Alex Cobb gave up one run on three hits and two walks with 11 strikeouts over 6.1 innings against the Astros on Friday.
Now there's the Cobb fantasy owners have been waiting for as the 26-year-old right-hander notched double-digit strikeouts for the first time this season and ended a brutal three-game losing streak in which he allowed 16 runs over just 15.1 innings. Perhaps he was still shaking off some disabled list rust there during that stretch, but fantasy owners are going to need him to press forward and use this game as the necessary springboard. He's got a home start against the Orioles to prove this was no fluke. ANALYST: Howard Bender
RB Carlos Hyde (foot) did not practice on Thursday.
Shaun Draughn will likely get his third straight start in the place of Carlos Hyde this week who didn't practice Thursday. Hyde has not done much at practice since he broke his foot and I'm not sure we will see much of him going forward. No need to risk anything with the 49ers not making any sort of playoff noise. Analysis: James Grande
Eric Weddle (groin) is not practicing on Thursday.
The Chargers have been disappointing this season but Eric Weddle continues to play great for the Chargers defense. Unfortunately, Weddle missed Thursday's practice due to a groin injury. Weddle is the Chargers leading tackler and the secondary would miss him dearly if he can't play in Week 12. Analysis: James Grande