With Carlos Hyde not playing, Mike Davis was presumed to be the starting RB for San Francisco. He is a decent streaming option as he's already managed to find the end zone. Depending on how long Hyde is out, Davis could be a serviceable flex option.
The 2005 2nd overall draft pick has been battling a finger injury during the preseason that has forced him to miss a few games, but he will be ready in time for Charlotte's first game on the road in Milwaukee.
Powell will take over for Goodwin as the Bills deep threat will head back to the locker room with a unknown injury.
Williams will take over as Ajayi will be out with cramping. His return status is unknown.
Former Boston Celtic Jared Sullinger will have to miss some time with a foot injury. Injuries haven't allowed him to progress in his young career, but while he has been on the court he has shown that he can be productive.
Marks will replace Jackson as he will not be able to return to the game after being ejected.
Johnson will take over at CB while Colvin gets his toe checked out. The Jags are currently trailing the Raiders.