The LSU Tigers are heading to Tuscaloosa to face the fourth-ranked Alabama Crimson Tide in a primetime SEC clash that has the potential to influence the playoff landscape. This long-standing rivalry has produced numerous thrilling conclusions, and although Alabama is favored by double digits, LSU's recent offensive momentum might make the contest more competitive than the bookmakers anticipate.

The game is scheduled to kick off on Saturday, November 8, at 7:30 p.m. ET at Bryant-Denny Stadium, with national coverage on ABC. Alabama aims to maintain its perfect record in conference play, while LSU seeks to disrupt their plans following a challenging period that included the dismissal of Brian Kelly. This big matchup brings about our expert LSU vs. #4 Alabama picks!

LSU vs. #4 Alabama Predictions for College Football Week 11, Saturday, 11/8

Alabama's quest for the playoff remains strong, yet this LSU squad is not one to back down. Anticipate an intense, high-scoring clash illuminated by the lights at Bryant-Denny. Both defenses have faced challenges against top-tier offenses, and both quarterbacks possess the skill to light up the scoreboard.

Although the spread seems accurate, the Over 49.5 bet appears to be the wiser choice for our LSU vs. #4 Alabama predictions. Alabama is likely to carry the offensive load, but LSU's ability to make big plays guarantees an abundance of excitement.

 

 

 

LSU vs. #4 Alabama Best Bet: Over 49.5 (-110 at Rebet)

The offensive prowess of the Crimson Tide is indisputable. Junior quarterback Ty Simpson has developed into one of the most effective passers in the country, amassing 2,184 yards, 20 touchdowns, and only one interception over eight games. He’s distributing the ball effectively to a talented receiving group led by Germie Bernard (526 yards, six TDs), with the Tide averaging 291.6 passing yards per game.

Alabama is ranked in the Top 10 nationally for EPA per dropback and passing success rate, highlighting Simpson’s control over the offense. They’ve scored a minimum of 27 points in four consecutive games, including 37 against Tennessee and 27 while playing away at Missouri.

Even when the running game has faced challenges, the passing game has ensured that defenses remain alert. Anticipate Alabama to capitalize on this strength once more against an LSU defense that has shown vulnerabilities against top-tier offenses.

Despite a challenging season, the Tigers are beginning to achieve offensive consistency with Garrett Nussmeier, who has accumulated 1,806 yards and 12 touchdowns. In their defeat against Texas A&M, LSU actually held a lead of 18–14 at halftime before conceding 35 points in the second half.

Alabama’s defense has shown vulnerabilities against explosive passing teams, permitting 333 yards to South Carolina and nearly 350 to Missouri in recent weeks. If Nussmeier can maintain his composure under pressure, LSU should generate more than enough offense to push this total Over.

These teams have faced off in some low-scoring battles in the past, but this iteration of the rivalry showcases two modernized offenses and defenses that can be taken advantage of. Alabama averages 34.4 points per game, ranking eighth in the SEC. The Over has been successful in four of Alabama’s last eight games, and in six of LSU’s last ten when they’re listed as double-digit underdogs.

When you combine Alabama’s deep passing game with LSU’s developing rhythm under Nussmeier and an aggressive interim coaching staff eager to make an impact, this matchup has the potential to evolve into a shootout under the lights in Tuscaloosa. At least, that’s how our LSU vs. #4 Alabama predictions see it.

 

 

 

How To Watch LSU vs. #4 Alabama College Football Week 11

  • Date: Saturday, November 8, 2025
  • Kickoff Time: 7:30 p.m. ET
  • Location: Bryant-Denny Stadium, Tuscaloosa, AL
  • TV Broadcast: ABC

LSU vs. #4 Alabama Odds, Spreads, Total & Betting Lines

We just layed out our LSU vs. #4 Alabama predictions for the matchup. Now, we present the most current LSU vs. #4 Alabama odds for the game from Rebet:

  • Money Line (ML): Tigers +312 | Crimson Tide -355
  • Spread: Tigers +10.5 (-118) | Crimson Tide -10.5 (+112)
  • Over/Under (O/U): 49.5 (O: -110 | U: -103)

 

 

 

LSU vs. #4 Alabama Injury Report & Latest News

LSU Injury Report

  • W. Weeks (LB) – Questionable, Ankle
  • G. Reliford (DL) – Questionable, Undisclosed
  • T. Adams (OG) – Questionable, Undisclosed
  • J. Lindsey (RB) – Out, Suspension

Alabama Injury Report

  • L. Brooks (WR) – Questionable, Undisclosed
  • D. Lewis Jr. (TE) – Questionable, Undisclosed
  • C. Jones (LB) – Questionable, Undisclosed
  • Q. Russaw (LB) – Questionable, Leg
  • J. Latham (LB) – Questionable, Neck
  • G. VanDeMark (OG) – Questionable, Undisclosed
  • J. Beaman (DL) – Out, Lower Body

 

 

 

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