace into consideration at a dirt-cheap price for GPP or cash. He’s put up 21 and 14 DK in the past two games with three total TDs (two receiving). His role as a pass-catcher is also attractive as Virginia will likely be playing from behind vs NC State. Pace had four catches for 28 yards last week and a 75-yard TD reception the game prior. He's really the only sub-4k RB on the DK slate worth rostering.
Top CFB DFS Wide Receivers
Eric McAlister exploded for 143 receiving yards, 2 TDs, six catches, and 35 DK last week. It’s impossible to ignore that outburst as it looks like McAlister has quickly become a favorite target for QB Taylen Green. We have Stefan Cobbs still there, but McAlister leads the team in receptions and yards through three games. He’s taking advantage of a new starting role with Latrell Caples out for the season. The price increase isn’t ideal, but McAlister can still pop in GPP lineups and gets a boost without any top-tier WRs on this slate.
The Virginia receiving corps is basically a two-man unit right now. It’s Malik Washington and Malachi Fields getting the large share of targets and yards. Both can be considered on this small slate with UVA likely throwing more while trailing NC State. Washington could be more popular with back-to-back games of 100+ yards and 25+ DK. Fields, though, has 15 receptions for 144 yards over the past two games combined and offers a solid PPR floor at the cheaper price.
The Wisconsin passing attack is spreading the ball around to a bunch of different receivers. It’s unfortunate for DFS, but it gives us Chimere Dike as a value because of his average numbers thus far. Dike’s 161 yards lead the team through three games but he does only have eight catches thus far. Still, the guy was Wisconsin’s top WR last year and is one of Tanner Mordecai’s top targets when the Badgers go to the air.
Burks looked poised for a breakout season after posting 152 yards, 2 TDs, and 34 DK in Week 1. He’s come back down to Earth lately, but Burks is still the top receiver in Purdue’s offense and is filling the lost targets of Charlie Jones. In the mid-5k range on DK, he’s underpriced and should be a popular cash value. It’s a tough decision on FD, but we can count on Purdue throwing it a lot this week and Burks should be targeted plenty to return value.
If you read the Week 0 Playbook, then Nick Nash was a slam-dunk value in your lineups. He went off for 32 DK with six catches, 89 yards, and 3 TDs vs USC. The converted QB has been the clear top receiver in San Jose State’s offense and that will continue to be the case with Justin Lockhart now ruled out for the season. Nash had six catches for 80 yards last week and could post a similar stat line here. He’s too cheap on DK, considering his elevated FD price.
Yaseen exploded for 10 catches, 114 yards, and 24 DK last week in the loss to Syracuse. It’s even more impressive that he did it with Deion Burks and TJ Sheffield around. Yaseen had four catches and 45+ yards in both of the first two games, so it’s not like he hasn’t been involved. We’ll see if this trend continues, but we have to consider him differently after the latest stat line. Either way, Purdue has a pass-focused offense and will likely be trailing Wisconsin – so the targets should be there again for Yaseen to be a decent value in cash or GPP lineups.
There aren’t many San Diego State guys worth playing on this slate, but Mark Redman is a cheap option. The tight end leads the Aztecs in receptions (16), receiving yards (179), and TDs (2) so far. This offense lost its top two pass-catchers from last year and Redman has stepped into a larger role. He provides a decent PPR floor in DK cash lineups with 4+ catches in all three games and seeing plenty of targets. You could do a lot worse in this price range.
Unfortunately, Brennan Armstrong spreads the ball around a lot in the NC State passing attack. That makes it tough to pinpoint any one Wolfpack receiver for DFS, especially taking salaries into account. Kevin Concepcion is the team leader in receptions and yards through three games, but he’s also priced too high this week. Keyon Lesane has underwhelmed thus far and is also overpriced. You can easily play Armstrong on his own in lineups and don’t need to pair him with a WR. One GPP dart from NC St, though, is Bradley Rozner. His two receiving TDs lead the team and he’s much cheaper.
As mentioned above, Wisconsin’s offense is using multiple receivers right now. On the one hand, it’s tough to pinpoint any for DFS. However, it gives us a few values who can pop for a few catches, a TD, or double-digit points at cheap prices. Skyler Bell is one of those and he’s very cheap at sub-4k on DK. Bell has five catches for 40+ yards in back-to-back games coming into this week. You can also look at Will Pauling or Bryson Green as values, but Bell has better recent production.